The BMP Antagonist Follistatin-Like 1 Is Required for Skeletal and Lung Organogenesis

Follistatin-like 1 (Fstl1) is a secreted protein of the BMP inhibitor class. During development, expression of Fstl1 is already found in cleavage stage embryos and becomes gradually restricted to mesenchymal elements of most organs during subsequent development. Knock down experiments in chicken and zebrafish demonstrated a role as a BMP antagonist in early development. To investigate the role of Fstl1 during mouse development, a conditional Fstl1 KO allele as well as a Fstl1-GFP reporter mouse were created. KO mice die at birth from respiratory distress and show multiple defects in lung development. Also, skeletal development is affected. Endochondral bone development, limb patterning as well as patterning of the axial skeleton are perturbed in the absence of Fstl1. Taken together, these observations show that Fstl1 is a crucial regulator in BMP signalling during mouse development

Blueprint for a High-Performance Fluxonium Quantum Processor

Transforming stand-alone qubits into a functional, general-purpose quantum processing unit requires an architecture where many-body quantum entanglement can be generated and controlled in a coherent, modular, and measurable fashion. Electronic circuits promise a well-developed pathway for large-scale integration once a mature library of quantum-compatible elements have been developed. In the domain of superconducting circuits, fluxonium has recently emerged as a promising qubit due to its high-coherence and large anharmonicity, yet its scalability has not been systematically explored. In this work, we present a blueprint for a high-performance fluxonium-based quantum processor that addresses the challenges of frequency crowding, and both quantum and classical crosstalk. The main ingredients of this architecture include high-anharmonicity circuits, multipath couplers to entangle qubits where spurious longitudinal coupling can be nulled, circuit designs that are compatible with multiplexed microwave circuitry, and strongly coupled readout channels that do not require complex, frequency-sculpted elements to maintain coherence. In addition, we explore robust and resource-efficient protocols for quantum logical operations, then perform numerical simulations to validate the expected performance of this proposed processor with respect to gate fidelity, fabrication yield, and logical error suppression. Lastly, we discuss practical considerations to implement the architecture and achieve the anticipated performance

Bone-Breaking Bite Force of Basilosaurus isis (Mammalia, Cetacea) from the Late Eocene of Egypt Estimated by Finite Element Analysis

Bite marks suggest that the late Eocence archaeocete whale Basilosaurus isis (Birket Qarun Formation, Egypt) fed upon juveniles of the contemporary basilosaurid Dorudon atrox. Finite element analysis (FEA) of a nearly complete adult cranium of B. isis enables estimates of its bite force and tests the animal’s capabilities for crushing bone. Two loadcases reflect different biting scenarios: 1) an intitial closing phase, with all adductors active and a full condylar reaction force; and 2) a shearing phase, with the posterior temporalis active and minimized condylar force. The latter is considered probable when the jaws were nearly closed because the preserved jaws do not articulate as the molariform teeth come into occulusion. Reaction forces with all muscles active indicate that B. isis maintained relatively greater bite force anteriorly than seen in large crocodilians, and exerted a maximum bite force of at least 16,400 N at its upper P3. Under the shearing scenario with minimized condylar forces, tooth reaction forces could exceed 20,000 N despite lower magnitudes of muscle force. These bite forces at the teeth are consistent with bone indentations on Dorudon crania, reatract-and-shear hypotheses of Basilosaurus bite function, and seizure of prey by anterior teeth as proposed for other archaeocetes. The whale’s bite forces match those estimated for pliosaurus when skull lengths are equalized, suggesting similar tradeoffs of bite function and hydrodynamics. Reaction forces in B. isis were lower than maxima estimated for large crocodylians and carnivorous dinosaurs. However, comparison of force estimates from FEA and regression data indicate that B. isis exerted the largest bite forces yet estimated for any mammal, and greater force than expected from its skull width. Cephalic feeding biomechanics of Basilosaurus isis are thus consistent with habitual predation