44 research outputs found
Camparison of the Hanbury Brown-Twiss effect for bosons and fermions
Fifty years ago, Hanbury Brown and Twiss (HBT) discovered photon bunching in
light emitted by a chaotic source, highlighting the importance of two-photon
correlations and stimulating the development of modern quantum optics . The
quantum interpretation of bunching relies upon the constructive interference
between amplitudes involving two indistinguishable photons, and its additive
character is intimately linked to the Bose nature of photons. Advances in atom
cooling and detection have led to the observation and full characterisation of
the atomic analogue of the HBT effect with bosonic atoms. By contrast, fermions
should reveal an antibunching effect, i.e., a tendency to avoid each other.
Antibunching of fermions is associated with destructive two-particle
interference and is related to the Pauli principle forbidding more than one
identical fermion to occupy the same quantum state. Here we report an
experimental comparison of the fermion and the boson HBT effects realised in
the same apparatus with two different isotopes of helium, 3He (a fermion) and
4He (a boson). Ordinary attractive or repulsive interactions between atoms are
negligible, and the contrasting bunching and antibunching behaviours can be
fully attributed to the different quantum statistics. Our result shows how
atom-atom correlation measurements can be used not only for revealing details
in the spatial density, or momentum correlations in an atomic ensemble, but
also to directly observe phase effects linked to the quantum statistics in a
many body system. It may thus find applications to study more exotic situations
>.Comment: Nature 445, 402 (2007). V2 includes the supplementary informatio
JAK2V617F-homozigosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant clone
The granite‑hosted Variscan gold deposit from Santo António mine in the Iberian Massif (Penedono, NW Portugal): constraints from mineral chemistry, fuid inclusions, sulfur and noble gases isotopes
The study area is located in the Central Iberian Zone, a major tectonic unit of the Iberian Massif (Variscan belt). In this region the basement is composed of Cambrian-Ordovician sedimentary and minor volcanic rocks that underwent deformation and metamorphism during the Carboniferous. These metamorphic rocks host ca. 331–308 Ma granitic plutons emplaced during the D2 extensional and D3–D4 contractional deformation phases. The gold-bearing quartz veins from the Santo António mine (Penedono region) occur in granite formed at 310.1 ± 1.1 Ma and post-dated the peak of metamorphism. Gold–silver alloy is included in quartz, but mainly occurs in spaces between grains or micro-fractures within arsenopyrite of all three generations and less in pyrite. Late sulphides and sulphosalts were deposited along fractures mainly in arsenopyrite, and locally surrounding the gold–silver alloy grains. Ferberite, scheelite and stolzite replace arsenopyrite. The abundant aqueous carbonic fluids and the occurrence of a low-salinity fluid and their minimum possible entrapment temperature of 360–380 °C suggest that this gold-forming event began during the waning stages of the Variscan orogeny. The mean δ34S values of arsenopyrite and pyrite are − 4.7‰ and − 3.8‰, respectively. He–Ar–Ne isotopic data suggest a crustal origin. The ascent of the granite magma has provided the heat for remobilization of gold, other metals and metalloids from the metamorphic rocks. This gold-arsenopyrite deposit has thus similar characteristics as other selected gold-arsenopyrite deposits from the Iberian Massif, but it contains tungstates.El área de estudio está ubicada en la Zona Centroibérica, una importante unidad tectónica del Macizo Ibérico (cinturón
varisco). En esta región el basamento está compuesto por rocas sedimentarias y volcánicas del Cámbrico-OrdovÃcico tectonizadas y metamorfzadas durante el CarbonÃfero. Estas rocas metamórfcas sirven como caja de los plutones granÃticos datados
en torno a 331–308 Ma y que fueron emplazados durante la fase de deformación extensional D2 y las fases de deformación
contraccional D3 y D4. Las venas de cuarzo ricas en oro de la mina de Santo António (región de Penedono) que aparecen en
un granito datado a los 310.1 ± 1.1 Ma son posteriores al pico metamórfco regional. La aleación de oro y plata se incluye
en el cuarzo, pero se produce principalmente en los espacios entre granos o micro-fracturas dentro de arsenopirita de las
tres generaciones y menos en pirita. Los sulfuros y sulfuros tardÃos se depositaron a lo largo de las fracturas principalmente
en arsenopirita, y alrededor de los granos de aleación de oro y plata. Ferberita, scheelita y la estolzita sustituyen a la arsenopirita. Los abundantes lÃquidos acuosos carbónicos y la presencia de un fuido de baja salinidad y su posible temperatura
de atrapamiento mÃnima en torno de 360-380 ºC sugieren que este evento de formación de oro comenzó durante las etapas
fnales de la orogenia varisca. Los valores medios de S de arsenopirita y pirita son − 4.7 ‰ y − 3.8 ‰, respectivamente. Los datos isotópicos de He–Ar–Ne sugieren que en el origen de los fuidos mineralizados participa la corteza continental.
El ascenso del magma granÃtico ha provisto el calor para la movilización del oro, otros metales y metaloides desde las rocas
metamórfcas. Este depósito de oroarsenopirita tiene asà caracterÃsticas similares a otros yaciamientos con arsenopirita y oro
del Macizo Ibérico, pero sin embargo contienen tungstates.This research was financially supported by Fundação para a Ciência e Tecnologia through the projects GOLDGranites, Orogenesis, Long-term strain/stress and Deposition of ore metals—PTDC/GEO-GEO/2446/2012: COMPETE: FCOMP-01-0124-FEDER-029192 and UID/GEO/04035/2013
In vitro and in vivo evaluation of cord blood hematopoietic stem and progenitor cells amplified with glycosaminoglycan mimetic
Application of the API YeastIdent system in determining the enzymatic profiles ofNocardia asteroides isolates
Reproducible obtaining of human myeloma cell lines as a model for tumor stem cell study in human multiple myeloma
Screening paediatric rectal forms of azithromycin as an alternative to oral or injectable treatment.
The aim of this study was to identify a candidate formulation for further development of a home or near-home administrable paediatric rectal form of a broad-spectrum antibiotic - specially intended for (emergency) use in tropical rural settings, in particular for children who cannot take medications orally and far from health facilities where injectable treatments can be given. Azithromycin, a broad-spectrum macrolide used orally or intravenously for the treatment of respiratory tract, skin and soft tissue infections, was selected because of its pharmacokinetic and therapeutic properties. Azithromycin in vitro solubility and stability in physiologically relevant conditions were studied. Various pharmaceutical forms, i.e. rectal suspension, two different rectal gels, polyethylene glycol (PEG) suppository and hard gelatin capsule (HGC) were assessed for in vitro dissolution and in vivo bioavailability in the rabbit. Azithromycin PEG suppository appears to be a promising candidate