Magnetostriction measurement by using dual heterodyne laser interferometers

Electrical machines and transformers have a core built out of laminations of ferromagnetic materials. A portion of the vibrations and noise of these devices is due to magnetic forces and magnetostriction arising from the magnetic core. Magnetic forces are well known, and analytical methods are extensively used to calculate them. Magnetostriction can be defined as the deformation of the ferromagnetic material in the presence of a magnetic field. Unlike magnetic forces, magnetostriction shows a rather complex behavior. It varies for every material, and it depends on the applied magnetic field and external pressure. Therefore, magnetostrictive behavior of every material needs to be determined experimentally by means of strain measurements. Strain gauge measurement techniques have been used before at the Electrical Energy Laboratory (EELAB), Ghent University, Ghent, Belgium. In this paper, a new measurement method using dual heterodyne laser interferometers is proposed to overcome the drawbacks of the old method. The proposed measurement setup and the working principles are explained. The possibility to apply both techniques on one and the same sample can also reveal some interesting results about the quality of both techniques

Deformation of avian middle ear structures under static pressure loads, and potential regulation mechanisms

Static pressure changes can alter the configuration and mechanical behavior of the chain of ossicles, which may affect the acoustic transfer function. In mammals, the Eustachian tube plays an important role in restoring ambient middle ear pressure, hence restoring the acoustic transfer function and excluding barotrauma of the middle and inner ear. Ambient pressure fluctuations can be potentially extreme in birds and due to the simple structure of the avian middle ear (one ossicle, one muscle), regulation of the middle ear pressure via reflexive opening of the pharyngotympanic tube appears all the more important. In this study the deformations of the chicken (Gallus gallus domesticus) middle ear structures, as a result of middle ear pressure alterations, are quantified, using micro-CT scanning. It was experimentally tested whether reflexive opening of the pharyngotympanic tube to restore ambient middle ear pressure is present in chicken and mallard (Anas platyrhynchos) and whether this mechanism depends on sensing middle ear pressure indirectly via deformations of the middle ear components or sensing the middle ear pressure directly. A translation of the columella footplate was observed when middle ear pressure was kept at 1 kPa and -1 kPa relative to ambient pressure. Deformation of the tympanic membrane was larger than the columella footplate translation. Bending and deformation of the extracolumella was observed. Opening of the pharyngotympanic tube occurred at random pressure for both chicken and mallard when middle ear pressure was raised and lowered by 1.5 kPa relative to ambient pressure. We also did not find a difference in middle ear venting rate when middle ear pressure was held constant at 0.5, 1, 1.5, -0.5, -1 and -1.5 kPa for chickens and at 1, 2, 4, -1, -2 and -4 kPa for mallards. As a result, no statement can be made about pressure within the avian middle ear being measured directly or indirectly. Our experiments do not support the presence of a short-loop reflexive control of pressure equilibration via the pharyngotympanic tube. However, it is still possible that triggering this loop requires additional sensorial input (e.g. visual, vestibular) or that it occurs voluntarily (being controlled at a higher brain level)

Magnetostriction and the advantages of using noncontact measurements

Magnetic noise in electrical machines and transformers are a large portion of the total noise of the device. Part of this magnetic noise is caused by the deformation of the ferromagnetic laminations due to the magnetic field. This effect is called magnetostriction, and it strongly depends on the applied magnetic field, the material properties and external pressure to the material. A strain gauge measurement setup has been applied before to measure the magnetostrictive behaviour of ferromagnetic materials. The results obtained by this setup suffered from some limitations such as the need to filter high-frequency harmonics. Also the measurement results for excitation below 0.8T were not easily distinguished from the present noise. Therefore, a new setup using heterodyne laser interferometers has been built. With this new setup, on the contrary to the strain gauge setup, the sample preparation is simple. This new setup and the gradual improvements toward the optimal performance of the setup are presented in this paper

Eliminating transplant waiting time inequities – With an application to kidney allocation in the USA

Inequities in waiting times for deceased donor organ transplantation have received considerable attention in the last three decades and have motivated allocation policy reforms. This holds particularly true for kidney transplantation in the United States, where more than 90,000 patients are wait listed and average waiting times vary considerably among patients from different blood types and ethnic groups. This research presents a novel approach to formally model, analyze, and optimize equity of transplant waiting times and probabilities using queuing models, network flows, and Rawls’ Theory of Justice. The presented formal models address inequities resulting from blood type incompatibilities, which are interrelated to ethnic differences in patient and donor rates. Moreover, we present results of an application to the deceased donor kidney wait lists in the United States. The findings indicate that the allocation policies currently practiced red can virtually resolve blood type related inequities in average waiting time and transplant probability.</p

Measurement of magnetostriction using dual laser heterodyne interferometers : experimental challenges and preliminary results

Vibrations and noise of electrical machines and transformers may be caused by Lorentz forces and/or by magnetostriction. Here we only focus on the vibrations and noise due to magnetostriction. Electrical machines and transformers have magnetic cores of ferromagnetic material. Magnetostriction can be seen as a reaction of the ferromagnetic material to the presence of a magnetic field in the material and it leads to unwanted noise. The magnetostriction varies from material to material and is dependent on the magnetic field (or the magnetic induction) and on external stresses applied to the material. For every different material, the magnetostriction properties have to be obtained experimentally, usually by means of magnetostriction strain measurements. In the past a measurement set-up using strain gauges was developed at the Electrical Energy Laboratory (EELAB). In this paper a new magnetostriction measurement set-up using a dual laser heterodyne interferometer is proposed which avoids the drawbacks of the strain gauge set-up. The preliminary measurements already show some promising results. The experimental challenges and future work are explained at the end

Fluoroquinolone resistance during 2000–2005 : An observational study

<p>Abstract</p> <p>Background</p> <p>Moxifloxacin is a respiratory fluoroquinolone with a community acquired pneumonia indication. Unlike other fluoroquinolones used in our healthcare system, moxifloxacin's urinary excretion is low and thus we hypothesized that increased use of moxifloxacin is associated with an increase in fluoroquinolone resistance amongst gram negative uropathogens.</p> <p>Methods</p> <p>All antibiograms for Gram negative bacteria were obtained for 2000 to 2005. The defined daily dose (DDD) for each fluoroquinolone was computed according to World Health Organization criteria. To account for fluctuation in patient volume, DDD/1000 bed days was computed for each year of study. Association between DDD/1000 bed days for each fluoroquinolone and the susceptibility of Gram negative bacteria to ciprofloxacin was assessed using Pearson's Correlation Coefficient, r.</p> <p>Results</p> <p>During the study period, there were 48,261 antibiograms, 347,931 DDD of fluoroquinolones, and 1,943,338 bed days. Use of fluoroquinolones among inpatients decreased from 237.2 DDD/1000 bed days in 2000 to 115.2 DDD/1000 bed days in 2005. With the exception of <it>Enterobacter aerogenes</it>, moxifloxacin use was negatively correlated with sensitivity among all 13 Gram negative species evaluated (r = -0.07 to -0.97). When the sensitivities of all Gram negative organisms were aggregated, all fluoroquinolones except moxifloxacin were associated with increased sensitivity (r = 0.486 to 1.000) while moxifloxacin was associated with decreased sensitivity (r = -0.464).</p> <p>Conclusion</p> <p>Moxifloxacin, while indicated for empiric treatment of community acquired pneumonia, may have important negative influence on local antibiotic sensitivities amongst Gram negative organisms. This effect was not shared by other commonly used members of the fluoroquinolone class.</p

Reliability of Synaptic Transmission at the Synapses of Held In Vivo under Acoustic Stimulation

BACKGROUND:The giant synapses of Held play an important role in high-fidelity auditory processing and provide a model system for synaptic transmission at central synapses. Whether transmission of action potentials can fail at these synapses has been investigated in recent studies. At the endbulbs of Held in the anteroventral cochlear nucleus (AVCN) a consistent picture emerged, whereas at the calyx of Held in the medial nucleus of the trapezoid body (MNTB) results on the reliability of transmission remain inconsistent. In vivo this discrepancy could be due to the difficulty in identifying failures of transmission. METHODS/FINDINGS:We introduce a novel method for detecting unreliable transmission in vivo. Based on the temporal relationship between a cells' waveform and other potentials in the recordings, a statistical test is developed that provides a balanced decision between the presence and the absence of failures. Its performance is quantified using simulated voltage recordings and found to exhibit a high level of accuracy. The method was applied to extracellular recordings from the synapses of Held in vivo. At the calyces of Held failures of transmission were found only rarely. By contrast, at the endbulbs of Held in the AVCN failures were found under spontaneous, excited, and suppressed conditions. In accordance with previous studies, failures occurred most abundantly in the suppressed condition, suggesting a role for inhibition. CONCLUSIONS/SIGNIFICANCE:Under the investigated activity conditions/anesthesia, transmission seems to remain largely unimpeded in the MNTB, whereas in the AVCN the occurrence of failures is related to inhibition and could be the basis/result of computational mechanisms for temporal processing. More generally, our approach provides a formal tool for studying the reliability of transmission with high statistical accuracy under typical in vivo recording conditions

Looking into the cradle of the grave : J22564–5910, a potential young post-merger hot subdwarf

Context. We present the discovery of J22564–5910, a new type of hot subdwarf (sdB) which shows evidence of gas present in the system and it has shallow, multi-peaked hydrogen and helium lines which vary in shape over time. All observational evidence points towards J22564–5910 being observed very shortly after the merger phase that formed it. Aims. Using high-resolution, high signal-to-noise spectroscopy, combined with multi-band photometry, Gaia astrometry, and TESS light curves, we aim to interpret these unusual spectral features. Methods. The photometry, spectra, and light curves were all analysed, and their results were combined in order to support our interpretation of the observations: the likely presence of a magnetic field combined with gas features around the sdB. Based on the triple-peaked H lines, the magnetic field strength was estimated and, by using the SHELLSPEC code, qualitative models of gas configurations were fitted to the observations. Results. All observations can either be explained by a magnetic field of ∼650 kG, which enables the formation of a centrifugal magnetosphere, or a non-magnetic hot subdwarf surrounded by a circumstellar gas disc or torus. Both scenarios are not mutually exclusive and both can be explained by a recent merger. Conclusions. J22564–5910 is the first object of its kind. It is a rapidly spinning sdB with gas still present in the system. It is the first post-merger star observed this early after the merger event, and as such it is very valuable system to test merger theories. If the magnetic field can be confirmed, it is not only the first magnetic sdB, but it hosts the strongest magnetic field ever found in a pre-white dwarf object. Thus, it could represent the long sought-after immediate ancestor of strongly magnetic white dwarfs

Neural mechanisms of interstimulus interval-dependent responses in the primary auditory cortex of awake cats

<p>Abstract</p> <p>Background</p> <p>Primary auditory cortex (AI) neurons show qualitatively distinct response features to successive acoustic signals depending on the inter-stimulus intervals (ISI). Such ISI-dependent AI responses are believed to underlie, at least partially, categorical perception of click trains (elemental vs. fused quality) and stop consonant-vowel syllables (eg.,/da/-/ta/continuum).</p> <p>Methods</p> <p>Single unit recordings were conducted on 116 AI neurons in awake cats. Rectangular clicks were presented either alone (single click paradigm) or in a train fashion with variable ISI (2–480 ms) (click-train paradigm). Response features of AI neurons were quantified as a function of ISI: one measure was related to the degree of stimulus locking (temporal modulation transfer function [tMTF]) and another measure was based on firing rate (rate modulation transfer function [rMTF]). An additional modeling study was performed to gain insight into neurophysiological bases of the observed responses.</p> <p>Results</p> <p>In the click-train paradigm, the majority of the AI neurons ("synchronization type"; <it>n </it>= 72) showed stimulus-locking responses at long ISIs. The shorter cutoff ISI for stimulus-locking responses was on average ~30 ms and was level tolerant in accordance with the perceptual boundary of click trains and of consonant-vowel syllables. The shape of tMTF of those neurons was either band-pass or low-pass. The single click paradigm revealed, at maximum, four response periods in the following order: 1st excitation, 1st suppression, 2nd excitation then 2nd suppression. The 1st excitation and 1st suppression was found exclusively in the synchronization type, implying that the temporal interplay between excitation and suppression underlies stimulus-locking responses. Among these neurons, those showing the 2nd suppression had band-pass tMTF whereas those with low-pass tMTF never showed the 2nd suppression, implying that tMTF shape is mediated through the 2nd suppression. The recovery time course of excitability suggested the involvement of short-term plasticity. The observed phenomena were well captured by a single cell model which incorporated AMPA, GABA_A, NMDA and GABA_Breceptors as well as short-term plasticity of thalamocortical synaptic connections.</p> <p>Conclusion</p> <p>Overall, it was suggested that ISI-dependent responses of the majority of AI neurons are configured through the temporal interplay of excitation and suppression (inhibition) along with short-term plasticity.</p