55,987 research outputs found

    Protein expression and purification of integrin I domains and IgSF ligands for crystallography

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    Magnetotransport and dielectric properties of perovskite ruthenate and titanate thin films

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    2007-2008 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

    Benefits of current percolation in superconducting coated conductors

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    The critical currents of MOD/RABiTS and PLD/IBAD coated conductors have been measured as a function of magnetic field orientation and compared to films grown on single crystal substrates. By varying the orientation of magnetic field applied in the plane of the film, we are able to determine the extent to which current flow in each type of conductor is percolative. Standard MOD/RABiTS conductors have also been compared to samples whose grain boundaries have been doped by diffusing Ca from an overlayer. We find that undoped MOD/RABiTS tapes have a less anisotropic in-plane field dependence than PLD/IBAD tapes and that the uniformity of critical current as a function of in-plane field angle is greater for MOD/RABiTS samples doped with Ca.EPSRC US Department of Energ

    湖北省罗田凤凰关混合岩浅色体的类型及其锆石U-Pb年龄

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    Based on the principle of refolding transecting and overprinting, and eliminating the refolding pseudomorph resulting from the effect of viscous folds, 8-generation leucosomes have been distinguished in the Fenghuangguan migmatites in Luotian, Hubei Province, central China. The results of the major-, trace- and rare earth-element geochemistry indicate that the leucosome for dating the U-Pb age was derived from anatexis. The zircon U-Pb age suggests that there was a migmatization during the Yanshan Period, which may represent an important anatex is at the age, (129. 3 +/- 0. 8) Ma.根据混合岩浅色体的重褶、横切和叠加关系并剔除因粘性褶皱效应引起的重褶皱假象, 在湖北罗田凤凰关识别出8 个世代的浅色体。它们的主量、微量和稀土元素地球化学研究表明, 用于锆石U-Pb 定年的浅色体是深熔成因的。锆石U-Pb 定年结果表明, 在大别杂岩内存在燕山期的混合岩化作用, 其时代为(129.3.8)Ma。published_or_final_versio

    The potential roles of hepatocyte growth factor (HGF)-MET pathway inhibitors in cancer treatment

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    MET is located on chromosome 7q31 and is a proto-oncogene that encodes for hepa-tocyte growth factor (HGF) receptor, a member of the receptor tyrosine kinase (RTK) family. HGF, also known as scatter factor (SF), is the only known ligand for MET. MET is a master regulator of cell growth and division (mitogenesis), mobility (motogenesis), and differentiation (morphogenesis); it plays an important role in normal development and tissue regeneration. The HGF-MET axis is frequently dysregulated in cancer by MET gene amplification, translocation, and mutation, or by MET or HGF protein overexpression. MET dysregulation is associated with an increased propensity for metastatic disease and poor overall prognosis across multiple tumor types. Targeting the dysregulated HGF-MET pathway is an area of active research; a number of monoclonal antibodies to HGF and MET, as well as small molecule inhibitors of MET, are under development. This review summarizes the key biological features of the HGF-MET axis, its dysregulation in cancer, and the therapeutic agents targeting the HGF-MET axis, which are in development. © 2014 Parikh et al

    Regression with Linear Factored Functions

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    Many applications that use empirically estimated functions face a curse of dimensionality, because the integrals over most function classes must be approximated by sampling. This paper introduces a novel regression-algorithm that learns linear factored functions (LFF). This class of functions has structural properties that allow to analytically solve certain integrals and to calculate point-wise products. Applications like belief propagation and reinforcement learning can exploit these properties to break the curse and speed up computation. We derive a regularized greedy optimization scheme, that learns factored basis functions during training. The novel regression algorithm performs competitively to Gaussian processes on benchmark tasks, and the learned LFF functions are with 4-9 factored basis functions on average very compact.Comment: Under review as conference paper at ECML/PKDD 201
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