468 research outputs found
Ambipolar Field Effect in Topological Insulator Nanoplates of (BixSb1-x)2Te3
Topological insulators represent a new state of quantum matter attractive to
both fundamental physics and technological applications such as spintronics and
quantum information processing. In a topological insulator, the bulk energy gap
is traversed by spin-momentum locked surface states forming an odd number of
surface bands that possesses unique electronic properties. However, transport
measurements have often been dominated by residual bulk carriers from crystal
defects or environmental doping which mask the topological surface
contribution. Here we demonstrate (BixSb1-x)2Te3 as a tunable topological
insulator system to manipulate bulk conductivity by varying the Bi/Sb
composition ratio. (BixSb1-x)2Te3 ternary compounds are confirmed as
topological insulators for the entire composition range by angle resolved
photoemission spectroscopy (ARPES) measurements and ab initio calculations.
Additionally, we observe a clear ambipolar gating effect similar to that
observed in graphene using nanoplates of (BixSb1-x)2Te3 in
field-effect-transistor (FET) devices. The manipulation of carrier type and
concentration in topological insulator nanostructures demonstrated in this
study paves the way for implementation of topological insulators in
nanoelectronics and spintronics.Comment: 7 pages, 4 figure
Experimental Demonstration of Five-photon Entanglement and Open-destination Teleportation
Universal quantum error-correction requires the ability of manipulating
entanglement of five or more particles. Although entanglement of three or four
particles has been experimentally demonstrated and used to obtain the extreme
contradiction between quantum mechanics and local realism, the realization of
five-particle entanglement remains an experimental challenge. Meanwhile, a
crucial experimental challenge in multi-party quantum communication and
computation is the so-called open-destination teleportation. During
open-destination teleportation, an unknown quantum state of a single particle
is first teleported onto a N-particle coherent superposition to perform
distributed quantum information processing. At a later stage this teleported
state can be readout at any of the N particles for further applications by
performing a projection measurement on the remaining N-1 particles. Here, we
report a proof-of-principle demonstration of five-photon entanglement and
open-destination teleportation. In the experiment, we use two entangled photon
pairs to generate a four-photon entangled state, which is then combined with a
single photon state to achieve the experimental goals. The methods developed in
our experiment would have various applications e.g. in quantum secret sharing
and measurement-based quantum computation.Comment: 19 pages, 4 figures, submitted for publication on 15 October, 200
Experimental demonstration of a hyper-entangled ten-qubit Schr\"odinger cat state
Coherent manipulation of an increasing number of qubits for the generation of
entangled states has been an important goal and benchmark in the emerging field
of quantum information science. The multiparticle entangled states serve as
physical resources for measurement-based quantum computing and high-precision
quantum metrology. However, their experimental preparation has proved extremely
challenging. To date, entangled states up to six, eight atoms, or six photonic
qubits have been demonstrated. Here, by exploiting both the photons'
polarization and momentum degrees of freedom, we report the creation of
hyper-entangled six-, eight-, and ten-qubit Schr\"odinger cat states. We
characterize the cat states by evaluating their fidelities and detecting the
presence of genuine multi-partite entanglement. Small modifications of the
experimental setup will allow the generation of various graph states up to ten
qubits. Our method provides a shortcut to expand the effective Hilbert space,
opening up interesting applications such as quantum-enhanced super-resolving
phase measurement, graph-state generation for anyonic simulation and
topological error correction, and novel tests of nonlocality with
hyper-entanglement.Comment: 11 pages, 5 figures, comments welcom
New chemolysis for urological calcium phosphate calculi – a study in vitro
BACKGROUND: Advances in techniques have left very few indications for open surgical extraction of urinary stones currently. These advances notwithstanding, the search continues for medical approaches to urinary stone management. In this study, we perform an in vitro study analyzing the efficiency and prospect of two new complex solutions in urological calcium phosphate calculi dissolution. METHODS: Eighteen stones composed mainly of calcium phosphates were taken from patients who underwent kidney stone surgery. These stones were large enough (weight range 0.514–0.928 g) to be fragmented and matched equally into six groups. Chemolysis of phosphate stones was done with six different solvents and was repeated 3 times with 6 stones for each solution. At 24, 48 and 72 h, reduction in weight, percentage weight change, and dissolution rate; the dissolution rates at pH 5.0, 7.0 and 8.5 for each solution, using different cations (Na(+), K(+ )or Ca(2+)), according to different dilutions (1:1, 1:2, 1:3, 1:4) of S1 and S2 were simultaneously determined. RESULTS: Calcium phosphate calculi were poorly dissolved by Phys and Art, and they had a low dissolution rate in pH 8.5 EDTA. The most effective solutions were S1, S2 and R, with 72 h mean dissolution rates: 5.75 ± 0.44 mg/hr (S1), 5.2 ± 0.63 mg/hr (S2), 4.55 ± 0.46 mg/hr (R) ([Image: see text] ± s, p < 0.01 R, S1 and S2 vs Phys, Art and EDTA; p < 0.05, S1 vs R, LSD-test). The mean percentage weight loss at 72 h was: 52.1 ± 15.75 % (S1), 44.4 ± 7.37 % (S2) and 40.5 ± 3.67 % (R) ([Image: see text] ± s, p < 0.01 R, S1 and S2 vs Phys, Art and EDTA, LSD-test). Diluted twice, S1 and S2 had even better effectiveness than their initial solution. The additive of Na(+), K(+ )or Ca(2+ )greatly reduced the dissolution rates of S1, S2. CONCLUSION: Our data indicate that test solutions S1 and S2 are effective solvents in the chemolysis of calcium phosphate stones. At twice dilutions, these solutions are even more useful in the treatment of stone disease
Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses.
Mesenchymal tumor subpopulations secrete pro-tumorigenic cytokines and promote treatment resistance1-4. This phenomenon has been implicated in chemorefractory small cell lung cancer and resistance to targeted therapies5-8, but remains incompletely defined. Here, we identify a subclass of endogenous retroviruses (ERVs) that engages innate immune signaling in these cells. Stimulated 3 prime antisense retroviral coding sequences (SPARCS) are oriented inversely in 3' untranslated regions of specific genes enriched for regulation by STAT1 and EZH2. Derepression of these loci results in double-stranded RNA generation following IFN-γ exposure due to bi-directional transcription from the STAT1-activated gene promoter and the 5' long terminal repeat of the antisense ERV. Engagement of MAVS and STING activates downstream TBK1, IRF3, and STAT1 signaling, sustaining a positive feedback loop. SPARCS induction in human tumors is tightly associated with major histocompatibility complex class 1 expression, mesenchymal markers, and downregulation of chromatin modifying enzymes, including EZH2. Analysis of cell lines with high inducible SPARCS expression reveals strong association with an AXL/MET-positive mesenchymal cell state. While SPARCS-high tumors are immune infiltrated, they also exhibit multiple features of an immune-suppressed microenviroment. Together, these data unveil a subclass of ERVs whose derepression triggers pathologic innate immune signaling in cancer, with important implications for cancer immunotherapy
Simulation of gait asymmetry and energy transfer efficiency between unilateral and bilateral amputees
Efficient walking or running requires symmetrical
gait. Gait symmetry is one of the key factors in efficient
human dynamics, kinematics and kinetics. The desire of individuals with a lower-limb amputation to participate
in sports has resulted in the development of energy-storing and-returning (ESR) feet. This paper analyses a case study
to show the effect of symmetry and asymmetry as well as
energy transfer efficiency during periodic jumping between
simulated bilateral and unilateral runners. A custom gait
analysis system is developed as part of this project to track the motion of the body of a physically active subject during a set of predefined motions. Stance and aerial times are accurately measured using a high speed camera. Gait frequency, the level of symmetry and the non-uniform displacement between left and right foot and their effects on the position of the Centre of Mass (CM) were used as
criteria to calculate both peak energies and transformation
efficiency. Gait asymmetry and discrepancy of energy
transfer efficiency between the intact foot and the ESR are
observed. It is concluded that unilateral runners require
excessive effort to compensate for lack of symmetry as well as asymmetry in energy transfer, causing fatigue which could be a reason why bilateral amputee runners using ESR feet have a superior advantage over unilateral amputees
Phase Diagram and High Temperature Superconductivity at 65 K in Tuning Carrier Concentration of Single-Layer FeSe Films
Superconductivity in the cuprate superconductors and the Fe-based
superconductors is realized by doping the parent compound with charge carriers,
or by application of high pressure, to suppress the antiferromagnetic state.
Such a rich phase diagram is important in understanding superconductivity
mechanism and other physics in the Cu- and Fe-based high temperature
superconductors. In this paper, we report a phase diagram in the single-layer
FeSe films grown on SrTiO3 substrate by an annealing procedure to tune the
charge carrier concentration over a wide range. A dramatic change of the band
structure and Fermi surface is observed, with two distinct phases identified
that are competing during the annealing process. Superconductivity with a
record high transition temperature (Tc) at ~65 K is realized by optimizing the
annealing process. The wide tunability of the system across different phases,
and its high-Tc, make the single-layer FeSe film ideal not only to investigate
the superconductivity physics and mechanism, but also to study novel quantum
phenomena and for potential applications.Comment: 15 pages, 4 figure
Cigarette Smoking and p16INK4α Gene Promoter Hypermethylation in Non-Small Cell Lung Carcinoma Patients: A Meta-Analysis
BACKGROUND:Aberrant methylation of promoter DNA and transcriptional repression of specific tumor suppressor genes play an important role in carcinogenesis. Recently, many studies have investigated the association between cigarette smoking and p16(INK4α) gene hypermethylation in lung cancer, but could not reach a unanimous conclusion. METHODS AND FINDINGS:Nineteen cross-sectional studies on the association between cigarette smoking and p16(INK4α) methylation in surgically resected tumor tissues from non-small cell lung carcinoma (NSCLC) patients were identified in PubMed database until June 2011. For each study, a 2×2 cross-table was extracted. In total, 2,037 smoker and 765 nonsmoker patients were pooled with a fixed-effects model weighting for the inverse of the variance. Overall, the frequency of p16(INK4α) hypermethylation was higher in NSCLC patients with smoking habits than that in non-smoking patients (OR = 2.25, 95% CI = 1.81-2.80). The positive association between cigarette smoking and p16(INK4α) hypermethylation was similar in adenocarcinoma and squamous-cell carcinoma. In the stratified analyses, the association was stronger in Asian patients and in the studies with larger sample sizes. CONCLUSION:Cigarette smoking is positively correlated to p16(INK4α) gene hypermethylation in NSCLC patients
The Effect of Chronic Antipsychotic Drug on Hypothalamic Expression of Neural Nitric Oxide Synthase and Dopamine D2 Receptor in the Male Rat
Antipsychotic-induced sexual dysfunction is a common and serious clinical side effect. It has been demonstrated that both neuronal nitric oxide (nNOS) and dopamine D2 receptor (DRD2) in the medial preoptic area (MPOA) and the paraventricular nucleus (PVN) of the hypothalamus have important roles in the regulation of sexual behaviour. We investigated the influences of 21 days’ antipsychotic drug administration on expression of nNOS and DRD2 in the rat hypothalamus. Haloperidol (0.5 mg/kg/day i.p.) significantly decreased nNOS integrated optical density in a sub-nucleus of the MPOA, medial preoptic nucleus (MPN), and decreased the nNOS integrated optical density and cell density in another sub-nucleus of the MPOA, anterodorsal preoptic nucleus (ADP). Risperidone (0.25 mg/kg) inhibited the nNOS integrated optical density in the ADP. nNOS mRNA and protein in the MPOA but not the PVN was also significantly decreased by haloperidol. Haloperidol and risperidone increased DRD2 mRNA and protein expression in both the MPOA and the PVN. Quetiapine (20 mg/kg/day i.p.) did not influence the expression of nNOS and DRD2 in either the MPOA or the PVN. These findings indicate that hypothalamic nNOS and DRD2 are affected to different extents by chronic administration of risperidone and haloperidol, but are unaffected by quetiapine. These central effects might play a role in sexual dysfunction induced by certain antipsychotic drugs
- …