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Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction.
Sirt1 is an NAD-dependent, class III deacetylase that functions as a cellular energy sensor. In addition to its well-characterized effects in peripheral tissues, emerging evidence suggests that neuronal Sirt1 activity plays a role in the central regulation of energy balance and glucose metabolism. In this study, we generated mice expressing an enzymatically inactive form (N-MUT) or wild-type (WT) SIRT1 (N-OX) in mature neurons. N-OX male and female mice had impaired glucose tolerance, and N-MUT female, but not male, mice had improved glucose tolerance compared with that of WT littermates. Furthermore, glucose tolerance was improved in all mice with caloric restriction (CR) but was greater in the N-OX mice, who had better glucose tolerance than their littermates. At the reproductive level, N-OX females had impaired estrous cycles, with increased cycle length and more time in estrus. LH and progesterone surges were absent on the evening of proestrus in the N-OX mice, suggesting a defect in spontaneous ovulation, which was confirmed by the ovarian histology revealing fewer corpora lutea. Despite this defect, the mice were still fertile when mated to WT mice on the day of proestrus, indicating that the mice could respond to normal pheromonal or environmental cues. When subjected to CR, the N-OX mice went into diestrus arrest earlier than their littermates. Together, these results suggested that the overexpression of SIRT1 rendered the mice more sensitive to the metabolic improvements and suppression of reproductive cycles by CR, which was independent of circadian rhythms
Electrochemical Investigation of Exchange Current Density of Uranium and Rare-earths Couples (M3+/M0) in LiCl-KCl Eutectic Electrolyte
The objective of this work is to use electrochemical techniques to quantify the electrode reaction rate of some rare-earth elements and uranium in a LiCl-KCl eutectic electrolyte at 500oC. The exchange current densities of the oxidation-reduction couples of M3+/M0 (La3+/La0, Ce3+/Ce0, Pr3+/Pr0, Nd3+/Nd0,Gd3+/Gd0, Y3+/Y0, U3+/U0) on a tungsten electrode were measured by applying a linear polarization resistance technique. A region of linear dependence of potential on applied current could be found to describe the reaction rate of oxidation-reduction system. From these measurements, the estimated exchange current density was 0.38 mA/cm2 for uranium, and was within the range of 0.27 to 0.38mA/cm2 for rare-earth elements.open0
Successive spin-flop transitions of a Neel-type antiferromagnet Li2MnO3 single crystal with a honeycomb lattice
We have carried out high magnetic field studies of single-crystalline Li2MnO3, a honeycomb lattice antiferromagnet. Its magnetic phase diagram was mapped out using magnetization measurements at applied fields up to 35 T. Our results show that it undergoes two successive meta-magnetic transitions around 9 T fields applied perpendicular to the ab plane (along the c* axis). These phase transitions are completely absent in the magnetization measured with the field applied along the ab plane. In order to understand this magnetic phase diagram, we developed a mean-field model starting from the correct Neel-type magnetic structure, consistent with our single crystal neutron diffraction data at zero field. Our model calculations succeeded in explaining the two meta-magnetic transitions that arise when Li2MnO3 enters two different spin-flop phases from the zero field Neel phase.open1187Nsciescopu
Phenomenological Implications of Deflected Mirage Mediation: Comparison with Mirage Mediation
We compare the collider phenomenology of mirage mediation and deflected
mirage mediation, which are two recently proposed "mixed" supersymmetry
breaking scenarios motivated from string compactifications. The scenarios
differ in that deflected mirage mediation includes contributions from gauge
mediation in addition to the contributions from gravity mediation and anomaly
mediation also present in mirage mediation. The threshold effects from gauge
mediation can drastically alter the low energy spectrum from that of pure
mirage mediation models, resulting in some cases in a squeezed gaugino spectrum
and a gluino that is much lighter than other colored superpartners. We provide
several benchmark deflected mirage mediation models and construct model lines
as a function of the gauge mediation contributions, and discuss their discovery
potential at the LHC.Comment: 29 pages, 9 figure
Improved Glaucoma Medication Access Through Pharmacy Partnership: A Single Institution Experience
Jin G Choi,1,2 Pathik Amin,3 Alaina Tarantino,4 Mary Qiu3 1Pritzker School of Medicine, University of Chicago, Chicago, IL, USA; 2Department of Ophthalmology, California Pacific Medical Center, San Francisco, CA, USA; 3Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, USA; 4Ambulatory Pharmacy Services, University of Chicago, Chicago, IL, USACorrespondence: Mary Qiu, Department of Ophthalmology and Visual Science, University of Chicago, Chicago, IL, USA, Tel +1 (773) 702-3937, Email [email protected]: A major barrier to glaucoma medication adherence is the patient’s out-of-pocket costs. At the University of Chicago Medical Center (UCMC), the institutional pharmacy piloted a program to query out-of-pocket costs for each patient’s medication list based on their insurance coverage. This study aims to describe the impact of this collaboration between the glaucoma service and the outpatient pharmacy service.Methods: This study is a single institution, retrospective chart review of glaucoma patients with a formulary inquiry placed by a single glaucoma specialist between 4/1/2020 and 2/28/2022. Main outcome measures included medications before and after formulary inquiries, additional steps required to access the medications (ie, formulary exceptions, prior authorizations, tier exceptions), and out-of-pocket costs.Results: A total of 343 formulary inquiries, representing 568 individual medication inquiries, were conducted. Out of the 568 medication inquiries, only 78 could be filled for an affordable price without any additional steps. For 45 inquiries, additional steps were required for the medication to become covered at an affordable price. The remaining 445 inquires required additional steps with subsequent denial or prohibitive out-of-pocket costs.Conclusion: The UCMC workflow provided transparent out-of-pocket costs for patients to access glaucoma medications. This workflow may be cost-effective as it minimizes the burden on the overall system by reducing the number of patients who are unable to fill a prescription at the pharmacy due to issues with coverage or affordability. This model of physician-pharmacy collaboration can guide other institutions to implement similar workflows which directly mitigate costs and improve quality of care.Keywords: medication, access, cos
Influence of prohexadione-calcium, trinexapac-ethyl and hexaconazole on lodging characteristic and gibberellin biosynthesis of rice (Oryza sativa L.)
We investigated the influence of prohexadione-calcium (Pro-Ca), trinexapac-ethyl (TNE) and hexaconazole (HX) on lodging and gibberellin (GA) biosynthesis pathway of rice cultivar, Hwayeongbyeo. It was observed that these novel synthetic growth retardants suppressed lodging of rice under field conditions through blocking GA biosynthesis pathway. These growth retarding chemicals were applied at basic (20 uM) and elevated (40 uM) rates either 10 days before heading (10 DBH) or 5 days before heading (5 DBH). We found that Pro-Ca, TNE and their combined application (Pro-Ca + TNE) were most effective in decreasing rice length and lodging index, when applied at 10 DBH. Similarly, the endogenous bioactive GA1 contents of rice significantly declined with application of Pro-Ca, TNE and Pro-Ca + TNE, while they were less effected by basic and elevated rates of HX as compared to the control. The growth retardants were more effective in decreasing rice lodging and blocking GA biosynthesis when applied in elevated rates. The levels of the endogenous gibberellins in rice shoots were measured by GC/MS-SIM using 2H2-labeled gibberellins as internal standards. Effect of these synthetic chemicals on growth and GA inhibition were stronger initially but eroded rapidly under field conditions. It was thus concluded that Pro-Ca and TNE were most effective in reducing plant length and suppressing lodging of rice crop under field conditions, where lodging is a major constraint to higher productivity.Key words: Growth retardants, plant growth, gibberellin biosynthesis, lodging index, rice
Visualization of vortex motion in FeAs-based BaFe<inf>1.9</inf>Ni <inf>0.1</inf>As<inf>2</inf> single crystal by means of magneto-optical imaging
Superconductivity has been found in newly discovered iron-based compounds. This paper studies the motion of magnetic vortices in BaFe1.9Ni 0.1As2 single crystal by means of the magneto-optical imaging technique. A series of magneto-optical images reflecting magnetic flux distribution at the crystal surface were taken when the crystal was zero-field cooled to 10 K. The behavior of the vortices, including penetration into and expulsion from the single crystal with increasing and decreasing external fields, respectively, is discussed. The motion behavior is similar to that observed in high-Tc superconducting cuprates with strong vortex pinning; however, the flux-front is irregular due to randomly distributed defects in the crystal. © 2011 American Institute of Physics
Direct Evidence for Dominant Bond-directional Interactions in a Honeycomb Lattice Iridate Na2IrO3
Heisenberg interactions are ubiquitous in magnetic materials and have been
prevailing in modeling and designing quantum magnets. Bond-directional
interactions offer a novel alternative to Heisenberg exchange and provide the
building blocks of the Kitaev model, which has a quantum spin liquid (QSL) as
its exact ground state. Honeycomb iridates, A2IrO3 (A=Na,Li), offer potential
realizations of the Kitaev model, and their reported magnetic behaviors may be
interpreted within the Kitaev framework. However, the extent of their relevance
to the Kitaev model remains unclear, as evidence for bond-directional
interactions remains indirect or conjectural. Here, we present direct evidence
for dominant bond-directional interactions in antiferromagnetic Na2IrO3 and
show that they lead to strong magnetic frustration. Diffuse magnetic x-ray
scattering reveals broken spin-rotational symmetry even above Neel temperature,
with the three spin components exhibiting nano-scale correlations along
distinct crystallographic directions. This spin-space and real-space
entanglement directly manifests the bond-directional interactions, provides the
missing link to Kitaev physics in honeycomb iridates, and establishes a new
design strategy toward frustrated magnetism.Comment: Nature Physics, accepted (2015
Use of a porous membrane for gas bubble removal in microfluidic channels: physical mechanisms and design criteria
We demonstrate and explain a simple and efficient way to remove gas bubbles
from liquid-filled microchannels, by integrating a hydrophobic porous membrane
on top of the microchannel. A prototype chip is manufactured in hard,
transparent polymer with the ability to completely filter gas plugs out of a
segmented flow at rates up to 7.4 microliter/s per mm2 of membrane area. The
device involves a bubble generation section and a gas removal section. In the
bubble generation section, a T-junction is used to generate a train of gas
plugs into a water stream. These gas plugs are then transported towards the gas
removal section, where they slide along a hydrophobic membrane until complete
removal. The system has been successfully modeled and four necessary operating
criteria have been determined to achieve a complete separation of the gas from
the liquid. The first criterion is that the bubble length needs to be larger
than the channel diameter. The second criterion is that the gas plug should
stay on the membrane for a time sufficient to transport all the gas through the
membrane. The third criterion is that the gas plug travel speed should be lower
than a critical value: otherwise a stable liquid film between the bubble and
the membrane prevents mass transfer. The fourth criterion is that the pressure
difference across the membrane should not be larger than the Laplace pressure
to prevent water from leaking through the membrane
Shortcuts to adiabaticity in a time-dependent box
A method is proposed to drive an ultrafast non-adiabatic dynamics of an
ultracold gas trapped in a box potential. The resulting state is free from
spurious excitations associated with the breakdown of adiabaticity, and
preserves the quantum correlations of the initial state up to a scaling factor.
The process relies on the existence of an adiabatic invariant and the inversion
of the dynamical self-similar scaling law dictated by it. Its physical
implementation generally requires the use of an auxiliary expulsive potential
analogous to those used in soliton control. The method is extended to a broad
family of many-body systems. As illustrative examples we consider the ultrafast
expansion of a Tonks-Girardeau gas and of Bose-Einstein condensates in
different dimensions, where the method exhibits an excellent robustness against
different regimes of interactions and the features of an experimentally
realizable box potential.Comment: 6 pp, 4 figures, typo in Eq. (6) fixe
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