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From Open to Secret Ballot: Vote Buying and Modernization
The secret ballot is one of the cornerstones of democracy. We contend that the historical process of modernization caused the switch from open to secret ballot with the underlying mechanism being that income growth, urbanization, and rising education standards undermined vote markets and made electoral corruption uneconomical. We undertake event history studies of ballot reform in Western Europe and the Americas during the 19th and 20th centuries to establish that modernization was systematically related to ballot reform. We study electoral turnout before and after ballot reform amongst the US states and British parliamentary constituencies to substantiate the hypothesis that modernization made vote buying uneconomical
Spinal degeneration is associated with lumbar multifidus morphology in secondary care patients with low back or leg pain
Associations between multifidus muscle morphology and degenerative pathologies have been implied in patients with non-specific low back pain, but it is unknown how these are influenced by pathology severity, number, or distribution. MRI measures of pure multifidus muscle cross-sectional area (CSA) were acquired from 522 patients presenting with low back and/or leg symptoms in an outpatient clinic. We explored cross-sectional associations between the presence, distribution, and/or severity of lumbar degenerative pathologies (individually and in aggregate) and muscle outcomes in multivariable analyses (beta coefficients [95% CI]). We identified associations between lower pure multifidus muscle CSA and disc degeneration (at two or more levels): − 4.51 [− 6.72; − 2.3], Modic 2 changes: − 4.06 [− 6.09; − 2.04], endplate defects: − 2.74 [− 4.58; − 0.91], facet arthrosis: − 4.02 [− 6.26; − 1.78], disc herniations: − 3.66 [− 5.8; − 1.52], and when > 5 pathologies were present: − 6.77 [− 9.76; − 3.77], with the last supporting a potential dose–response relationship between number of spinal pathologies and multifidus morphology. Our findings could hypothetically indicate that these spinal and muscle findings: (1) are part of the same degenerative process, (2) result from prior injury or other common antecedent events, or (3) have a directional relationship. Future longitudinal studies are needed to further examine the complex nature of these relationships
Fusion of SpCas9 to E.coli Rec A protein enhances CRISPR-Cas9 mediated gene knockout in mammalian cells
Mammalian cells repair double-strand DNA breaks (DSB) by a range of different pathways following DSB induction by the engineered clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein Cas9. While CRISPR-Cas9 thus enables predesigned modifications of the genome, applications of CRISPR-Cas9-mediated genome-editing are frequently hampered by the unpredictable and varying pathways for DSB repair in mammalian cells. Here we present a strategy of fusing Cas9 to recombinant proteins for fine-tuning of the DSB repair preferences in mammalian cells. By fusing Streptococcus Pyogenes Cas9 (SpCas9) to the recombinant protein A (Rec A, NP_417179.1) from E. coli, we create a recombinant Cas9 protein (rSpCas9) which enhances the generation of indel mutations at DSB sites in mammalian cells, increases the frequency of DSB repair by homology-directed single-strand annealing (SSA), and represses homology-directed gene conversion by approximately 33%. Our study thus proves for the first time that fusing SpCas9 to recombinant proteins can influence the balance between DSB repair pathways in mammalian cells. This approach may form the basis for further investigations of the applications of recombinant Cas9 proteins to fine-tuning DSB repair pathways in eukaryotic cells
Superradiation from Crystals of High-Spin Molecular Nanomagnets
Phenomenological theory of superradiation from crystals of high-spin
molecules is suggested. We show that radiation friction can cause a
superradiation pulse and investigate the role of magnetic anisotropy, external
magnetic field and dipole-dipole interactions. Depending on the contribution of
all these factors at low temperature, several regimes of magnetization of
crystal sample are described. Very fast switch of magnetization's direction for
some sets of parameters is predicted.Comment: 10 pages, 3 figure
Assessing lumbar paraspinal muscle cross-sectional area and fat composition with T1 versus T2-weighted magnetic resonance imaging: Reliability and concurrent validity
Purpose
Studies using magnetic resonance imaging to assess lumbar multifidus cross-sectional area frequently utilize T1 or T2-weighted sequences, but seldom provide the rationale for their sequence choice. However, technical considerations between their acquisition protocols could impact on the ability to assess lumbar multifidus anatomy or its fat/muscle distinction. Our objectives were to examine the concurrent validity of lumbar multifidus morphology measures of T2 compared to T1-weighted sequences, and to assess the reliability of repeated lumbar multifidus measures.
Methods
The lumbar multifidus total cross-sectional area of 45 patients was measured bilaterally at L4 and L5, with histogram analysis determining the muscle/fat threshold values per muscle. Images were later re-randomized and re-assessed for intra-rater reliability. Matched images were visually rated for consistency of outlining between both image sequences. Bland-Altman bias, limits of agreement, and plots were calculated for differences in total cross-sectional area and percentage fat between and within sequences, and intra-rater reliability analysed.
Results
T1-weighted total cross-sectional area measures were systematically larger than T2 (0.2 cm2), with limits of agreement <±10% at both spinal levels. For percentage fat, no systematic bias occurred, but limits of agreement approached ±15%. Visually, muscle outlining was consistent between sequences, with substantial mismatches occurring in <5% of cases. Intra-rater reliability was excellent (ICC: 0.981–0.998); with bias and limits of agreement less than 1% and ±5%, respectively.
Conclusion
Total cross-sectional area measures and outlining of muscle boundaries were consistent between sequences, and intra-rater reliability for total cross-sectional area and percentage fat was high indicating that either MRI sequence could be used interchangeably for this purpose. However, further studies comparing the accuracy of various methods for distinguishing fat from muscle are recommended
Analytical approximation of the stress-energy tensor of a quantized scalar field in static spherically symmetric spacetimes
Analytical approximations for and of a
quantized scalar field in static spherically symmetric spacetimes are obtained.
The field is assumed to be both massive and massless, with an arbitrary
coupling to the scalar curvature, and in a zero temperature vacuum state.
The expressions for and are divided into
low- and high-frequency parts. The contributions of the high-frequency modes to
these quantities are calculated for an arbitrary quantum state. As an example,
the low-frequency contributions to and are
calculated in asymptotically flat spacetimes in a quantum state corresponding
to the Minkowski vacuum (Boulware quantum state). The limits of the
applicability of these approximations are discussed.Comment: revtex4, 17 pages; v2: three references adde
Structural Routability of n-Pairs Information Networks
Information does not generally behave like a conservative fluid flow in
communication networks with multiple sources and sinks. However, it is often
conceptually and practically useful to be able to associate separate data
streams with each source-sink pair, with only routing and no coding performed
at the network nodes. This raises the question of whether there is a nontrivial
class of network topologies for which achievability is always equivalent to
routability, for any combination of source signals and positive channel
capacities. This chapter considers possibly cyclic, directed, errorless
networks with n source-sink pairs and mutually independent source signals. The
concept of downward dominance is introduced and it is shown that, if the
network topology is downward dominated, then the achievability of a given
combination of source signals and channel capacities implies the existence of a
feasible multicommodity flow.Comment: The final publication is available at link.springer.com
http://link.springer.com/chapter/10.1007/978-3-319-02150-8_
Method to compute the stress-energy tensor for the massless spin 1/2 field in a general static spherically symmetric spacetime
A method for computing the stress-energy tensor for the quantized, massless,
spin 1/2 field in a general static spherically symmetric spacetime is
presented. The field can be in a zero temperature state or a non-zero
temperature thermal state. An expression for the full renormalized
stress-energy tensor is derived. It consists of a sum of two tensors both of
which are conserved. One tensor is written in terms of the modes of the
quantized field and has zero trace. In most cases it must be computed
numerically. The other tensor does not explicitly depend on the modes and has a
trace equal to the trace anomaly. It can be used as an analytic approximation
for the stress-energy tensor and is equivalent to other approximations that
have been made for the stress-energy tensor of the massless spin 1/2 field in
static spherically symmetric spacetimes.Comment: 34 pages, no figure
A comment on multiple vacua, particle production and the time dependent AdS/CFT correspondence
We give an explicit formulation of the time dependent AdS/CFT correspondence
when there are multiple vacua present in Lorentzian signature. By computing
sample two point functions we show how different amplitudes are related by
cosmological particle production. We illustrate our methods in two example
spacetimes: (a) a ``bubble of nothing'' in AdS space, and (b) an asymptotically
locally AdS spacetime with a bubble of nothing on the boundary. In both cases
the alpha vacua of de Sitter space make an interesting appearance.Comment: 9 page
Chiral unitary approach to S-wave meson baryon scattering in the strangeness S=0 sector
We study the S-wave interaction of mesons with baryons in the strangeness S=0
sector in a coupled channel unitary approach. The basic dynamics is drawn from
the lowest order meson baryon chiral Lagrangians. Small modifications inspired
by models with explicit vector meson exchange in the t-channel are also
considered. In addition the pi pi N channel is included and shown to have an
important repercussion in the results, particularly in the isospin 3/2 sector.Comment: 23 pages, LaTeX, 21 figure
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