Hydrodynamic Irreversibility in Particle Suspensions with Non-Uniform Strain

A dynamical phase transition from reversible to irreversible behavior occurs when particle suspensions are subjected to uniform oscillatory shear, even in the Stokes flow limit. We consider a more general situation with non-uniform strain (e.g. oscillatory channel flow), which is observed to exhibit markedly different dynamics. Self-organization and shear-induced migration only partially explain the delayed, simultaneous onset of irreversibility across the channel. The onset of irreversibility is accompanied by long-range correlated particle motion. This motion leads to particle activity even at the channel center, where the strain is negligible, and prevents the system from evolving into a reversible state

Strategies for pricing publicly provided health services

The authors examine how governments finance and allocate public spending, with an eye to developing strategies for pricing publicly provided health services. They also examine the implications of current policy and the possibility for rationalizing competing government priorities. Because governments face budget constraints and cannot fully subsidize all programs and activities, the authors argue the following: a) Public spending on health can (1) improve health outcomes, (2) promote nonhealth aspects of well-being (for example, reducing individuals'risk of economic losses from random health crises), and (3) finance redistribution to the poor. Optimal subsidy and fee policy will depend on how much relative weight government places on those competing objectives. Subsidies need to be reallocated toward the poor and toward public health sector can financed by increasing public subsidies. b) Prices for curative services (user fee) have two distinct roles. They can raise revenue, freeing public resources to be reallocated to public health activities and for limited cofinancing to improve the quality of curative care. More important, they can improve efficiency in the use of public facilities and the health care system as a whole. But those gains must be weighed against evidence that increased fees can compromise public health's three main goals. The literature has focused largely on how raising revenue affects the poor, but the more important effect is likely to be the guidance of resources. User fees are important in cofinancing health care but shouldn't be the primary means of finance. c) Revenue generated from user fees is sometimes used to improve the quality of, and access to, curative medical care. There is some evidence that people are willing to pay some of the cost of improving health care (especially for drugs), but the wealthy are willing to pay a lot more than the poor. If governments charge the average"willingness to pay,"the wealthy will use the services more, the poor, less. d) Prepayment social insurance plans hold promise, but there is evidence that they may introduce inefficient inflation of medical care costs that lower- and middle- income countries cannot afford.Public Sector Economics&Finance,Health Systems Development&Reform,Environmental Economics&Policies,Payment Systems&Infrastructure,Health Economics&Finance,Environmental Economics&Policies,Public Sector Economics&Finance,Health Systems Development&Reform,Health Economics&Finance,Urban Economics

Responses of Hyalella azteca and Ceridaphnia dubia to reservoir sediments following Chelated Copper Herbicide Applications

In response to nuisance growths of algae and vascular plants, such as dioecious hydrilla ( Hydrilla verticillata L.f. Royle), copper formulations have been applied in lakes and reservoirs for a number of years. Concerns have arisen regarding the long-term consequences of copper applications and those concerns have appropriately focused on sediment residues. In this study, we evaluated the toxicity of sediments from treated (for a decade) and untreated areas in Lake Murray, South Carolina and estimated the capacity of those sediments to bind additional copper. Two sentinel aquatic invertebrates, Hyalella azteca Saussure and Ceriodaphnia dubia Richard, were used to measure residual toxicity of treated and untreated sediments from the field and after laboratory amendments. (PDF has 5 pages.

Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy

Adenine nucleotides (AdNs: ATP, ADP, AMP) are essential biological compounds that facilitate many necessary cellular processes by providing chemical energy, mediating intracellular signaling, and regulating protein metabolism and solubilization. A dramatic reduction in total AdNs is observed in atrophic skeletal muscle across numerous disease states and conditions, such as cancer, diabetes, chronic kidney disease, heart failure, COPD, sepsis, muscular dystrophy, denervation, disuse, and sarcopenia. The reduced AdNs in atrophic skeletal muscle are accompanied by increased expression/activities of AdN degrading enzymes and the accumulation of degradation products (IMP, hypoxanthine, xanthine, uric acid), suggesting that the lower AdN content is largely the result of increased nucleotide degradation. Furthermore, this characteristic decrease of AdNs suggests that increased nucleotide degradation contributes to the general pathophysiology of skeletal muscle atrophy. In view of the numerous energetic, and non-energetic, roles of AdNs in skeletal muscle, investigations into the physiological consequences of AdN degradation may provide valuable insight into the mechanisms of muscle atrophy

The magnesium sulfate-water system at pressures to 4 kilobars

Hydrated magnesium sulfate constitutes up to 1/6 of the mass of carbonaceous chondrites, and probably is important in many icy asteroids and satellites. It occurs naturally in meteorites mostly as epsomite. MgSO4, considered anhydrously, comprises nearly 3/4 of the highly soluble fraction of C1 chondrites. Thus, MgSO4 is probably an important solute in cryovolcanic brines erupted on certain icy objects in the outer solar system. While the physiochemical properties of the water-magnesium sulfate system are well known at low pressures, planetological applications of these data are hindered by a dearth of useful published data at elevated pressures. Accordingly, solid-liquid phase equilibria was recently explored in this chemical system at pressures extending to about 4 kilobars. The water magnesium sulfate system in the region of the eutectic exhibits qualitatively constant behavior between pressures of 1 atm and 2 kbar. The eutectic melting curve closely follows that for water ice, with a freezing point depression of about 4 K at 1 atm decreasing to around 3.3 K at 2 kbars. The eutectic shifts from 17 pct. MgSO4 at 1 atm to about 15.3 pct at 2 kbars. Above 2 kbars, the eutectic melting curve again tends to follow ice

Bifurcations of piecewise smooth flows:perspectives, methodologies and open problems

In this paper, the theory of bifurcations in piecewise smooth flows is critically surveyed. The focus is on results that hold in arbitrarily (but finitely) many dimensions, highlighting significant areas where a detailed understanding is presently lacking. The clearest results to date concern equilibria undergoing bifurcations at switching boundaries, and limit cycles undergoing grazing and sliding bifurcations. After discussing fundamental concepts, such as topological equivalence of two piecewise smooth systems, discontinuity-induced bifurcations are defined for equilibria and limit cycles. Conditions for equilibria to exist in n-dimensions are given, followed by the conditions under which they generically undergo codimension-one bifurcations. The extent of knowledge of their unfoldings is also summarized. Codimension-one bifurcations of limit cycles and boundary-intersection crossing are described together with techniques for their classification. Codimension-two bifurcations are discussed with suggestions for further study