A multicomponent intervention for the management of chronic pain in older adults: study protocol for a randomized controlled trial

Background: Studies have shown that physical interventions and psychological methods based on the cognitive behavioral approach are efficacious in alleviating pain and that combining both tends to yield more benefits than either intervention alone. In view of the aging population with chronic pain and the lack of evidence-based pain management programs locally, we developed a multicomponent intervention incorporating physical exercise and cognitive behavioral techniques and examined its long-term effects against treatment as usual (i.e., pain education) in older adults with chronic musculoskeletal pain in Hong Kong. Methods/design: We are conducting a double-blind, cluster-randomized controlled trial. A sample of 160 participants aged ≥ 60 years will be recruited from social centers or outpatient clinics and will be randomized on the basis of center/clinic to either the multicomponent intervention or the pain education program. Both interventions consist of ten weekly sessions of 90 minutes each. The primary outcome is pain intensity, and the secondary outcomes include pain interference, pain persistence, pain self-efficacy, pain coping, pain catastrophizing cognitions, health-related quality of life, depressive symptoms, and hip and knee muscle strength. All outcome measures will be collected at baseline, postintervention, and at 3 and 6 months follow-up. Intention-to-treat analysis will be performed using mixed-effects regression to see whether the multicomponent intervention alleviates pain intensity and associated outcomes over and above the effects of pain education (i.e., a treatment × time intervention effect). Discussion: Because the activities included in the multicomponent intervention were carefully selected for ready implementation by allied health professionals in general, the results of this study, if positive, will make available an efficacious, nonpharmacological pain management program that can be widely adopted in clinical and social service settings and will hence improve older people’s access to pain management services

A review of intelligent approaches for designing dynamic and robust layouts in flexible manufacturing systems

Facility layout problem is associated with the arrangement of facilities in a plant. It is a critical issue in the early stages of designing a manufacturing system because it affects the total manufacturing cost significantly. Dynamic and robust layouts are flexible enough to cope with fluctuations and uncertainties in product demands in volatile environment of flexible manufacturing systems. Since the facility layout is a hard combinatorial optimization problem, intelligent approaches are the most appropriate methods for solving the large size of this problem in reasonable computational time. In this paper, first of all, dynamic and robust layouts are surveyed. After a quick look of different mathematical models, including quadratic assignment, quadratic set covering, mixed integer programming, and graph theoretic models, the various solution methods especially intelligent approaches along with their advantages and disadvantages are surveyed. Finally, after review of hybrid algorithms, the conclusion of this paper is reported