Chronicity and Mental Health Service Utilization for Anxiety, Mood, and Substance Use Disorders among Black Men in the United States; Ethnicity and Nativity Differences.

This study investigated ethnic and nativity differences in the chronicity and treatment of psychiatric disorders of African American and Caribbean Black men in the U.S. Data were analyzed from the National Survey of American Life, a population-based study which included 1859 self-identified Black men (1222 African American, 176 Caribbean Black men born within the U.S., and 461 Caribbean Black men born outside the U.S.). Lifetime and twelve-month prevalence of DSM-IV mood, anxiety, and substance use disorders (including Bipolar I and Dysthmia), disorder chronicity, and rate of mental health services use among those meeting criteria for a lifetime psychiatric disorder were examined. Logistic regression models were employed to determine ethnic differences in chronicity, and treatment utilization for disorders. While rates of DSM-IV disorders were generally low in this community sample of Black men, their disorders were chronic and remained untreated. Caribbean Black men born in the U.S. had higher prevalence of Post-Traumatic Stress Disorder, Major Depressive Disorder, and Alcohol Abuse Disorder compared with African American men. Foreign born Caribbean Black men experienced greater chronicity in Social Phobia and Generalized Anxiety Disorder compared to other Black Men. Utilization of mental health service was low for all groups of Black Men, but lowest for the foreign born Caribbean Black men. Results underscore the large unmet needs of both African American and Caribbean Black men in the United States. Results also highlight the role of ethnicity and nativity in mental disorder chronicity and mental health service utilization patterns of Black men

Thermal consequences of lithospheric extension: Pure and simple

Simple shear and pure shear extension of the lithosphere produce very different patterns of heat flow and topography. These differences are investigated using a numerical technique which solves for two-dimensional conductive and advective heat transport through time. Simple shear extension of the lithosphere is modeled as occurring along a straight shear zone. Two parameters define the simple shear model: the dip of the shear zone and its width. Likewise, the pure shear model is defined by two variables: the initial width of a vertical zone of pure shear extension and the rate of change of its width. These pairs of parameters are varied between calculations, as is the overall rate of extension. Each model results in distinct patterns of crustal thinning, lithospheric thermal structure, heat flow, thermal uplift, crustal subsidence, and topography. For the simple shear model, extension results in asymmetric uplift across the rift, while the total volume of uplift is limited by the total amount of extension. The peak heat flow and thermal uplift are centered over the intersection of the shear zone with the surface. Isostatic response to simple shear extension results in successive, formerly active shear zones being rotated into listric faults which sole into a sub-horizontal detachment. The pure shear results show that the surface heat flow is greater for smaller widths of the zone of extension. For the same overall extension rate, a pure shear model with a narrow zone of extension can result in pressure release melting of the mantle long before low angle simple shear models. These results are compared with topographic and heat flow data from the northern Red Sea rift, a Neogene continental rift which is close to initiating seafloor spreading. The long wavelength topographic asymmetry across the Red Sea, which has been cited as evidence for simple shear extension of the lithosphere, is not matched by any of the models. The observed high heat flow anomalies in the Red Sea require a large component of pure shear lithospheric extension centered under the region of maximum crustal extension. In contrast, at the plate separation rate of the northern Red Sea, simple shear extension of the lithosphere along a shallow ( <30° ) dip detachment is ineffective in reproducing the observed heat flow anomalies. Only a narrowing region of pure shear extension can satisfy the width of the rift, and the peak heat flow values and generate pressure release meltin

Conrad Deep: a new northern Red Sea deep. Origin and implications for continental rifting

A previously unknown deep, here called Conrad Deep, was discovered during an extensive geophysical survey of the northern Red Sea in June, 1984. Conrad Deep is located at 27°03’N, 34°43’E, only 90 km south of the Gulf of Suez and is the most northern deep yet discovered in the Red Sea. It is located within a well developed axial depression which also contains Charcot Deep, 100 km to the south. The axial depression is associated with abundant recent deformation and is situated at the peak of a regional heat flow high extending across the rift. Conrad Deep is typical of the small northern type Red Sea Deep. It is 10 km long, 2 km wide and has a maximum depth of 1460 m. It is associated with high and variable heat flow values and large magnetic anomalies. There is no evidence of a dense brine layer. Detailed analysis of the geophysical data implies that the deep probably results from a very recent (< 40,000 years) intrusion into continental type basement. The formation of a well defined axial depression associated with very high heat flow and small deeps resulting from isolated intrusions may be the first step in the transition from continental extension to seafloor spreading

Disorder-Driven Pretransitional Tweed in Martensitic Transformations

Defying the conventional wisdom regarding first--order transitions, {\it solid--solid displacive transformations} are often accompanied by pronounced pretransitional phenomena. Generally, these phenomena are indicative of some mesoscopic lattice deformation that ``anticipates'' the upcoming phase transition. Among these precursive effects is the observation of the so-called ``tweed'' pattern in transmission electron microscopy in a wide variety of materials. We have investigated the tweed deformation in a two dimensional model system, and found that it arises because the compositional disorder intrinsic to any alloy conspires with the natural geometric constraints of the lattice to produce a frustrated, glassy phase. The predicted phase diagram and glassy behavior have been verified by numerical simulations, and diffraction patterns of simulated systems are found to compare well with experimental data. Analytically comparing to alternative models of strain-disorder coupling, we show that the present model best accounts for experimental observations.Comment: 43 pages in TeX, plus figures. Most figures supplied separately in uuencoded format. Three other figures available via anonymous ftp

The Ursinus Weekly, March 16, 1972

Ursinus graduate appointed assistant Conference Minister • Ursinus Meistersingers plan 34th annual tour • Ursinus math team ranked in top 20 • Freshmen present class play • 11 new Whitians inducted Monday • Editorial: Where does it end? • Focus: Rick Dougherty • Spotlight: Sue Bower • Erma and Ernie • Sad song sung • Christian Fellowship defined • Fidler on the wax: Yes • Letters to the editor • ProTheatre presents: Marat / Sade • U.C. Arts Festival attracts hundreds • Richard Callner, Philadelphia artist opens five-week exhibit at U.C. • Wismer rip-off • Spring varsity sports schedules • War College panel presents forum at UC • Sig Rho and Zeta Chi provide entertainment • Ursinus baseball challenged; 17 games scheduled for season • Ursinus Bruinettes dunked in basketball, swimming tournamenthttps://digitalcommons.ursinus.edu/weekly/1120/thumbnail.jp

The Ursinus Weekly, April 27, 1972

Ursinus suffers blackout; Transformer explodes • Dr. Helen T. Garrett dies • UC students experience teaching • Dr. Robert M. Veatch to speak at Ursinus College forum • Dr. Allan Lake Rice speaks at conference • Students inducted into Omicron Delta Epsilon • Ursinus seeks $200,000 gift • Lantern elects officers for \u2772-\u2773; Spring issue expected in late May • Editorial: Stop the war • Focus: Jane Siegel • Strike • Faculty portrait: Dr. Gayle Byerly • Guest column: Dr. Allan Rice on war and peace • Letters to the editor: The need of a psychologist; Open letter to security • W.C. rains on our parade • Sing sets record • Bartholomew wins two • Ursinus starts baseball season • Travelin\u27 5\u27s history told • Modern Dance Club: fun for allhttps://digitalcommons.ursinus.edu/weekly/1123/thumbnail.jp

Delayed Seismicity Rate Changes Controlled by Static Stress Transfer

On 15 June 2010, a M_w5.7 earthquake occurred near Ocotillo, California, in the Yuha Desert. This event was the largest aftershock of the 4 April 2010 M_w7.2 El Mayor-Cucapah (EMC) earthquake in this region. The EMC mainshock and subsequent Ocotillo aftershock provide an opportunity to test the Coulomb failure hypothesis (CFS). We explore the spatiotemporal correlation between seismicity rate changes and regions of positive and negative CFS change imparted by the Ocotillo event. Based on simple CFS calculations we divide the Yuha Desert into three subregions, one triggering zone and two stress shadow zones. We find the nominal triggering zone displays immediate triggering, one stress shadowed region experiences immediate quiescence, and the other nominal stress shadow undergoes an immediate rate increase followed by a delayed shutdown. We quantitatively model the spatiotemporal variation of earthquake rates by combining calculations of CFS change with the rate-state earthquake rate formulation of Dieterich (1994), assuming that each subregion contains a mixture of nucleation sources that experienced a CFS change of differing signs. Our modeling reproduces the observations, including the observed delay in the stress shadow effect in the third region following the Ocotillo aftershock. The delayed shadow effect occurs because of intrinsic differences in the amplitude of the rate response to positive and negative stress changes and the time constants for return to background rates for the two populations. We find that rate-state models of time-dependent earthquake rates are in good agreement with the observed rates and thus explain the complex spatiotemporal patterns of seismicity

Delayed Seismicity Rate Changes Controlled by Static Stress Transfer

On 15 June 2010, a M_w5.7 earthquake occurred near Ocotillo, California, in the Yuha Desert. This event was the largest aftershock of the 4 April 2010 M_w7.2 El Mayor-Cucapah (EMC) earthquake in this region. The EMC mainshock and subsequent Ocotillo aftershock provide an opportunity to test the Coulomb failure hypothesis (CFS). We explore the spatiotemporal correlation between seismicity rate changes and regions of positive and negative CFS change imparted by the Ocotillo event. Based on simple CFS calculations we divide the Yuha Desert into three subregions, one triggering zone and two stress shadow zones. We find the nominal triggering zone displays immediate triggering, one stress shadowed region experiences immediate quiescence, and the other nominal stress shadow undergoes an immediate rate increase followed by a delayed shutdown. We quantitatively model the spatiotemporal variation of earthquake rates by combining calculations of CFS change with the rate-state earthquake rate formulation of Dieterich (1994), assuming that each subregion contains a mixture of nucleation sources that experienced a CFS change of differing signs. Our modeling reproduces the observations, including the observed delay in the stress shadow effect in the third region following the Ocotillo aftershock. The delayed shadow effect occurs because of intrinsic differences in the amplitude of the rate response to positive and negative stress changes and the time constants for return to background rates for the two populations. We find that rate-state models of time-dependent earthquake rates are in good agreement with the observed rates and thus explain the complex spatiotemporal patterns of seismicity

Multifunctional T-cell Analyses to Study Response and Progression in Adoptive Cell Transfer Immunotherapy

Adoptive cell transfer (ACT) of genetically engineered T cells expressing cancer-specific T-cell receptors (TCR) is a promising cancer treatment. Here, we investigate the in vivo functional activity and dynamics of the transferred cells by analyzing samples from 3 representative patients with melanoma enrolled in a clinical trial of ACT with TCR transgenic T cells targeted against the melanosomal antigen MART-1. The analyses included evaluating 19 secreted proteins from individual cells from phenotypically defined T-cell subpopulations, as well as the enumeration of T cells with TCR antigen specificity for 36 melanoma antigens. These analyses revealed the coordinated functional dynamics of the adoptively transferred, as well as endogenous, T cells, and the importance of highly functional T cells in dominating the antitumor immune response. This study highlights the need to develop approaches to maintaining antitumor T-cell functionality with the aim of increasing the long-term efficacy of TCR-engineered ACT immunotherapy. Significance: A longitudinal functional study of adoptively transferred TCR–engineered lymphocytes yielded revealing snapshots for understanding the changes of antitumor responses over time in ACT immunotherapy of patients with advanced melanoma

Patients with MEN1 are at an increased risk for venous thromboembolism VTE risk in MEN1

Background: Multiple endocrine neoplasia type 1 (MEN1) is a rare inherited disorder predisposing to the development of multiple functional and non-functional neuroendocrine tumors (NETs). Only uncommon MEN1-associated functional NETs such as glucagonomas (&lt;1%) and ACTH-producing tumors (&lt;5%) are known to be associated with hypercoagulability. It is unknown if patients with MEN1 generally have increased risk of VTE. Methods: We queried a prospective natural history study of germline mutation positive MEN1 patients (n=286) between 1991-2019 for all lifetime events of VTE. Search terms were: DVT, thromb, embol, PE, pulmonary embolism, clot, hematology consult, anticoagulant, coumadin, lovenox, xarelto, warfarin, aspirin, rivaroxaban and apixaban. Incidence rates were calculated accounting for age and sex. Comparison was made to published incidence rates in healthy populations, different types of cancer, and Cushing's syndrome. Results: Thirty-six subjects (median age 45 years, range 16-75) experienced a VTE event, yielding a prevalence rate of 12.9%. The age-sex adjusted incidence rate of VTE is 9.11 per 1,000 patient-years, with a sex-adjusted lifetime incidence rate of 2.81 per 1,000 patient-years. MEN1-associated lifetime incidence rates are ~two-fold higher than the estimated annual incidence rate in the general population and are comparable to known risk in the setting of various types of cancer. Approximately 80% were diagnosed with pancreatic NETs, of which 24% were insulinomas. Fourteen patients (42%) experienced peri-operative VTE events. Conclusions: MEN1 patients have an increased risk of VTE. Further mechanistic investigation and validation from other MEN1 cohorts are needed to confirm the increased prevalence of VTE in MEN1