Geomorphological control on boulder transport and coastal erosion before, during and after an extreme extra-tropical cyclone

Extreme wave events in coastal zones are principal drivers of geomorphic change. Evidence of boulder entrainment and erosional impact during storms is increasing. However, there is currently poor time coupling between pre- and post-storm measurements of coastal boulder deposits. Importantly there are no data reporting shore platform erosion, boulder entrainment and/or boulder transport during storm events – rock coast dynamics during storm events are currently unexplored. Here, we use high-resolution (daily) field data to measure and characterise coastal boulder transport before, during and after the extreme Northeast Atlantic extra-tropical cyclone Johanna in March 2008. Forty-eight limestone fine-medium boulders (n = 46) and coarse cobbles (n = 2) were tracked daily over a 0.1 km2 intertidal area during this multi-day storm. Boulders were repeatedly entrained, transported and deposited, and in some cases broken down (n = 1) or quarried (n = 3), during the most intense days of the storm. Eighty-one percent (n = 39) of boulders were located at both the start and end of the storm. Of these, 92% were entrained where entrainment patterns were closely aligned to wave parameters. These data firmly demonstrate rock coasts are dynamic and vulnerable under storm conditions. No statistically significant relationship was found between boulder size (mass) and net transport distance. Graphical analyses suggest that boulder size limits the maximum longshore transport distance but that for the majority of boulders lying under this threshold, other factors influence transport distance. Paired analysis of 20 similar sized and shaped boulders in different morphogenic zones demonstrates that geomorphological control affects entrainment and transport distance – where net transport distances were up to 39 times less where geomorphological control was greatest. These results have important implications for understanding and for accurately measuring and modelling boulde

Consistent reductions of IIB*/M* theory and de Sitter supergravity

We construct consistent non-linear Kaluza Klein reduction ansatze for a subset of fields arising from the reduction of IIB* and M* theory on dS_5 x H^5 and dS_4 x AdS_7, respectively. These reductions yield four and five-dimensional de Sitter supergravities, albeit with wrong sign kinetic terms. We also demonstrate that the ansatze may be used to lift multi-centered de Sitter black hole solutions to ten and eleven dimensions. The lifted dS_5 black holes correspond to rotating E4-branes of IIB* theory.Comment: 27 pages, late

Do Macroalgal Environments Leave a Geological Signature? Modern Test Case from Kaikoura, New Zealand

Brown, red and green macroalgae in modern temperate marine environments are ecosystem‐forming primary producers on rocky substrates, yet they have a poor preservation potential and few fossil examples are known from the rock record. Macroalgal forests, as carbonate producers, are largely unrecognised within the coolwater carbonate realm even though they host a wide variety of calcareous organisms with good preservational potential. Some species of molluscs, sea urchins and crustaceans only live within the understorey of macroalgal forests. These, and other, calcareous flora and fauna are the key to identification of macroalgae environments in the rock record. Modern macroalgae forests at Kaikoura, New Zealand, exhibit a clear zonation of calcareous components controlled by substrate topography, wave exposure, water depth and light penetration. The prominent live calcareous components include encrusting and foliose coralline red algae, molluscs, bryozoans, echinoderms, calcareous worms, ascidians and crustaceans, as well as sponges and other soft bodied invertebrates. The sediments accumulated beneath and adjacent to the algae at Kaikoura are bioclastic, terrigenous sands and gravels; with bioclasts of coralline algal fragments and rhodoliths, barnacles, molluscs, spirorbids and bryozoans. Although the shallow, wave exposed settings that promote growth of macroalgal forests are limited in areal extent, their contribution via skeletal carbonate may be considerable. In the rock record, terrigenous sands and gravels rich in coralline, barnacle, mollusc, and bryozoan fragments, that occur in association with hard‐substrate unconformities in a cool‐water realm, must be considered as representatives of past macroalgal environments

Human and murine IFIT1 proteins do not restrict infection of negative-sense RNA viruses of the Orthomyxoviridae, Bunyaviridae, and Filoviridae families

UNLABELLED: Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) is a host protein with reported cell-intrinsic antiviral activity against several RNA viruses. The proposed basis for the activity against negative-sense RNA viruses is the binding to exposed 5\u27-triphosphates (5\u27-ppp) on the genome of viral RNA. However, recent studies reported relatively low binding affinities of IFIT1 for 5\u27-ppp RNA, suggesting that IFIT1 may not interact efficiently with this moiety under physiological conditions. To evaluate the ability of IFIT1 to have an impact on negative-sense RNA viruses, we infected Ifit1(-/-) and wild-type control mice and primary cells with four negative-sense RNA viruses (influenza A virus [IAV], La Crosse virus [LACV], Oropouche virus [OROV], and Ebola virus) corresponding to three distinct families. Unexpectedly, a lack of Ifit1 gene expression did not result in increased infection by any of these viruses in cell culture. Analogously, morbidity, mortality, and viral burdens in tissues were identical between Ifit1(-/-) and control mice after infection with IAV, LACV, or OROV. Finally, deletion of the human IFIT1 protein in A549 cells did not affect IAV replication or infection, and reciprocally, ectopic expression of IFIT1 in HEK293T cells did not inhibit IAV infection. To explain the lack of antiviral activity against IAV, we measured the binding affinity of IFIT1 for RNA oligonucleotides resembling the 5\u27 ends of IAV gene segments. The affinity for 5\u27-ppp RNA was approximately 10-fold lower than that for non-2\u27-O-methylated (cap 0) RNA oligonucleotides. Based on this analysis, we conclude that IFIT1 is not a dominant restriction factor against negative-sense RNA viruses. IMPORTANCE: Negative-sense RNA viruses, including influenza virus and Ebola virus, have been responsible for some of the most deadly outbreaks in recent history. The host interferon response and induction of antiviral genes contribute to the control of infections by these viruses. IFIT1 is highly induced after virus infection and reportedly has antiviral activity against several RNA and DNA viruses. However, its role in restricting infection by negative-sense RNA viruses remains unclear. In this study, we evaluated the ability of IFIT1 to inhibit negative-sense RNA virus replication and pathogenesis both in vitro and in vivo. Detailed cell culture and animal studies demonstrated that IFIT1 is not a dominant restriction factor against three different families of negative-sense RNA viruses

The Fruits and Vegetables Industry in Indonesia: Production and Limited Access to Market

Smallholder producers of fruits and vegetables in the Nanggung sub-district of West Java, Indonesia practice a multicropping system of agriculture on less than two acres of land. Agricultural practices in this area are still crude, with little or no inputs such as fertilization or modern irrigation. When water is available, the furrow irrigation system is used at best. Although banana is one of the income-generating crops, farmers grow it in combination with other fruits such as durian, mangosteen, rambutan, jackfruit, and with vegetables such as chili peppers, tomatoes, sweet corn, and green beans under non-intensive management. Although market-survey reports show that the demand for these fruits and vegetables is greater than the supply, the farmers not only have limited access to markets but produce inferior quality and limited quantity (Fonsah 2003). Due to these limitations, this study is aimed at developing new markets, creating new distribution systems and market channels, and seeks ways to improve those already existing.Agribusiness, Crop Production/Industries, Marketing,

P09-15. Selection of higher avidity HLA-restricted T cell responses as a viral adaptation strategy

Loss of immune reactivity due to HIV mutational escape is well described. Data generated from a large population-based study (n>800) suggested that certain CD8 T cell epitopes are created as a result of HIV adaptation and are associated with enhanced viral replication. Here we sought to investigate the HLA-restricted T-cell responses associated with seven such adaptations

An assessment of the strength of knots and splices used as eye terminations in a sailing environment

Research into knots, splices and other methods of forming an eye termination has been limited, despite the fact that they are essential and strongly affect the performance of a rope. The aim of this study was to carry out a comprehensive initial assessment of the breaking strength of eye terminations commonly used in a sailing environment, thereby providing direction for further work in the field. Supports for use in a regular tensile testing machine were specially developed to allow individual testing of each sample and a realistic spread of statistical data to be obtained. Over 180 break tests were carried out on four knots (the bowline, double bowline, figure-of-eight loop and perfection loop) and two splices (three-strand eye splice and braid-on-braid splice). The factors affecting their strength were investigated. A statistical approach to the analysis of the results was adopted. The type of knot was found to have a significant effect on the strength. This same effect was seen in both types of rope construction (three-strand and braid-on-braid). Conclusions were also drawn as to the effect of splice length, eye size, manufacturer and rope diameter on the breaking strength of splices. Areas of development and further investigation were identified

Developing Community Nursing Practice: Promoting Case Management and Skill Enhancement to Support Shifting the Balance of Care

Five inter-related projects were commissioned by NHS Highland to further knowledge and understanding of key issues that can be used to inform particular aspects of care delivery that supports the community nurse review. The five projects reflect some of the core elements that have been identified to maximise nurses’ contributions in community settings (Scottish Executive 2006a). The projects were designed to provide qualitative evidence of the views of community nurses regarding case management and to support the delivery of skills in community nursing practice. Additionally community nurses identified the knowledge and skills required to develop practice tools that would support areas of generalist and specialist practice, specifically around child welfare and long term conditions (heart care). The five projects were: i. Literature review on case management models in Community Nursing. ii. Action research project to support implementation of Case Management Models in community nursing. iii. Literature review on practitioners with special interest. iv. Research to inform development of practitioner tools for child protection and long term conditions (heart care). v. Research to explore skills transition to support Shifting the Balance of Care. This project focused on 3 key initiatives that are influencing community nursing and it was apparent that they all shared common goals and challenges of implementation. For this reason, it was clear that any development in service provision would impact on, and articulate with, other health, social and profession based changes and could not be implemented in isolation from other related developments that underpin shifting the balance of care. Nurses in the studies articulated insightful challenges for shifting the balance of care, and related role developments, but these were, in the majority, followed by offering practical solutions

Convergence Radii for Eigenvalues of Tri--diagonal Matrices

Consider a family of infinite tri--diagonal matrices of the form $L+ zB,$ where the matrix $L$ is diagonal with entries $L_{kk}= k^2,$ and the matrix $B$ is off--diagonal, with nonzero entries $B_{k,{k+1}}=B_{{k+1},k}= k^\alpha, 0 \leq \alpha < 2.$ The spectrum of $L+ zB$ is discrete. For small $|z|$ the $n$-th eigenvalue $E_n (z), E_n (0) = n^2,$ is a well--defined analytic function. Let $R_n$ be the convergence radius of its Taylor's series about $z= 0.$ It is proved that $$ R_n \leq C(\alpha) n^{2-\alpha} \quad \text{if} 0 \leq \alpha <11/6.$