A NOVEL STILL IMAGE MOSAIC ALGORITHM CONSTRUCTION USING FEATURE BASED METHOD

An image mosaic is a method of assembling multiple overlapping images of same scene into a larger one. The output of image mosaic will be the union of two input images. In this paper we have to use three step automatic image mosaic method. The first step is taking two input images and finding out the corners in both the images, second step is finding its matched corner and third step is its blending and we get final output mosaic. The experimental results show the proposed algorithm produces an improvement in mosaic accuracy, efficiency and robustness

Pharmacoepidemiological study of potential drug interactions in heart and neurological outpatients

Background: Drug-drug interaction (DDI) is a potential cause of adverse drug reactions. This study estimates the rate and factors associated with potential DDI in cardiac and neurological prescriptions from the out-patient department of various hospitals.Methods: A cross-sectional study was conducted from February to April, 2014 in various outpatients department of different hospitals in Indore. Total 60 prescriptions of cardiac and 60 prescriptions of neuro patients were collected from different hospitals. All the prescriptions were analyzes by various pharmaceutical and medical books, drug interaction checker software, and journals, etc.Results: Prescriptions having moderate drug interactions are more than that of severe and minor interactions and severity of the interaction found moderate in both type of prescriptions. Among cardiac patients 75% are male and 25% are females including all age groups, and in neuro patients, 58.33% are male, and 41.66% are females including all age groups. Types of drug interaction found in prescriptions are as follow, severe interaction (13% in cardiac, 8% in neuro), and moderate interaction (45% in cardiac, 37% in neuro), minor interaction (17% in cardiac, 25% in neuro), interaction not found (25% in cardiac, 30% in neuro patients).Conclusion: The hazards of prescribing many drugs, including side-effects, DDI and difficulties of compliance have long been recognized as particular problems when prescribing. Proper emphasis should be given to drug information center and training of clinical pharmacy across the country, which can play an important role in minimizing DDIs

Diagnosis and management of skeletal fluorosis in current scenario: a case report

Skeletal fluorosis is a rare form of toxic metabolic disease of bone characterised by increased incorporation of fluoride in bone. Skeletal fluorosis generally occurs in endemic regions where there is increased ingestion of fluorine in water and or food over a long period of time. Fluorosis is a spectrum of disease ranging from dental, non-skeletal fluorosis to skeletal fluorosis. The disease is characterised by typical clinical and radiological features that raise the suspicion towards diagnosis of the disease. Radiographic features are characterized by generalised osteosclerosis and later ossification of ligaments, tendons and interosseous membranes. Skeletal fluorosis can be easily confused with other rheumatologic disorders. People exposed to large amounts of fluoride show dental changes much earlier than the skeletal effects. Management of fluorosis generally focuses on symptomatic treatment

RECENT TRENDS IN MANAGEMENT OF KERATOCONJUNCTIVITIS SICCA (DRY EYE DISEASE)

At the air-water interface, the tear film lipid layer (TFLL), a combination of lipids and proteins plays an important role in surface tension of the tear and is necessary for the physiological hydration of the ocular surface and maintenance of ocular homeostasis. Alteration in lacrimal fluid rheology, differences in lipid constitution or down regulation of particular tear proteins are found in maximum types of ocular surface disease including dry eye disease (DED). Dry eye is a disorder of the tear film due to tear deficiency or excessive tear evaporation, which causes damage to the interpalpebral ocular surface and is associated with symptoms of discomfort. It results in changes on the ocular surface epithelia causing reduced tear quantity and surface sensitivity which leads to inflammation reactions. Managing this inflammation is very helpful in dry eye disease patients. In this article we revise the current understanding of tear film properties, ocular surface and review the effectiveness of topically applied tear supplements, thermo sensitive atelocollagen punctal plug, subtrasal ultrasonic transducers, novel liposome based gelling tear formation and insulin based ophthalmic delivery systems which help in restoring the healthy tear film

Development and Validation of UPLC-MS/MS Method for Rapid Simultaneous Determination of Levothyroxine and Liothyronine in Human Serum

A simple ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) method was developed and fully validated to simultaneously determine levothyroxine (LT4) and liothyronine (LT3) in human serum. Sample preparation was done through protein precipitation with acetonitrile. HyPURITY C18 column was selected to achieve rapid separation for LT4 and LT3 within 4 min. Electrospray ionization (ESI) under multiple reaction monitoring (MRM) was used to monitor the ion transitions for LT4 (m/z 777.54→731.52), LT3 (m/z 651.64→ 605.65) and internal standard LT4-D3 (m/z 780.53 →734.19), operating in the positive ion mode. The method was proved to be accurate (82.35% to 113.56%) and precise (0.73% to 8.28%) over concentration range of 50.37 ng/ml – 300.13 ng/ml for LT4 and 0.5 ng/ml – 50.37 ng/ml for LT3. The validated method could be applied for pharmacokinetic study or bioequivalence testing of combination products of LT4 and LT3. Keywords: Levothyroxine; Liothyronine; Ultra Performance Liquid Chromatographic; Mass Spectrometry; Human Seru

Transmission Wheeling Pricing in Embedded Cost Using Modified Amp-Mile and MVA Utility Factor Methods

Transmission wheeling pricing is one of the decisive aspects of present open access electricity market. Various methods are available for transmission; however, no method is proved to diverse operating conditions of power system. These methods are not able to quantify the full recovery of embedded cost. All the variables i.e. remaining charges, used circuit capacity are not counted in the existing methods. This Paper explicates two methods, Modified Amp – Mile method and MVA Utility Factor method, to recover embedded cost. Modified Amp-Mile method is customized form of existing Amp-Mile method. In the MVA Utility Factor method, cost allocation is based on marginal participation (MP). It evaluates the cost, using sensitivity analysis of network power. The proposed methods are tested on an IEEE 6 bus system and further verified on Hadoti region real 37 bus system. All the results are presented in Full Recovery Model (FRM) and Partial Recovery Model (PRM)

Analytical Study of Raktvaha Srotas and Raktavahi Sira w.s.r. to Enucleated Erythrocyte

Dhatus are the constitutional elements of the body having properties of Dhaaran and Poshan and to restore their specific function is the principle of Ayurveda. Rakta Dhatu is the base of living being as it maintains life. To fulfill this purpose, Rakta circulates to each n every cell of body through its channel (Raktavaha Srotas). Acharya Charaka described only two moola of this Srotas viz Yakrit and Pleeha. Liver and spleen is the productive site and Raktavahi Dhamni (By Sushruta) are the conductive site to be consider as Raktavaha Srotomoola as Srotas includes Ashaya, Dhamni, Rasayni, Sira etc. Raktavahi Sira are the conductive sites of Rakta Dhatu i.e., the vessels loaded with newly formed blood cells. Life is the chief function of Rakta Dhatu as it conducts Prana to every Dhatu of body. So Rakta Dhatu should be considered in treatment of Pranakshaya, Sammoha (weakness, malaise, faint etc). Dhatu Kshaya and Vriddhi of other Dhatu are dependent on Rakta Dhatu. Snayu and Sira are formed during the formation of Rakta Dhatu as they are the Upadhatu of it. So, in the vitiation of them (diseases of Snayu & Sira), Rakta Dhatu should be considered in treatment plan. In Raktajvikaar like Raktakshayaja (Anemia, thrombocytopenia, leukopenia, Polycythemia, leukocytosis, thrombosis), Rakta should be primarily considered and for that Yakrit and Pleeha should also be considerable in management of above

Phytochemical Screening and Evaluation of Antiulcer Activity of Hydroalcoholic Extract of Lilium Candidum Flowers

Peptic disorders like gastro esophageal reflux disease, gastritis, peptic ulcer, duodenal ulcer etc., are the common in today’s life style. This may be due to stressful life style or improper balance diet. The pathology behind these disorders may be discrepancy between offensive and defensive mechanisms either by excess secretion of acid and pepsin or diminished ability of the gastro-duodenal mucosal barrier to protect against stomach acid-pepsin secretion. Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of the most commonly used medicines and proven to be effective for certain disorders. Some people use NSAIDs on daily basis for preventive purpose. But a variety of severe side effects can be induced by NSAIDs. Studies have shown that edible natural ingredients exhibit preventive benefit of gastric ulcer. Therefore present study was designed to evaluate antiulcer activity of hydroalcoholic extract of Lilium candidum flowers in rats. Qualitative analysis of various phytochemical constituents and quantitative analysis of total phenolics and flavonoids were determined by the well-known test protocol available in the literature. The in vivo anti-ulcer activity of hydroalcoholic extract was assessed against Aspirin-induced gastric ulcer in rats. Depending on the model, outcome measures were pH of gastric fluid and ulcer index as well as percent inhibition of ulcer index. Preliminary phytochemical screening revealed the presence of flavonoids, carbohydrates, saponins, polyphenols and amino acids. The total phenolics content of L. candidum extract was (1.039mg/100mg), followed by flavonoids (0.941mg/100mg) respectively. Further hydroalcoholic extract of 100 and 200mg/kg/p.o significantly (p˂0.01) reduced the gastric pH, ulcer index in aspirin induced ulcer models in rats. The findings of this study confirmed that L. candidum extract has anti-ulcer pharmacologic activity due to one or more of the secondary metabolites present in it. Therefore, this study validates its anti-ulcer use in Indian folk medicine. Further investigations on isolation of specific phytochemicals and elucidating mechanisms of action are needed. Keywords: Lilium candidum, Phytochemical constituents, Antiulcer, Non-steroidal anti-inflammatory drugs, Aspirin-induced gastric ulcer

Immunomodulatory potential of a bioactive fraction from the leaves of Phyllostachys bambusoides (Bamboo) in Balb/c mice

In order to evaluate the role of ethyl acetate fraction (PB-EtAC) obtained from the Phyllostachys bambusoides leaves in the modulation of immune responses, detailed studies were carried out using a panel of in vivo assays. Oral administration of PB-EtAC (50–200 mg/Kg) stimulated the IgM and IgG titre expressed in the form of haemagglutination antibody (HA) titre. Further, it elicited a dose related increase in the delayed type hypersensitivity reaction (DTH) after 24 and 48 h in BALB/c mice. Besides augmenting the humoral and cell mediated immune response, the concentration of cytokines (IFN-γ, IL-2, and IL-4) in serum with respect to T cell interactions also increased significantly. It also induced macrophage phagocytosis, and nitric oxide (NO) production which resulted in a high degree of protection against Candida albicans and carbon clearance. Moreover, the enhancement in CD4 and CD8 cell populations as revealed by flow cytometry. Taken together this in vivo and ex vivo preclinical data, our results suggested that PB-EtAC acts as an effective immunostimulator eliciting both Th1 and Th2 immune responses. We are reporting first time the immunostimulatory potential of P. bambusoides and it might be regarded as a biological response modifier