2,122 research outputs found
Excitability changes induced in rat neo-cortical neurons by the selective blockade of a low KM, Ca2+/calmodulin-independent cAMP-phosphodiesterase.
Action for the eleven dimensional multiple M-wave system
We present the covariant supersymmetric and kappa-symmetric action for a
system of N nearly coincident M-waves (multiple M0-brane system) in flat eleven
dimensional superspace.Comment: 4+ pages, RevTeX4, no figures. V2: misprints corrected, discussion
extended, references added, LaTeX, 10 pages. V3: misprints corrected. V4,
extended version, 1+13 pages, to appear in JHE
Experimental Validation of Contact Dynamics for In-Hand Manipulation
This paper evaluates state-of-the-art contact models at predicting the
motions and forces involved in simple in-hand robotic manipulations. In
particular it focuses on three primitive actions --linear sliding, pivoting,
and rolling-- that involve contacts between a gripper, a rigid object, and
their environment. The evaluation is done through thousands of controlled
experiments designed to capture the motion of object and gripper, and all
contact forces and torques at 250Hz. We demonstrate that a contact modeling
approach based on Coulomb's friction law and maximum energy principle is
effective at reasoning about interaction to first order, but limited for making
accurate predictions. We attribute the major limitations to 1) the
non-uniqueness of force resolution inherent to grasps with multiple hard
contacts of complex geometries, 2) unmodeled dynamics due to contact
compliance, and 3) unmodeled geometries dueto manufacturing defects.Comment: International Symposium on Experimental Robotics, ISER 2016, Tokyo,
Japa
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Predictive impact of rare genomic copy number variations in siblings of individuals with autism spectrum disorders.
Identification of genetic biomarkers associated with autism spectrum disorders (ASDs) could improve recurrence prediction for families with a child with ASD. Here, we describe clinical microarray findings for 253 longitudinally phenotyped ASD families from the Baby Siblings Research Consortium (BSRC), encompassing 288 infant siblings. By age 3, 103 siblings (35.8%) were diagnosed with ASD and 54 (18.8%) were developing atypically. Thirteen siblings have copy number variants (CNVs) involving ASD-relevant genes: 6 with ASD, 5 atypically developing, and 2 typically developing. Within these families, an ASD-related CNV in a sibling has a positive predictive value (PPV) for ASD or atypical development of 0.83; the Simons Simplex Collection of ASD families shows similar PPVs. Polygenic risk analyses suggest that common genetic variants may also contribute to ASD. CNV findings would have been pre-symptomatically predictive of ASD or atypical development in 11 (7%) of the 157 BSRC siblings who were eventually diagnosed clinically
Rigidity of SU(2,2|2)-symmetric solutions in Type IIB
We investigate the existence of half-BPS solutions in Type IIB supergravity
which are invariant under the superalgebra SU(2,2|2) realized on either AdS_5 x
S^2 x S^1 or AdS_5 x S^3 warped over a Riemann surface \Sigma with boundary. We
prove that, in both cases, the only solution is AdS_5 x S^5 itself. We argue
that this result provides evidence for the non-existence of fully back-reacted
intersecting D3/D7 branes with either AdS_5 x S^2 x S^1 x \Sigma or AdS_5 x S^3
x \Sigma near-horizon limits.Comment: 55 page
Local biases drive, but do not determine, the perception of illusory trajectories
When a dot moves horizontally across a set of tilted lines of alternating orientations, the dot appears to be moving up and down along its trajectory. This perceptual phenomenon, known as the slalom illusion, reveals a mismatch between the veridical motion signals and the subjective percept of the motion trajectory, which has not been comprehensively explained. In the present study, we investigated the empirical boundaries of the slalom illusion using psychophysical methods. The phenomenon was found to occur both under conditions of smooth pursuit eye movements and constant fixation, and to be consistently amplified by intermittently occluding the dot trajectory. When the motion direction of the dot was not constant, however, the stimulus display did not elicit the expected illusory percept. These findings confirm that a local bias towards perpendicularity at the intersection points between the dot trajectory and the tilted lines cause the illusion, but also highlight that higher-level cortical processes are involved in interpreting and amplifying the biased local motion signals into a global illusion of trajectory perception
A systematic review of strategies to recruit and retain primary care doctors
Background There is a workforce crisis in primary care. Previous research has looked at the reasons underlying recruitment and retention problems, but little research has looked at what works to improve recruitment and retention. The aim of this systematic review is to evaluate interventions and strategies used to recruit and retain primary care doctors internationally. Methods A systematic review was undertaken. MEDLINE, EMBASE, CENTRAL and grey literature were searched from inception to January 2015.Articles assessing interventions aimed at recruiting or retaining doctors in high income countries, applicable to primary care doctors were included. No restrictions on language or year of publication. The first author screened all titles and abstracts and a second author screened 20%. Data extraction was carried out by one author and checked by a second. Meta-analysis was not possible due to heterogeneity. Results 51 studies assessing 42 interventions were retrieved. Interventions were categorised into thirteen groups: financial incentives (n=11), recruiting rural students (n=6), international recruitment (n=4), rural or primary care focused undergraduate placements (n=3), rural or underserved postgraduate training (n=3), well-being or peer support initiatives (n=3), marketing (n=2), mixed interventions (n=5), support for professional development or research (n=5), retainer schemes (n=4), re-entry schemes (n=1), specialised recruiters or case managers (n=2) and delayed partnerships (n=2). Studies were of low methodological quality with no RCTs and only 15 studies with a comparison group. Weak evidence supported the use of postgraduate placements in underserved areas, undergraduate rural placements and recruiting students to medical school from rural areas. There was mixed evidence about financial incentives. A marketing campaign was associated with lower recruitment. Conclusions This is the first systematic review of interventions to improve recruitment and retention of primary care doctors. Although the evidence base for recruiting and care doctors is weak and more high quality research is needed, this review found evidence to support undergraduate and postgraduate placements in underserved areas, and selective recruitment of medical students. Other initiatives covered may have potential to improve recruitment and retention of primary care practitioners, but their effectiveness has not been established
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Improved Upper Limit on the Neutrino Mass from a Direct Kinematic Method by KATRIN.
We report on the neutrino mass measurement result from the first four-week science run of the Karlsruhe Tritium Neutrino experiment KATRIN in spring 2019. Beta-decay electrons from a high-purity gaseous molecular tritium source are energy analyzed by a high-resolution MAC-E filter. A fit of the integrated electron spectrum over a narrow interval around the kinematic end point at 18.57 keV gives an effective neutrino mass square value of (-1.0_{-1.1}^{+0.9}) eV^{2}. From this, we derive an upper limit of 1.1 eV (90% confidence level) on the absolute mass scale of neutrinos. This value coincides with the KATRIN sensitivity. It improves upon previous mass limits from kinematic measurements by almost a factor of 2 and provides model-independent input to cosmological studies of structure formation
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