1,371 research outputs found
Application of the operator product expansion to the short distance behavior of nuclear potentials
We investigate the short distance behavior of nucleon-nucleon (NN) potentials
defined through Bethe-Salpeter wave functions, by perturbatively calculating
anomalous dimensions of 6-quark operators in QCD. Thanks to the asymptotic
freedom of QCD, 1-loop computations give certain exact results for the
potentials in the zero distance limit. In particular the functional form of the
S-state central NN potential at short distance is predicted to be a little
weaker than . On the other hand, due to the intriguing character of the
anomalous dimension spectrum, perturbative considerations alone can not
determine whether this potential is repulsive or attractive at short distances.
A crude estimation suggests that the force at short distance is repulsive, as
found numerically in lattice QCD. A similar behavior is found for the tensor
potential.Comment: 40 pages, no figure
Evaluation of the use of bioelectrical impedance analysis in assessing the hydration and fluid balance of infants with bronchiolitis requiring intensive care
Kahler Independence of the G2-MSSM
The G2-MSSM is a model of particle physics coupled to moduli fields with
interesting phenomenology both for colliders and astrophysical experiments. In
this paper we consider a more general model - whose moduli Kahler potential is
a completely arbitrary G2-holonomy Kahler potential and whose matter Kahler
potential is also more general. We prove that the vacuum structure and spectrum
of BSM particles is largely unchanged in this much more general class of
theories. In particular, gaugino masses are still supressed relative to the
gravitino mass and moduli masses. We also consider the effects of higher order
corrections to the matter Kahler potential and find a connection between the
nature of the LSP and flavor effects.Comment: Final version, matches the version published in JHE
The Two Faces of Anomaly Mediation
Anomaly mediation is a ubiquitous source of supersymmetry (SUSY) breaking
which appears in almost every theory of supergravity. In this paper, we show
that anomaly mediation really consists of two physically distinct phenomena,
which we dub "gravitino mediation" and "Kahler mediation". Gravitino mediation
arises from minimally uplifting SUSY anti-de Sitter (AdS) space to Minkowski
space, generating soft masses proportional to the gravitino mass. Kahler
mediation arises when visible sector fields have linear couplings to SUSY
breaking in the Kahler potential, generating soft masses proportional to beta
function coefficients. In the literature, these two phenomena are lumped
together under the name "anomaly mediation", but here we demonstrate that they
can be physically disentangled by measuring associated couplings to the
goldstino. In particular, we use the example of gaugino soft masses to show
that gravitino mediation generates soft masses without corresponding goldstino
couplings. This result naively violates the goldstino equivalence theorem but
is in fact necessary for supercurrent conservation in AdS space. Since
gravitino mediation persists even when the visible sector is sequestered from
SUSY breaking, we can use the absence of goldstino couplings as an unambiguous
definition of sequestering.Comment: 21 pages, 1 table; v2, references added, extended discussion in
introduction and appendix; v3, JHEP versio
Ecological succession of a Jurassic shallow-water ichthyosaur fall.
After the discovery of whale fall communities in modern oceans, it has been hypothesized that during the Mesozoic the carcasses of marine reptiles created similar habitats supporting long-lived and specialized animal communities. Here, we report a fully documented ichthyosaur fall community, from a Late Jurassic shelf setting, and reconstruct the ecological succession of its micro- and macrofauna. The early 'mobile-scavenger' and 'enrichment-opportunist' stages were not succeeded by a 'sulphophilic stage' characterized by chemosynthetic molluscs, but instead the bones were colonized by microbial mats that attracted echinoids and other mat-grazing invertebrates. Abundant cemented suspension feeders indicate a well-developed 'reef stage' with prolonged exposure and colonization of the bones prior to final burial, unlike in modern whale falls where organisms such as the ubiquitous bone-eating worm Osedax rapidly destroy the skeleton. Shallow-water ichthyosaur falls thus fulfilled similar ecological roles to shallow whale falls, and did not support specialized chemosynthetic communities
Condensate cosmology in O'Raifeartaigh models
Flat directions charged under an R-symmetry are a generic feature of
O'Raifeartaigh models. Non-topological solitons associated with this symmetry,
R-balls, are likely to form through the fragmentation of a condensate, itself
created by soft terms induced during inflation. In gravity mediated SUSY
breaking R-balls decay to gravitinos, reheating the universe. For gauge
mediation R-balls can provide a good dark matter candidate. Alternatively they
can decay, either reheating or cooling the universe. Conserved R-symmetry
permits decay to gravitinos or gauginos, whereas spontaneously broken
R-symmetry results in decay to visible sector gauge bosons.Comment: 29 pages, 5 figures. Comments and references added, accepted for
publication in JHE
Listeriolysin O Is Strongly Immunogenic Independently of Its Cytotoxic Activity
The presentation of microbial protein antigens by Major Histocompatibility Complex (MHC) molecules is essential for the development of acquired immunity to infections. However, most biochemical studies of antigen processing and presentation deal with a few relatively inert non-microbial model antigens. The bacterial pore-forming toxin listeriolysin O (LLO) is paradoxical in that it is cytotoxic at nanomolar concentrations as well as being the source of dominant CD4 and CD8 T cell epitopes following infection with Listeria monocytogenes. Here, we examined the relationship of LLO toxicity to its antigenicity and immunogenicity. LLO offered to antigen presenting cells (APC) as a soluble protein, was presented to CD4 T cells at picomolar to femtomolar concentrations- doses 3000â7000-fold lower than free peptide. This presentation required a dose of LLO below the cytotoxic level. Mutations of two key tryptophan residues reduced LLO toxicity by 10â100-fold but had no effect on its presentation to CD4 T cells. Thus there was a clear dissociation between the cytotoxic properties of LLO and its very high antigenicity. Presentation of LLO to CD8 T cells was not as robust as that seen in CD4 T cells, but still occurred in the nanomolar range. APC rapidly bound and internalized LLO, then disrupted endosomal compartments within 4 hours of treatment, allowing endosomal contents to access the cytosol. LLO was also immunogenic after in vivo administration into mice. Our results demonstrate the strength of LLO as an immunogen to both CD4 and CD8 T cells
Respiratory support by neurally adjusted ventilatory assist (NAVA) in severe RSV-related bronchiolitis: a case series report
<p>Abstract</p> <p>Background</p> <p>Neurally adjusted ventilatory assist (NAVA) is a new mode of mechanical ventilation controlled by diaphragmatic electrical signals. The electrical signals allow synchronization of ventilation to spontaneous breathing efforts of a child, as well as permitting pressure assistance proportional to the electrical signal. NAVA provides equally fine synchronization of respiratory support and pressure assistance varying with the needs of the child. NAVA has mainly been studied in children who underwent cardiac surgery during the period of weaning from a respirator.</p> <p>Case presentation</p> <p>We report here a series of 3 children (1 month, 3 years, and 28 days old) with severe respiratory distress due to RSV-related bronchiolitis requiring invasive mechanical ventilation with a high level of oxygen (FiO<sub>2 </sub>â„50%) for whom NAVA facilitated respiratory support. One of these children had diagnosis criteria for acute lung injury, another for acute respiratory distress syndrome.</p> <p>Establishment of NAVA provided synchronization of mechanical ventilatory support with the breathing efforts of the children. Respiratory rate and inspiratory pressure became extremely variable, varying at each cycle, while children were breathing easily and smoothly. All three children demonstrated less oxygen requirements after introducing NAVA (57 ± 6% to 42 ± 18%). This improvement was observed while peak airway pressure decreased (28 ± 3 to 15 ± 5 cm H<sub>2</sub>O). In one child, NAVA facilitated the management of acute respiratory distress syndrome with extensive subcutaneous emphysema.</p> <p>Conclusions</p> <p>Our findings highlight the feasibility and benefit of NAVA in children with severe RSV-related bronchiolitis. NAVA provides a less aggressive ventilation requiring lower inspiratory pressures with good results for oxygenation and more comfort for the children.</p
A positioning pillow to improve lumbar puncture success rate in paediatric haematology-oncology patients: a randomized controlled trial
<p>Abstract</p> <p>Background</p> <p>Lumbar punctures (LPs) are common in children with cancer. Although pain management during the lumbar puncture has been well standardized, dealing with stress and anxiety is not well addressed yet. Our objective was to evaluate the potential improvement of the LP success rate using a positioning pillow, to ensure maximum lumbar flexion, and allow paravertebral muscles to relax, in children who are awake, with either conscious sedation or no sedation.</p> <p>Methods</p> <p>Children aged 2â18 years undergoing LP were randomly assigned to a positioning pillow or no intervention. The primary outcome was the rate of success, i.e. achieving the LP (sampling or injection) at the first attempt, without bleeding (RBC < 50/mm<sup>3</sup>). The secondary outcomes included: the child's pain, assessed by a self-administered visual analogical scales (VAS) for children over 6 years of age; the parents' and caregivers' perception of the child's pain; the satisfaction of the children, the parents, the caregivers and the physician. The child's cooperation and the occurrence of post-LP syndrome were also evaluated.</p> <p>Results</p> <p>124 children (62 in each group) were included. The LP pillow tended to increase the success rate of LPs (67% vs. 57%, p = 0.23), and decreased the post-LP syndromes (15% vs. 24%, p = 0.17) but the differences were not statistically significant. In children over 6-year of age (n = 72), the rate of success was significantly higher in the pillow group (58.5% vs. 41.5%, p = 0.031), with a tendency to feel less pain (median VAS 25 vs. 15 mm, p = 0.39) and being more satisfied (84.4% vs. 75.0%, p = 0.34).</p> <p>Conclusion</p> <p>Overall results do not demonstrate a benefit in using this pillow for lumbar punctures. This study results also suggest a benefit in the sub group of children over 6-year of age; this result needs confirmation.</p> <p>Trial Registration</p> <p>The trial was registered with Clinical Trials.gov (number NCT00775112).</p
Inherent Dynamics of the Acid-Sensing Ion Channel 1 Correlates with the Gating Mechanism
A combination of computational and experimental approaches reveals the dynamics of ASIC1 gating, involving a deformation of the channel that triggers âtwist-to-openâ motions of the channel pore
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