9 research outputs found
Requisitos mĂnimos para o laudo de anatomia patolĂłgica em cĂąncer de pulmĂŁo: justificativas na patogĂȘnese
- Author
- ALECSANDER GUILLAMON PEREIRA DA SILVA
- ALEXANDRE MUXFELDT AB'SABER
- Anelli A
- Antonangelo L
- Antonangelo L
- Bagashawe KD
- Barbuto JAM
- Battlehner CN
- Bearhs OH
- Bernardi FDC
- Bernardi FDC
- Cannon-Albright LA
- Capelozzi VL
- Capelozzi VL
- Caporrino C
- Carey FA
- Carvalho HA
- Clements Jr. NC
- Coombes RC
- CĂLIA PETROSSI GALLO
- Delmonte Capelozzi V
- Delmonte Capelozzi V
- Delmonte Capelozzi V
- Demarchi MF
- Demarchi MF
- FERNANDO BRANDĂO
- Gail MH
- Gatter KC
- Gazdar AF
- Ginsberg RJ
- Graham EA
- Graziano SL
- Gross JL
- Hinson KFW
- Husgafvel-Pursiainen K
- Johnson DH
- Jorgensen L
- Kern JA
- Kreyberg L
- Li ZH
- Macchiarini P
- Mao L
- Morkve O
- Mountain CF
- Myamoto H
- Naruke T
- Ookawa K
- Rodrigues OR
- Rogli VL
- Rosai J
- Schwartz MK
- Seregni E
- Sun J
- Takagaki TY
- Tungehar MF
- VERA LUIZA CAPELOZZI
- Younes RN
- Zhang Y
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Usefulness of argyrophilic nucleolar organizer regions in detection of lung cells alterations after benzo[a]pyrene instillation
- Author
- Abe S
- Agen B
- Alves APNN
- Antonangelo L
- Baldomero Antonio Kato da Silva
- Brundage MD
- Capelozzi VL
- Chern JH
- Daniel Martins Pereira
- Duarte RLM
- Fisseler-Eckhoff A
- Forgacs E
- Harrigan JA
- Iandara Schettert Silva
- Kaneko S
- Kong LY
- Lenox RJ
- Massion PP
- Paulo de Tarso Camillo de Carvalho
- Ricardo Dutra Aydos
- Rocher AE
- Rodrigues OR
- Silva LFG
- Wong DTW
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2006
- Field of study
Improving conversion yield of fermentable sugars into fuel ethanol in 1st generation yeast-based production processes
- Author
- Andreas K Gombert
- Anjos
- Antonangelo
- Antonius JA van Maris
- Argueso
- Avalos
- Babrzadeh
- Basso
- Basso
- Basso
- Benisch
- Björkqvist
- Brown
- Carvalho-Netto
- Caspeta
- de Kok
- Della-Bianca
- Della-Bianca
- Della-Bianca
- DiCarlo
- Dmytruk
- Galafassi
- Galeote
- Greetham
- Guadalupe-Medina
- Hasunuma
- Henderson
- Hubmann
- Hubmann
- Hubmann
- Inaba
- Jain
- Kuijpers
- Le Borgne
- Leite
- Lu
- Maiorella
- Meneghin
- Navas
- Nissen
- Overkamp
- Pagliardini
- Peng
- Puligundla
- Ramos
- Reis
- Semkiv
- Shahsavarani
- Swinnen
- van Dijken
- Wallace-Salinas
- Zelle
- Zheng
- Zheng
- Zheng
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Biochar from sawmill residues: characterization and evaluation for its potential use in the horticultural growing media
- Author
- A MĂ©ndez
- A Nieto
- A van der Wal
- AJ Margenot
- B Bhatta
- BB Kaudal
- BK Hoover
- C Steiner
- CL Webber
- D Rathnayake
- D Rathnayake
- D Rathnayake
- F Fornes
- F Ronsse
- GE Barrett
- J Lehmann
- J Mumme
- JA Antonangelo
- JE Altland
- K Crombie
- K Weber
- L Huang
- L Leng
- M Prasad
- ME Torbaghan
- MR Nemati
- MS Reza
- N Rogovska
- NT Girkin
- O MaĆĄek
- O Munzuroglu
- P Dalias
- P Wu
- R Keskinen
- RA Robertson
- RK Dumroese
- S Carter
- SE Page
- SF Vaughn
- SV Vassilev
- V Gravel
- V LĂ©vesque
- W Buss
- W Buss
- Y Tian
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Inoculation of Azospirillum brasilense associated with silicon as a liming source to improve nitrogen fertilization in wheat crops
- Author
- A Artyszak
- A Majeed
- AOS Dorneles
- B CassĂĄn
- BS Tubana
- C Forni
- C Ju
- CAC Crusciol
- CAC Crusciol
- CH Linden
- CJ Alves
- D Coskun
- D Xu
- D Xu
- DM Zeffa
- DM Zeffa
- E Epstein
- E McLarnon
- F Guntzer
- F Torabi
- FS Galindo
- FS Galindo
- FS Galindo
- FS Galindo
- FS Galindo
- FS Galindo
- Fukami
- G Agegnehu
- GP Mateus
- GSA Castro
- GY Mahama
- H Etesami
- H Etesami
- H Gong
- HF Bakhat
- I Vega
- J Carlsson
- J Fukami
- J Fukami
- J Fukami
- J Heckman
- J Mon
- J Schaller
- JA Antonangelo
- JC Zadoks
- JD Munareto
- JF Ma
- JF Ma
- JK Ladha
- JM Bremner
- K Fujii
- K Tamai
- KC Detmann
- KP Woli
- KR Baral
- L Lassaletta
- L Rezakhani
- L Xia
- LC Pereira
- LP Salvo
- M Adrees
- M Amin
- M Araujo
- M Hungria
- M Isa
- MP Quatrin
- MR Martins
- MS Camargo
- MS Zaheer
- MVM Sarto
- OS Walsh
- P Vejan
- PH Korndörfer
- PHMP Nunes
- R Hajiboland
- RC Leite
- RH Moll
- RJ Haynes
- S Ahmed
- S Donn
- S Mahmood
- S Mandal
- S Neu
- SM RamĂrez-Olvera
- SS Conceição
- SS Shapiro
- TF Morris
- Y Bashan
- Y Pii
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Long-term lime and phosphogypsum broadcast affects phosphorus cycling in a tropical Oxisol cultivated with soybean under no-till
- Author
- A Mehlich
- A Zhang
- AC Edwards
- ACA Carmeis Filho
- B van Raij
- B van Raij
- B van Raij
- BJ Cade-Menun
- BJ Cade-Menun
- BJ Cade-Menun
- BL Henderson
- BL Turner
- BL Turner
- C Giaveno
- C Giaveno
- CH Kurihara
- CHM Costa
- D Abdi
- D Neina
- DL Heanes
- ED Roy
- EF Caires
- EF Caires
- EF Caires
- EJ Kamprath
- F Eivazi
- F GĂ©rard
- FCB Zambrosi
- GW Gee
- H Andersson
- H Cantarella
- H Omidi
- HA Souza
- HAW Joris
- HE Shoemaker
- IH Rorison
- IR Silva
- J Liu
- J Murphy
- J Zhao
- JA Antonangelo
- JC Tarafdar
- JS Geelhoed
- K Moedritzer
- L Celi
- L Condron
- L Narro
- LM Condron
- M Campos
- M Khanna
- MA Tabatabai
- MAG Hinkle
- MC Rowley
- MF Qayyum
- MF Reeve
- MI Makarov
- NE Smeck
- NK Fageria
- NK Fageria
- NK Fageria
- NS Bolan
- NZ Lupwayi
- PM Bertsch
- PNC Murphy
- R Fuentes-Llanillo
- RJ Haynes
- RL Fox
- RR Bender
- RR Simard
- RW Mcdowell
- RW Mcdowell
- S von Tucher
- SC Blum
- SH Sirois
- Soil Survey Staff
- T Tiecher
- TI McLaren
- TM Inagaki
- TS George
- USPEA
- V Acosta-MartĂnez
- V Acosta-MartĂnez
- WA Dick
- X Yang
- ZF Lund
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Biochar characterization of invasive Pennisetum purpureum grass: effect of pyrolysis temperature
- Author
- A Afif
- A Ahmed
- A Ahmed
- A Budai
- A Demirbas
- A MĂ©ndez
- A-NA El-Hendawy
- AB Boose
- AB Fuertes
- ACS Talari
- B Chen
- B Glaser
- C Huang
- C Popescu
- C Sheng
- C Williams
- CA Mullen
- D Angın
- D Kumar
- D Menegol
- D Pimentel
- D Ăzçimen
- DH Moon
- DR Gordon
- F Hao
- FA Smith
- H Yang
- I Gelfand
- I Mohammed
- J Lehmann
- J Lehmann
- J Liu
- J Meng
- J Zhang
- J-H Yuan
- JA Antonangelo
- JF Parr
- JS Cha
- K Raveendran
- K Raveendran
- K Weber
- KA Smith
- KB Cantrell
- KH Kim
- KN Palansooriya
- L Johannes
- LJ Konwar
- M Ahmad
- M Ahmad
- M Alhinai
- M Becidan
- M Brebu
- M Gray
- M Irfan
- M Traoré
- M Uchimiya
- M Waqas
- M Weih
- MA Hossain
- MG GrĂžnli
- MH Duku
- MI Al-Wabel
- MI Jahirul
- MI Schnitzer
- MJ Antal
- MK Hossain
- MS Reza
- MS Reza
- N Akhtar
- N Liu
- N Radenahmad
- O Das
- P Mohanty
- P Wu
- Q Huang
- Q Zhang
- R Azargohar
- R Saikia
- S Afroze
- S Afroze
- S Afroze
- S Bikbulatova
- S Hidayat
- S Naik
- S Nanda
- S Oladele
- S Tanaka
- S Tayibi
- S Thangalazhy-Gopakumar
- SD Ferreira
- SD Ferreira
- SN Islam
- TL Grey
- V Basso
- V Kumar
- V Oja
- W Chen
- W Chen
- W Song
- W-J Liu
- WJ de Lange
- X Colom
- X Ma
- Y Chen
- Y Chun
- Y Yao
- Y Zhang
- Z Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Body fluid analysis: Clinical utility and applicability of published studies to guide interpretation of todayâs laboratory testing in serous fluids
- Author
- Alatas F
- Albillos A
- Alexandrakis MG
- Alicia Algeciras-Schimnich
- Antonangelo L
- Atalay F
- Bansal S
- Ben-Horin S
- Ben-Horin S
- Bielsa S
- Bou-Khalil PK
- Boyer TD
- Branca P
- Buccheri G
- Burgess LJ
- Burgess LJ
- Burgess LJ
- Caselmann WH
- Castaldo G
- Chandler TM
- Chen SJ
- Cheng DS
- Colloredo Mels G
- Cooper GR
- Costa M
- Darci R. Block
- Darwin P
- Das AK
- Das BB
- Deeks JJ
- Doumas BT
- Duffy MJ
- Elis A
- Engel H
- Fahim A
- Garcia-Pachon E
- Garcia-Pachon E
- Garrison RN
- Gaspar MJ
- Gazquez I
- Gerbes AL
- Gerbes AL
- Gil Suay V
- Gillery P
- Gitlin N
- Gold P
- Gold P
- Gonlugur U
- Gulyas M
- Gupta R
- Hackbarth JS
- Hamm H
- Heffner JE
- Hooper C
- Hou W
- Hurtado C
- Jenkinson F
- Joseph J
- Joseph J
- Joseph J
- Jung M
- Jungst D
- Jungst D
- Kajani MA
- Kalayci AG
- Kaleta EJ
- Karatolios K
- Khandwalla HE
- Kindig JR
- Korczynski P
- Lee CM
- Lee IK
- Lee JH
- Leers MP
- Lestuzzi C
- Li CS
- Liang QL
- Light RW
- Light RW
- Light RW
- Light RW
- Maisch B
- Maisch B
- Mangaraj M
- Maskell NA
- McGrath EE
- Meisel S
- Metintas M
- Miedouge M
- Molina R
- Mortensen PB
- Noppen M
- Perkins GL
- Poe RH
- Porcel JM
- Porcel JM
- Porcel JM
- Potts DE
- Potts DE
- Prieto M
- Rahman NM
- Rai RR
- Rana SV
- Rector WG
- Romero S
- Romero-Candeira S
- Roth BJ
- Runyon
- Runyon BA
- Runyon BA
- Runyon BA
- Runyon BA
- Runyon BA
- Runyon BA
- Sangsayunh P
- Sari R
- Sarodia BD
- Scemama-Clergue J
- Schoenicke G
- Seth AK
- Sheer TA
- Shitrit D
- Spencer K
- Steinberg W
- Sthaneshwar P
- Suzuki H
- Szturmowicz M
- Szturmowicz M
- Tarn AC
- Tatsuta M
- Tomb J
- Torresini RJ
- Toumbis M
- Tuzun Y
- Tuzun Y
- Ustun H
- Uzun K
- Valdes L
- Viljoen A
- Villamil FG
- Villena V
- Villena V
- Vives M
- Wagner IC
- Wilson JA
- Wong CL
- Wroblewski F
- Yang CY
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Ezetimibe added to statin therapy after acute coronary syndromes
- Author
- Aagnes I
- Aambakk MB
- Aase O
- Aaser E
- Abdel-Latief A
- Abell T
- Aboufakher R
- Abramson B
- Abrantes J
- Achilli A
- Adams A
- Adams K
- Adamus J
- Addington J
- Adgey A
- Adjei A
- Agarwal J
- Aggarwal A
- Aggarwal K
- Aggarwal R
- Agocha A
- Agraou B
- Aguirre O
- Ahmed A
- Ahmed O
- Ahsan A
- Airaksinen J
- Airoldi F
- Aji J
- Akkad H
- Akubzanova E
- Al-Ani R
- Al-Jumaily J
- Alameda J
- Albirini A
- Albuquerque A
- Albuquerque D
- Alcasena S
- Alexander J
- Alfonso F
- Ali MI
- Alings MA
- Allall O
- Allen J
- Allen RP
- Allred S
- Almeira AS
- Alonso L
- Alsagheer S
- Alshaher M
- Altschuller A
- Alvarez J
- Alvarez J
- Alvarez Y
- Alves A
- Amidon T
- Amos M
- Anaszewicz M
- Andersen M
- Andersen O
- Andersson E
- Andersson G
- Andrade G
- Andrade M
- Andrea B
- Andreou C
- Antonangelo A
- Antorrena I
- Appel K
- Arana C
- Aranda M
- Araujo J
- Arce R
- Ardito RV
- Ardito W
- Arend C
- Arias V
- Armada E
- Armstrong P
- Arnold A
- Arnold M
- Arntsen BI
- Arora P
- Aros F
- Arriagada G
- Arriagada G
- Artaecheverria J
- Arvesen K
- Arvigo L
- Ash Y
- Aske R
- Ata N
- Atar D
- Atar S
- Atassi K
- Atieh M
- Atkinson C
- Atzenhofer-Baumgartner K
- Auer J
- Aug L
- Ausen K
- Aycock G
- Aylward P
- Aylward P
- Ayres T
- Azize G
- Azrin M
- Azzolini P
- Babu R
- Bach R
- Badings EA
- Baeza N
- Baig M
- Baiz A
- Bajcsi Ă
- Balaguera J
- Balcells E
- Baldari D
- Baldus S
- Bali H
- Ballantyne C
- Ballmer P
- Banerjee S
- Bang-Hansen T
- Banikova A
- Bankowski D
- Banks K
- Bansal M
- Baraona F
- Barber C
- Barber C
- Barbir M
- Barillas O
- Barnes D
- Barnett O
- Barr C
- Barrett J
- Barringhaus K
- Barron M
- Bartels GL
- Basilio E
- Bass M
- Bassand J
- Bassand JP
- Bassand JP
- Basso V
- Bata I
- Battikadi S
- Battin D
- Bauer B
- Baumanns S
- Bautista J
- Bayat J
- Bayer M
- Bayer M
- Bayles A
- Bazzi A
- Beaudry M
- Bedoya R
- Been M
- Belicova M
- Bell K
- Belle L
- Beloscar J
- Beltran R
- Beltrano MC
- Ben-Aharon J
- Ben-Yehuda O
- Benetar J
- Bengtsson PO
- Bennermo M
- Bennett J
- Benyahya L
- Beresford P
- Berezniakov I
- Berger M
- Berger-Kucza A
- Bergeron J
- Berglund M
- Berglund R
- Bergsten J
- Berk M
- Berli M
- Bernardi D
- Berra F
- Berrospi P
- Bertolet B
- Bescos L
- Bethea C
- Bethencourt A
- Betti I
- Betzu R
- Bhalla H
- Bhalodkar N
- Bhargava M
- Bhargava R
- Bhargavi M
- Bhesania T
- Biasucci L
- Biedermann B
- Bikkina M
- Bilazarian S
- Bilodeau N
- Bin Ismail O
- Binaghi G
- Birkemeyer R
- Birnbaum Y
- Bishop A
- Bishop B
- Bishop C
- Bissett J
- Bissett J
- Bittel B
- Bitzer V
- Bjornstad H
- Blacher MG
- Blais D
- Blank E
- Blazing M
- Blazing M
- Blazing M
- Blazing Michael A.
- Blessing E
- Block D
- Bluguermann J
- Blumberg E
- Bobek M
- Bocconcelli P
- Bocconcelli P
- Bodanese L
- Bodenstein W
- Boehm S
- Bogomolny N
- Bohle D
- Bohlscheid V
- Bohorquez R
- Bohula Erin A.
- Boliek W
- Bolli R
- Bolsman C
- Bonatti S
- Bondi L
- Bondio M
- Bone C
- Bonnet J
- Bono J
- Book K
- Boomer L
- Boos C
- Botero R
- Bottzauw J
- Botwin S
- Boudriot E
- Bouvier JM
- Bowden W
- Bozek B
- Bradford L
- Bradford L
- Brady A
- Brady A
- Brady A
- Braga J
- Branca G
- Branny M
- Branzi A
- Braun P
- Braunwald Eugene
- Breen J
- Brike C
- Britto F
- Britto F
- Britto F
- Broadwater S
- Bronnum-Schou J
- Brossoit R
- Brown C
- Brown C
- Brown C
- Brown J
- Brunelli C
- Brunelli C
- Brunk S
- Bruno N
- Brunvand H
- Brussee H
- Bryniarski L
- Budzon S
- Bueno M
- Buerke M
- Buerke M
- Bugos V
- Buijs EM
- Buijs F
- Bullivant M
- Burgess L
- Burghard S
- Burley T
- Burton J
- Buss I
- Bustamante G
- Butcher R
- Butkus E
- Butter C
- Buzetti C
- Byfuglien A
- Cabrera-Santamaria A
- CalderĂłn MJ
- Calic S
- Califf
- Calpar I
- Calzolari D
- Campbell C
- Campbell T
- Campos C
- Cannon C
- Cannon C
- Cannon Christopher P.
- Canto J
- Cappelen H
- Capucci A
- Capucci A
- Cardillo MT
- Cardinal F
- Cardoso A
- Carell E
- Carell E
- Carey C
- Carlessi C
- Carlevaro O
- Carling-Chambers L
- Carlsson F
- Carmelo M
- Carr K
- Carrageta M
- Carrageta M
- Carrageta M
- Carrié D
- Carswell BS
- Cartasegna L
- Caruso O
- Casalins M
- Casares G
- Caso P
- Caspi A
- Cassadonte F
- Cassavar D
- Cassel G
- Castoldi M
- Castro P
- Castro R
- Catarino C
- Caussin C
- Cauthren T
- Cavallini C
- Ceder-Brolin K
- Centeno E
- Centurion C
- Cepeda M
- Cequier A
- Chadwyn D
- Chae SC
- Chalavarya G
- Chambers J
- Chandler G
- Chandna H
- Chandna H
- Chandna H
- Chandra P
- Chandraratna P
- Chandrasekaran S
- Chang D
- Chang G
- Chang K
- Chang K
- Chang M
- Charng M
- Chattree K
- Chavarri M
- Chavez V
- Chee K
- Chernick R
- Chessa P
- Cheung S
- Chew D
- Chhabra A
- Chian-Yi W
- Chiariello M
- Chilakamarri V
- Childs A
- Childs C
- Chiodi L
- Chiu A
- Cho M
- Choi Y
- Cholewa M
- Chopra A
- Chopra V
- Christopher J
- Christy L
- Chronos N
- Chu A
- Chui K
- Chung W
- Ciampricotti R
- Cianflone D
- Cicia G
- Cihalik C
- Ciliberti D
- Cirillo W
- Ciuti G
- Cizinsky S
- Clarke A
- Clarus S
- Clausen H
- Clausen H
- Clavero X
- Clemmensen P
- Cleveland D
- Cleveland T
- Cloud B
- Cobos M
- Cocco N
- Coelho O
- Coetzee C
- Coffin N
- Coffman A
- Cohen B
- Cohen LE
- Cohen Y
- Coisne D
- Coldwell J
- Colfer H
- Collins J
- Collins J
- Collins T
- Colombo H
- Commerford P
- Conaway D
- Connolly T
- Constance C
- Conti M
- Cooke J
- Cooke L
- Corbalan R
- Corbalan R
- Corbett C
- Cortada J
- Corut S
- Cossett J
- Costa M
- Costantini C
- Costello T
- Cottin Y
- Coviaux F
- Coy K
- Craig M
- Crandall L
- Crawford K
- Cristaldi J
- Cristell N
- Cronje T
- Cross D
- Crutchfield B
- Cryderman C
- CsapĂł K
- Cubeddu L
- Cuccia C
- Cullen T
- Curry R
- Curtis S
- Cush S
- Cusimano S
- Cyncar R
- D'Urso M
- da Costa FA
- da Cunha C
- Dagefoerde N
- Dahiya R
- Dalby A
- Dalby A
- Dalby A
- Dale H
- Daley P
- Dalin L
- Dambrine P
- Damiano M
- Damiano S
- Damm T
- Dani S
- Daniel D
- Daniels MC
- Danse IY
- Darcel I
- Darius H
- Darius H
- Darius H
- Darius Harald
- Darnell Z
- Dauber I
- Dave R
- David M
- Davidovits S
- Davidson L
- Davis B
- Davis C
- Davis G
- Davis T
- Davis W
- Davy J
- Dawson G
- De Andrade M
- De Belder M
- de Carvalho Moreira R
- De Caterina R
- De Clippel M
- De Feo S
- De Ferrari G
- De Ferrari G
- De Ferrari Gaetano M.
- De Ferrari GM
- De Gregorio M
- de la Guia F
- de la Guia F
- De Larochelliere R
- de Lemos J
- De Lemos J
- De Lucca Paul
- De Maria E
- de Sa E
- de Salazar D
- de Souza J
- de Teresa E
- de Valdecilla H
- De Velder L
- De Wolf L
- Debrouwer K
- Decker S
- DeFranco A
- Del Core M
- del Rio A
- Dela Cruz C
- Delahaye F
- Delgado J
- Delio-Cox B
- Della Siega A
- Dellatorre M
- Dellborg M
- Dellborg M
- Dellborg M
- Delport E
- Demarcq JM
- Dempsey K
- Den Hartog FR
- DeRaad R
- Desai V
- Desalca M
- DeSimone L
- DeVault S
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- Ă ngman K
- Ădes I
- Ăstberg S
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit