19 research outputs found
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation
Get PDFWe carried out a trans-ancestry genome-wide association and replication study of blood pressure phenotypes among up to 320,251 individuals of East Asian, European and South Asian ancestry. We find genetic variants at 12 new loci to be associated with blood pressure (P = 3.9 × 10-11 to 5.0 × 10-21). The sentinel blood pressure SNPs are enriched for association with DNA methylation at multiple nearby CpG sites, suggesting that, at some of the loci identified, DNA methylation may lie on the regulatory pathway linking sequence variation to blood pressure. The sentinel SNPs at the 12 new loci point to genes involved in vascular smooth muscle (IGFBP3, KCNK3, PDE3A and PRDM6) and renal (ARHGAP24, OSR1, SLC22A7 and TBX2) function. The new and known genetic variants predict increased left ventricular mass, circulating levels of NT-proBNP, and cardiovascular and all-cause mortality (P = 0.04 to 8.6 × 10-6). Our results provide new evidence for the role of DNA methylation in blood pressure regulation
Milling: Particle engineering beyond size reduction
No full textPowder Engineering, Technology and Applications125-14
A novel method for stabilizing particle size of milled powders
No full textAIChE Annual Meeting, Conference Proceeding
The effects of particle surface properties and storage condition on powder flow properties
No full textAIChE Annual Meeting, Conference Proceedings
Comparative study of the triboelectric charging behavior of powders using a nonintrusive approach
No full text10.1021/ie3016973Industrial and Engineering Chemistry Research515016488-16494IECR
Novel parallel plate condenser for single particle electrostatic force measurements in atomic force microscope
No full textColloids and Surfaces A: Physicochemical and Engineering Aspects3851-3206-212CPEA
A pilot scale study on the fluidized bed binderless granulation of a humidified type C hygroscopic pharmaceutical material
No full text10.1016/j.powtec.2011.12.010Powder Technology21965-71POTE
Interpretation and applicability of empirical tissue enhancement metrics in dynamic contrast-enhanced MRI based on a multiple pathway model
No full text10.1088/0031-9155/57/15/N279Physics in Medicine and Biology5715N279-N294PHMB
