913 research outputs found
True Superconductivity in a 2D "Superconducting-Insulating" System
We present results on disordered amorphous films which are expected to
undergo a field-tuned Superconductor-Insulator Transition. Based on low-field
data and I-V characteristics, we find evidence of a low temperature
Metal-to-Superconductor transition. This transition is characterized by
hysteretic magnetoresistance and discontinuities in the I-V curves. The
metallic phase just above the transition is different from the "Fermi Metal"
before superconductivity sets in.Comment: 3 pages, 4 figure
Neighborhood Deprivation and Adverse Birth Outcomes among Diverse Ethnic Groups
Living in a socioeconomically deprived neighborhood has been associated with an increased risk of adverse birth outcomes. However, variation in the effect of neighborhood deprivation among diverse ethnic groups has not been studied
Dynamics of electrostatically-driven granular media. Effects of Humidity
We performed experimental studies of the effect of humidity on the dynamics
of electrostatically-driven granular materials. Both conducting and dielectric
particles undergo a phase transition from an immobile state (granular solid) to
a fluidized state (granular gas) with increasing applied field. Spontaneous
precipitation of solid clusters from the gas phase occurs as the external
driving is decreased. The clustering dynamics in conducting particles is
primarily controlled by screening of the electric field but is aided by
cohesion due to humidity. It is shown that humidity effects dominate the
clustering process with dielectric particles.Comment: 4 pages, 4 fig
Molecular dynamics study of accelerated ion-induced shock waves in biological media
We present a molecular dynamics study of the effects of carbon- and iron-ion induced shock waves in DNA duplexes in liquid water. We use the CHARMM force field implemented within the MBN Explorer simulation package to optimize and equilibrate DNA duplexes in liquid water boxes of different sizes and shapes. The translational and vibrational degrees of freedom of water molecules are excited according to the energy deposited by the ions and the subsequent shock waves in liquid water are simulated. The pressure waves generated are studied and compared with an analytical hydrodynamics model which serves as a benchmark for evaluating the suitability of the simulation boxes. The energy deposition in the DNA backbone bonds is also monitored as an estimation of biological damage, something which is not possible with the analytical model
Novae Ejecta as Colliding Shells
Following on our initial absorption-line analysis of fifteen novae spectra we
present additional evidence for the existence of two distinct components of
novae ejecta having different origins. As argued in Paper I one component is
the rapidly expanding gas ejected from the outer layers of the white dwarf by
the outburst. The second component is pre-existing outer, more slowly expanding
circumbinary gas that represents ejecta from the secondary star or accretion
disk. We present measurements of the emission-line widths that show them to be
significantly narrower than the broad P Cygni profiles that immediately precede
them. The emission profiles of novae in the nebular phase are distinctly
rectangular, i.e., strongly suggestive of emission from a relatively thin,
roughly spherical shell. We thus interpret novae spectral evolution in terms of
the collision between the two components of ejecta, which converts the early
absorption spectrum to an emission-line spectrum within weeks of the outburst.
The narrow emission widths require the outer circumbinary gas to be much more
massive than the white dwarf ejecta, thereby slowing the latter's expansion
upon collision. The presence of a large reservoir of circumbinary gas at the
time of outburst is suggestive that novae outbursts may sometime be triggered
by collapse of gas onto the white dwarf, as occurs for dwarf novae, rather than
steady mass transfer through the inner Lagrangian point.Comment: 12 pages, 3 figures; Revised manuscript; Accepted for publication in
Astrophysics & Space Scienc
Dark Energy and Gravity
I review the problem of dark energy focusing on the cosmological constant as
the candidate and discuss its implications for the nature of gravity. Part 1
briefly overviews the currently popular `concordance cosmology' and summarises
the evidence for dark energy. It also provides the observational and
theoretical arguments in favour of the cosmological constant as the candidate
and emphasises why no other approach really solves the conceptual problems
usually attributed to the cosmological constant. Part 2 describes some of the
approaches to understand the nature of the cosmological constant and attempts
to extract the key ingredients which must be present in any viable solution. I
argue that (i)the cosmological constant problem cannot be satisfactorily solved
until gravitational action is made invariant under the shift of the matter
lagrangian by a constant and (ii) this cannot happen if the metric is the
dynamical variable. Hence the cosmological constant problem essentially has to
do with our (mis)understanding of the nature of gravity. Part 3 discusses an
alternative perspective on gravity in which the action is explicitly invariant
under the above transformation. Extremizing this action leads to an equation
determining the background geometry which gives Einstein's theory at the lowest
order with Lanczos-Lovelock type corrections. (Condensed abstract).Comment: Invited Review for a special Gen.Rel.Grav. issue on Dark Energy,
edited by G.F.R.Ellis, R.Maartens and H.Nicolai; revtex; 22 pages; 2 figure
Bending bad—testing caramel wafer bars (#TestATunnocks)
During the coronavirus pandemic, there have been significant challenges in the remote teaching and demonstration of experiments, especially those that require laboratory testing equipment. With a desire to give students a feel for our materials laboratory on open days and allow them to gain a deeper understanding of what materials science and engineering is about, we have designed an experiment focused on composite materials that can be performed remotely and without specialist equipment. This enabled students to experience a bend test sensorily through seeing, hearing and feeling it, creating a strong link to then being able to relate it to the pre-prepared experimental data taken in the laboratory. This fun, easy-to-run and engaging experiment allowed a shared experience and encouraged a discussion about students' observations, differences in results and implications of the bend strength of sandwich composites. We have found it not only works well universally by all ages but can be used with younger children to think about words such as 'stronger', 'stiffer' and 'flexible' and how materials can be different in different directions
Spin fluctuations in nearly magnetic metals from ab-initio dynamical spin susceptibility calculations:application to Pd and Cr95V5
We describe our theoretical formalism and computational scheme for making
ab-initio calculations of the dynamic paramagnetic spin susceptibilities of
metals and alloys at finite temperatures. Its basis is Time-Dependent Density
Functional Theory within an electronic multiple scattering, imaginary time
Green function formalism. Results receive a natural interpretation in terms of
overdamped oscillator systems making them suitable for incorporation into spin
fluctuation theories. For illustration we apply our method to the nearly
ferromagnetic metal Pd and the nearly antiferromagnetic chromium alloy Cr95V5.
We compare and contrast the spin dynamics of these two metals and in each case
identify those fluctuations with relaxation times much longer than typical
electronic `hopping times'Comment: 21 pages, 9 figures. To appear in Physical Review B (July 2000
Cosmological evolution of interacting dark energy in Lorentz violation
The cosmological evolution of an interacting scalar field model in which the
scalar field interacts with dark matter, radiation, and baryon via Lorentz
violation is investigated. We propose a model of interaction through the
effective coupling . Using dynamical system analysis, we study the
linear dynamics of an interacting model and show that the dynamics of critical
points are completely controlled by two parameters. Some results can be
mentioned as follows. Firstly, the sequence of radiation, the dark matter, and
the scalar field dark energy exist and baryons are sub dominant. Secondly, the
model also allows the possibility of having a universe in the phantom phase
with constant potential. Thirdly, the effective gravitational constant varies
with respect to time through . In particular, we consider a simple
case where has a quadratic form and has a good agreement with the
modified CDM and quintessence models. Finally, we also calculate the
first post--Newtonian parameters for our model.Comment: 14 pages, published versio
SETD2 haploinsufficiency for microtubule methylation is an early driver of genomic instability in renal cell carcinoma
Loss of the short arm of chromosome 3 (3p) occurs early in >95% of clear cell renal cell carcinoma (ccRCC). Nearly ubiquitous 3p loss in ccRCC suggests haploinsufficiency for 3p tumor suppressors as early drivers of tumorigenesis. We previously reported methyltransferase SETD2, which trimethylates H3 histones on lysine 36 (H3K36me3) and is located in the 3p deletion, to also trimethylate microtubules on lysine 40 (aTubK40me3) during mitosis, with aTubK40me3 required for genomic stability. We now show that monoallelic, Setd2-deficient cells retaining H3K36me3, but not aTubK40me3, exhibit a dramatic increase in mitotic defects and micronuclei count, with increased viability compared with biallelic loss. In SETD2-inactivated human kidney cells, rescue with a pathogenic SETD2 mutant deficient for microtubule (aTubK40me3), but not histone (H3K36me3) methylation, replicated this phenotype. Genomic instability (micronuclei) was also a hallmark of patient-derived cells from ccRCC. These data show that the SETD2 tumor suppressor displays a haploinsufficiency phenotype disproportionately impacting microtubule methylation and serves as an early driver of genomic instability. Significance: Loss of a single allele of a chromatin modifier plays a role in promoting oncogenesis, underscoring the growing relevance of tumor suppressor haploinsufficiency in tumorigenesis
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