Comparisons between sediment transport models and observations made in wave and current flows above plane beds

As a part of the MAST2 G8-M Coastal Morphodynamics project, the predictions of four sediment transport models have been compared with detailed laboratory data sets obtained in the bottom boundary layer beneath regular waves, asymmetrical waves, and regular waves superimposed co-linearly on a current. Each data set was obtained in plane bed, sheet flow, conditions and each of the four untuned numerical models has provided a one-dimensional vertical (1DV), time-varying, representation of the various experimental situations. Comparisons have been made between the model predictions and measurements of both time-dependent sediment concentration, and also wave-averaged horizontal velocity and concentration. For the asymmetrical waves and for the combined wave-current flows, comparisons have been made with vertical profiles of the cycle-averaged sediment flux, and also with the vertically-integrated net sediment transport rate. Each of the turbulence diffusion models gives an accurate estimate of the net transport rate (invariably well within a factor of 2 of the measured value). In contrast, none of the models provides a good detailed description of the time-dependent suspended sediment concentration, due mainly to the inability of conventional turbulence diffusion schemes to represent the entrainment of sediment into suspension by convective events at flow reversal. However, in the cases considered here, this has not seriously affected the model predictions of the net sediment flux, due to the dominance of the near-bed transport. The comparisons in this paper are aimed not only at testing the predictive capability of existing sediment transport modelling schemes, but also at highlighting some of their deficiencies

The P Cygni supergiant [OMN2000] LS1 – implications for the star formation history of W51

Original article can be found at: http://www.aanda.org/ Copyright The European Southern Observatory (ESO) DOI: 10.1051/0004-6361/200911980Aims. We investigate the nature of the massive star [OMN2000] LS1 and use these results to constrain the history of star formation within the host complex W51. Methods. We utilised a combination of near-IR spectroscopy and non-LTE model atmosphere analysis to derive the physical properties of [OMN2000] LS1 , and a combination of theoretical evolutionary calculations and Monte Carlo simulations to apply limits on the star formation history of W51. Results. We find the spectrum of [OMN2000] LS1 to be consistent with that of a P Cygni supergiant. With a temperature in the range of 13.2–13.7 kK and log( ) , it is significantly cooler, less luminous, and less massive than proposed by previous authors. The presence of such a star within W51 shows that star formation has been underway for at least 3 Myr, while the formation of massive O stars is still on going. The lack of a population of evolved red supergiants within the complex shows that the rate of formation of young massive clusters at ages 9 Myr was lower than currently observed. We find no evidence of internally triggered, sequential star formation within W51, and favour the suggestion that star formation has proceeded at multiple indepedent sites within the GMC. Along with other examples, such as the G305 and Carina star-forming regions, we suggest that W51 is a Galactic analogue of the ubiquitous star cluster complexes seen in external galaxies such as M51 and NGC2403.Peer reviewe

The power spectrum of the circular noise

The circular noise is important in connection to Mach's principle, and also as a possible probe of the Unruh effect. In this letter the power spectrum of the detector following the Trocheries-Takeno motion in the Minkowski vacuum is analytically obtained in the form of an infinite series. A mean distribution function and corresponding energy density are obtained for this particular detected noise. The analogous of a non constant temperature distribution is obtained. And in the end, a brief discussion about the equilibrium configuration is given.Comment: accepted for publication in GR

Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3

INTRODUCTION: Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process. METHODS: We used Affymetrix oligonucleotide microarrays to perform a detailed transcript analysis on the mechanism of controlled involution after withdrawal of the pups at day seven of lactation. Some of the results were confirmed by semi-quantitative reverse transcriptase polymerase chain reaction, Western blotting or immunohistochemistry. RESULTS: We identified 145 genes that were specifically upregulated during the first 4 days of involution; of these, 49 encoded immunoglobulin genes. A further 12 genes, including those encoding the signal transducer and activator of transcription 3 (STAT3), the lipopolysaccharide receptor (CD14) and lipopolysaccharide-binding protein (LBP), were involved in the acute-phase response, demonstrating that the expression of acute-phase response genes can occur in the mammary gland itself and not only in the liver. Expression of LBP and CD14 was upregulated, at both the RNA and protein level, immediately after pup withdrawal; CD14 was strongly expressed in the luminal epithelial cells. Other genes identified suggested neutrophil activation early in involution, followed by macrophage activation late in the process. Immunohistochemistry and histological staining confirmed the infiltration of the involuting mammary tissue with neutrophils, plasma cells, macrophages and eosinophils. CONCLUSION: Oligonucleotide microarrays are a useful tool for identifying genes that are involved in the complex developmental process of mammary gland involution. The genes identified are consistent with an immune cascade, with an early acute-phase response that occurs in the mammary gland itself and resembles a wound healing process

Short-term rhGH increases PIIINP, a biomarker of endothelial dysfunction

Objectives: In arterial hypertension, amino-terminal propeptide of type III procollagen (PIIINP) is elevated in arterial aneurysm tissue and associated with a poor prognosis following acute myocardial infarction (MI). Recombinant human growth hormone (rhGH) administration attenuates endothelial dysfunction but increases PIIINP. This study was conducted to establish if short-term rhGH administration affects PIIINP, endothelial function and selected cardiovascular disease (CVD) risk factors, in healthy males. Design: Method: Male subjects (n=48) were randomly assigned into two groups: (1): control group (C) n=24, mean ± SD, age 32 ± 11 years; height 1.8 ± 0.06 metres; (2): rhGH administration group (rhGH) n=24, mean ± SD, age 32 ± 9 years; height 1.8 ± 0.07 metres. Blood pressure (BP), heart rate (HR), arterial pulse wave velocity (APWV), and biochemical indices were investigated. Results: PIIINP (0.28±0.1 vs. 0.42±0.2, U/ml); Insulin like growth factor-I (159±54 vs. 323±93, ng.mL-1); resting HR (72±14 vs. 78±11, b.p.m.) and rate pressure product (RPP) (90±18 vs. 97±14, bpm x mm.Hg x 10-2) all significantly increased (P<0.05). Total cholesterol (4.7±0.9 vs. 4.4±0.7, mmol.L-1); high sensitivity C-reactive protein (1.77±2.1 vs. 1.29±1.6, mg.L-1); serum homocysteine (13.2±4.0 vs. 11.7±3.1, μmol.L-1) and APWV (9.97±1.38 vs. 9.18±1.6, m.s-1) all significantly decreased (P<0.05). Conclusion: Paradoxically, there was an improvement in CVD inflammatory markers and APWV; but PIIINP and resting RPP increased. Elevated PIIINP may have a confounding adverse effect on the endothelium, but may also provide clinical prognostic information in monitoring arterial hypertension, left ventricular function in the sub-acute phase following MI and endothelial function in aortic aneurysms

Entanglement entropy in curved spacetimes with event horizons

We consider the computation of the entanglement entropy in curved backgrounds with event horizons. We use a Hamiltonian approach to the problem and perform numerical computations on a spherical lattice of spacing $a$. We study the cosmological case and make explicit computations for the Friedmann-Robertson-Walker universe. Our results for a massless, minimally coupled scalar field can be summarized by $S_{ent}=0.30 r_H^2/a^2$,which resembles the flat space formula, although here the horizon radius, $r_H$, is time-dependent.Comment: 12 pages, RevTex 3.0, 2 figures as uuencoded compressed Postscript file

The Impact of Ghrelin on the Survival and Efficacy of Dopaminergic Fetal Grafts in the 6-OHDA-Lesioned Rat

Ghrelin is a peptide produced in the gut with a wide range of physiological functions. Recent studies have suggested it may have potential as a neuroprotective agent in models of Parkinson’s disease, reducing the impact of toxic challenges on the survival of nigral dopaminergic neurons. The presence of the ghrelin receptor (GHSR1a) on the dopaminergic neurons of the substantia nigra raises the possibility that a potential application for this property of ghrelin may be as an adjunctive neuroprotective agent to enhance and support the survival and integration of dopaminergic cells transplanted into the striatum. Thus far, inconsistent outcomes in clinical trials for fetal cell transplantation have been linked to low rates of cell survival which we hypothesize could be ameliorated by the presence of ghrelin. To explore this, we confirmed the expression of the GHSR1a and related enzymes on e14 ventral mesencephalon. To determine a functional effect, five groups of female Sprague–Dawley rats received a unilateral 6-OHDA lesion to the medial forebrain bundle and four received an intrastriatal graft of e14 ventral mesencephalic cells. Grafted rats received saline; acyl-ghrelin (10 µg/kg); acyl-ghrelin (50 µg/kg) or the ghrelin agonist JMV-2894 (160 µg/kg) i.p. for 8 weeks. An effect of ghrelin at low dose on hippocampal neurogenesis indicated blood–brain barrier penetrance and attainment of biologically relevant levels but neither acyl-ghrelin nor JMV-2894 improved graft survival or efficacy