2,035 research outputs found
Leadership considerations for executive vice chairs, new chairs, and chairs in the 21st century.
The need to fulfill academic goals in the context of significant economic challenges, new regulatory requirements, and ever-changing expectations for leadership requires continuous adaptation. This paper serves as an educational resource for emerging leaders from the literature, national leaders, and other “best practices” in the following domains: 1. Mentorship; 2. Faculty Development; 3. Promotion; 4. Demonstrating value in each of the academic missions; 5. Marketing and communications; and 6. Barrier
Nucleation and Growth of Insulin Fibrils in Bulk Solution and at Hydrophobic Polystyrene Surfaces
AbstractA technique was developed for studying the nucleation and growth of fibrillar protein aggregates. Fourier transform infrared and attenuated total reflection spectroscopy were used to measure changes in the intermolecular β-sheet content of bovine pancreatic insulin in bulk solution and on model polystyrene (PS) surfaces at pH 1. The kinetics of β-sheet formation were shown to evolve in two stages. Combined Fourier transform infrared, dynamic light scattering, atomic force microscopy, and thioflavin-T fluorescence measurements confirmed that the first stage in the kinetics was related to the formation of nonfibrillar aggregates that have a radius of 13±1nm. The second stage was found to be associated with the growth of insulin fibrils. The β-sheet kinetics in this second stage were used to determine the nucleation and growth rates of fibrils over a range of temperatures between 60°C and 80°C. The nucleation and growth rates were shown to display Arrhenius kinetics, and the associated energy barriers were extracted for fibrils formed in bulk solution and at PS surfaces. These experiments showed that fibrils are nucleated more quickly in the presence of hydrophobic PS surfaces but that the corresponding fibril growth rates decrease. These observations are interpreted in terms of the differences in the attempt frequencies and energy barriers associated with the nucleation and growth of fibrils. They are also discussed in the context of differences in protein concentration, mobility, and conformational and colloidal stability that exist between insulin molecules in bulk solution and those that are localized at hydrophobic PS interfaces
Avalanche noise characteristics of thin GaAs structures with distributed carrier generation
It is known that both pure electron and pure hole injection into thin GaAs multiplication regions gives rise to avalanche multiplication with noise lower than predicted by the local noise model. In this paper, it is shown that the noise from multiplication initiated by carriers generated throughout a 0.1 μm avalanche region is also lower than predicted by the local model but higher than that obtained with pure injection of either carrier type. This behavior is due to the effects of nonlocal ionization brought about by the dead space; the minimum distance a carrier has to travel in the electric field to initiate an ionization even
Design and fabrication of highly efficient non-linear optical devices for implementing high-speed optical processing
We present the design and fabrication of micro-cavity semiconductor devices for enhanced Two-Photon-Absorption response, and demonstrate the use of these devices for implementing sensitive autocorrelation measurements on pico-second optical pulses
High-sensitivity two-photon absorption microcavity autocorrelator
A GaAs-AlAs microcavity device has been used as a photodetector in an autocorrelator for measuring the temporal pulsewidth of 1.5-/spl mu/m optical pulses. Enhancement of the two-photon absorption photocurrent due to the microcavity structure results in an autocorrelation (average power times peak power) sensitivity of 9.3/spl times/10/sup -4/ (mW)/sup 2/, which represents two orders of magnitude improvement when compared with conventional autocorrelators
Two-photon absorption in microcavities for optical autocorrelation and sampling
We have designed novel semiconductor microcavity structures for the enhancement of the two-photon absorption (TPA) photocurrent. We report a TPA autocorrelation technique for short optical pulses that uses the microcavity structure instead of a second harmonic generation crystal. Knowledge of these characteristics is important for implementation in applications such as optical switching and sampling in optical time division multiplexed (OTDM) communications systems
Dyson-Schwinger Equations - aspects of the pion
The contemporary use of Dyson-Schwinger equations in hadronic physics is
exemplified via applications to the calculation of pseudoscalar meson masses,
and inclusive deep inelastic scattering with a determination of the pion's
valence-quark distribution function.Comment: 4 pages. Contribution to the Proceedings of ``DPF 2000,'' the Meeting
of the Division of Particles and Fields of the American Physical Society,
August 9-12, 2000, Department of Physics, the Ohio State University,
Columbus, Ohi
A novel approach towards two-photon absorption based detectors
Summary: We have demonstrated that the inherent inefficiency of the TPA process in semiconductors can be overcome by incorporating the semiconductor in a microcavity structure. Proof of concept devices with a 0.27μm Ga0.7Al0.3As active region and two Bragg reflectors with the cavity resonance of 890 nm were fabricated. We measured the TPA photocurrent of these devices and have demonstrated a factor of 12000 enhancement over a nonmicrocavity device at 890 nm. Our active length of 0.27 nm is as efficient as 5.4 mm without a microcavity, overcoming the very long detector lengths limiting the use of TPA in practical autocorrelators, optical switches and sampling devices for real telecommunication systems. The effect of the cavity is to enhance the intra-cavity optical intensity, which leads to an increase in the nonlinear response of the active region. We studied, theoretically and experimentally, the impact of the cavity on the temporal response and the sensitivity of the device, which are critical considerations for commercial applications. This cavity design has a 3 pico-second response time and the autocorrelation trace is comparable with the BBO crystal response for an input 1.6 ps pulse. Devices designed for 1550 nm have also been realised and our measurements indicate these two-photon absorption based detectors are potential candidates for optical autocorrelation of short optical pulses, and for optical switching and sampling in optical time division multiplexed (OTDM) communications systems
Quantum well and dot self-aligned stripe lasers utilizing an InGaP optoelectronic confinement layer
We demonstrate and study a novel process for fabrication of GaAs-based self-aligned lasers based upon a single over-growth. A lattice-matched n-doped InGaP layer is utilized for both electrical and optical confinements. Single-lateral-mode emission is demonstrated initially from an In0.17Ga0.83 As double quantum well laser emitting similar to 980 nm. We then apply the fabrication technique to a quantum dot laser emitting similar to 1300 nm. Furthermore, we analyze the breakdown mechanism in our devices and discuss the limitations of index guiding in our structures
High power femtosecond source based on passively mode-locked 1055nm VECSEL and Yb-fibre power amplifier
We report 5 ns pulses at 160 W average power and 910 repetition rate from a passively mode-locked VECSEL source seeding an Yb-doped fibre power amplifier. The amplified pulses were compressed to 291 fs duration
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