51 research outputs found
Enhanced hippocampal long-term potentiation and spatial learning in aged 11ß-hydroxysteroid dehydrogenase type 1 knock-out mice
Glucocorticoids are pivotal in the maintenance of memory and cognitive functions as well as other essential physiological processes including energy metabolism, stress responses, and cell proliferation. Normal aging in both rodents and humans is often characterized by elevated glucocorticoid levels that correlate with hippocampus-dependent memory impairments. 11ß-Hydroxysteroid dehydrogenase type 1 (11ß-HSD1) amplifies local intracellular ("intracrine") glucocorticoid action; in the brain it is highly expressed in the hippocampus. We investigated whether the impact of 11ß-HSD1 deficiency in knock-out mice (congenic on C57BL/6J strain) on cognitive function with aging reflects direct CNS or indirect effects of altered peripheral insulin-glucose metabolism. Spatial learning and memory was enhanced in 12 month "middle-aged" and 24 month "aged" 11ß-HSD1<sup>–/–</sup> mice compared with age-matched congenic controls. These effects were not caused by alterations in other cognitive (working memory in a spontaneous alternation task) or affective domains (anxiety-related behaviors), to changes in plasma corticosterone or glucose levels, or to altered age-related pathologies in 11ß-HSD1<sup>–/–</sup> mice. Young 11ß-HSD1<sup>–/–</sup> mice showed significantly increased newborn cell proliferation in the dentate gyrus, but this was not maintained into aging. Long-term potentiation was significantly enhanced in subfield CA1 of hippocampal slices from aged 11ß-HSD1<sup>–/–</sup> mice. These data suggest that 11ß-HSD1 deficiency enhances synaptic potentiation in the aged hippocampus and this may underlie the better maintenance of learning and memory with aging, which occurs in the absence of increased neurogenesis
Fractal Spacetime Structure in Asymptotically Safe Gravity
Four-dimensional Quantum Einstein Gravity (QEG) is likely to be an
asymptotically safe theory which is applicable at arbitrarily small distance
scales. On sub-Planckian distances it predicts that spacetime is a fractal with
an effective dimensionality of 2. The original argument leading to this result
was based upon the anomalous dimension of Newton's constant. In the present
paper we demonstrate that also the spectral dimension equals 2 microscopically,
while it is equal to 4 on macroscopic scales. This result is an exact
consequence of asymptotic safety and does not rely on any truncation. Contact
is made with recent Monte Carlo simulations.Comment: 20 pages, late
Galaxy rotation curves: the effect of j x B force
Using the Galaxy as an example, we study the effect of j x B force on the
rotational curves of gas and plasma in galaxies. Acceptable model for the
galactic magnetic field and plausible physical parameters are used to fit the
flat rotational curve for gas and plasma based on the observed baryonic
(visible) matter distribution and j x B force term in the static MHD equation
of motion. We also study the effects of varied strength of the magnetic field,
its pitch angle and length scale on the rotational curves. We show that j x B
force does not play an important role on the plasma dynamics in the
intermediate range of distances 6-12 kpc from the centre, whilst the effect is
sizable for larger r (r > 15 kpc), where it is the most crucial.Comment: Accepted for publication in Astrophysics & Space Science (final
printed version, typos in proofs corrected
Matrix theory of gravitation
A new classical theory of gravitation within the framework of general
relativity is presented. It is based on a matrix formulation of
four-dimensional Riemann-spaces and uses no artificial fields or adjustable
parameters. The geometrical stress-energy tensor is derived from a matrix-trace
Lagrangian, which is not equivalent to the curvature scalar R. To enable a
direct comparison with the Einstein-theory a tetrad formalism is utilized,
which shows similarities to teleparallel gravitation theories, but uses complex
tetrads. Matrix theory might solve a 27-year-old, fundamental problem of those
theories (sec. 4.1). For the standard test cases (PPN scheme,
Schwarzschild-solution) no differences to the Einstein-theory are found.
However, the matrix theory exhibits novel, interesting vacuum solutions.Comment: 24 page
The role of Background Independence for Asymptotic Safety in Quantum Einstein Gravity
We discuss various basic conceptual issues related to coarse graining flows
in quantum gravity. In particular the requirement of background independence is
shown to lead to renormalization group (RG) flows which are significantly
different from their analogs on a rigid background spacetime. The importance of
these findings for the asymptotic safety approach to Quantum Einstein Gravity
(QEG) is demonstrated in a simplified setting where only the conformal factor
is quantized. We identify background independence as a (the ?) key prerequisite
for the existence of a non-Gaussian RG fixed point and the renormalizability of
QEG.Comment: 2 figures. Talk given by M.R. at the WE-Heraeus-Seminar "Quantum
Gravity: Challenges and Perspectives", Bad Honnef, April 14-16, 2008; to
appear in General Relativity and Gravitatio
Can the Pioneer anomaly be of gravitational origin? A phenomenological answer
In order to satisfy the equivalence principle, any non-conventional mechanism
proposed to gravitationally explain the Pioneer anomaly, in the form in which
it is presently known from the so-far analyzed Pioneer 10/11 data, cannot leave
out of consideration its impact on the motion of the planets of the Solar
System as well, especially those orbiting in the regions in which the anomalous
behavior of the Pioneer probes manifested itself. In this paper we, first,
discuss the residuals of the right ascension \alpha and declination \delta of
Uranus, Neptune and Pluto obtained by processing various data sets with
different, well established dynamical theories (JPL DE, IAA EPM, VSOP). Second,
we use the latest determinations of the perihelion secular advances of some
planets in order to put on the test two gravitational mechanisms recently
proposed to accommodate the Pioneer anomaly based on two models of modified
gravity. Finally, we adopt the ranging data to Voyager 2 when it encountered
Uranus and Neptune to perform a further, independent test of the hypothesis
that a Pioneer-like acceleration can also affect the motion of the outer
planets of the Solar System. The obtained answers are negative.Comment: Latex2e, 26 pages, 6 tables, 2 figure, 47 references. It is the
merging of gr-qc/0608127, gr-qc/0608068, gr-qc/0608101 and gr-qc/0611081.
Final version to appear in Foundations of Physic
Recommended from our members
The final SDSS-IV/SPIDERS X-ray point source spectroscopic catalogue
Aims. We look to provide a detailed description of the SPectroscopic IDentification of ERosita Sources (SPIDERS) survey, an SDSS-IV programme aimed at obtaining spectroscopic classification and redshift measurements for complete samples of sufficiently bright X-ray sources.
Methods. We describe the SPIDERS X-ray Point Source Spectroscopic Catalogue, considering its store of 11 092 observed spectra drawn from a parent sample of 14 759 ROSAT and XMM sources over an area of 5129 deg2 covered in SDSS-IV by the eBOSS survey.
Results. This programme represents the largest systematic spectroscopic observation of an X-ray selected sample. A total of 10 970 (98.9%) of the observed objects are classified and 10 849 (97.8%) have secure redshifts. The majority of the spectra (10 070 objects) are active galactic nuclei (AGN), 522 are cluster galaxies, and 294 are stars.
Conclusions. The observed AGN redshift distribution is in good agreement with simulations based on empirical models for AGN activation and duty cycle. Forming composite spectra of type 1 AGN as a function of the mass and accretion rate of their black holes reveals systematic differences in the H-beta emission line profiles. This study paves the way for systematic spectroscopic observations of sources that are potentially to be discovered in the upcoming eROSITA survey over a large section of the sky
- …