A divergent cyclin/cyclin-dependent kinase complex controls the atypical replication of a malaria parasite during gametogony and transmission

Cell cycle transitions are generally triggered by variation in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have a life cycle with unique cell-division cycles, and a repertoire of divergent CDKs and cyclins of poorly understood function and interdependency. We show that Plasmodium berghei CDK-related kinase 5 (CRK5), is a critical regulator of atypical mitosis in the gametogony and is required for mosquito transmission. It phosphorylates canonical CDK motifs of components in the pre-replicative complex and is essential for DNA replication. During a replicative cycle, CRK5 stably interacts with a single Plasmodium-specific cyclin (SOC2), although we obtained no evidence of SOC2 cycling by transcription, translation or degradation. Our results provide evidence that during Plasmodium male gametogony, this divergent cyclin/CDK pair fills the functional space of other eukaryotic cell-cycle kinases controlling DNA replication

Diving into the vertical dimension of elasmobranch movement ecology

Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements

Les Entrainements a vitesse variable par moteurs electriques

SIGLECNRS RP 270 (187) / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Long period/large scale oscillations of temperature during the DYANA campaign

International audienceDuring the DYANA campaign (January-March 1990) vertical temperature profiles were measured in the middle atmosphere above 11 rocket and four lidar stations in the northern hemisphere. Strong temperature variations were observed, especially at the medium to high latitude stations. Time series analysis was applied, and most oscillations were found to be quasi-periodic only, and restricted to certain altitude levels. Solely the longest periods (>4 weeks) and the shortest periods (around 5 days) were consisterrtly observed in the whole altitude regime, and were, therefore, further analysed. These temperature variations were found to be compatible with the assumption that the Quasi-Stationary Planetary Wave No. 1 (QSW 1) of the CIRA 1990 Model Atmosphere was modulated with the respective periods. Especially close similarity of the vertical phase structures was obtained. The amplitudes measured were, however, much larger than those of the model, and hence some amendment to the model may be appropriate. The importance of QSW 1 modulation appears to be considerable, as more than 50% of the temperature variance could be ascribed to it. The DYANA results were checked by an analysis of respective data from two other campaigns (Winter Anomaly campaign, 1976, and MAP/WINE campaign, 1984). Essentially the same results were obtained. Considering the strength of QSW 1 control, the midwinter middle atmosphere shows itself to be quite strongly and persisterrtly structured in both the vertical and horizontal directions. This applies to all parts of the stratosphere and mesosphere

The upper Cretaceous-lower Tertiary marine to continental transition in the Bagua basin, northern Peru : paleontology, biostratigraphy, radiometry, correlations

L'étude détaillée des fossiles d'invertébrés, de vertébrés, de restes végétaux ainsi que les déterminations radiométriques permettent d'établir l'âge des formations de Celendin et de Bagua, dans le synclinal de Bagua (nord du Pérou). L'émersion de cette zone andine se réalise donc entre le Campanien inférieur et le Maastrichtien inférieur. Les restes végétaux de charophytes présents dans la formation Bagua fournissent le principal support d'une corrélation depuis le nord du Pérou jusqu'au sud de la Bolivie, entre des unités référées au Campano-Maastrichtien et, d'autre part, des unités référées au Paléocène-Eocène inférieu