Editorial: Cancer Nanotheranostics: What Have We Learned So Far?

According to the National Cancer Institute, in 2015 an estimated of 1.7 million new cases of cancer will be diagnosed only in the United States and around 600, 000 people will die from the disease. The most common type of cancer is breast cancer, with more than 234, 000 new cases expected in the United States in 2015. The next most common cancers are prostate cancer and lung cancer.After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. These transformations trigger a range of modification to cell processes and molecular events that initiate and promote tumor genesis and progression, then local invasion and metastasis, i.e., the hallmarks of cancer development. These alterations may cause a wide scope of “diseases” that share similar molecular patterns that cause transformation and malignancy. Each of this stepwise evolution of the initial molecular event drives abnormal growth and loss of differentiation that ultimately causes tissue and organ failure. The initial molecular event may lay within the erroneous expression of a given gene, epigenetic modification and/or sporadic mutations occurring on genomic DNA during the life span of organisms. Each and every one of these molecular events may be evaluated and used as diagnostics biomarker and therapeutic target. For example, therapy action may target a mutated gene and silence its expression so as to avoid erroneous protein expression that mutates cell function. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely..

Explosive events - swirling transition region jets

In this paper, we extend our earlier work to provide additional evidence for an alternative scenario to explain the nature of so-called `explosive events'. The bi-directed, fast Doppler motion of explosive events observed spectroscopically in the transition region emission is classically interpreted as a pair of bidirectional jets moving upward and downward from a reconnection site. We discuss the problems of such a model. In our previous work, we focused basically on the discrepancy of fast Doppler motion without detectable motion in the image plane. We now suggest an alternative scenario for the explosive events, based on our observations of spectral line tilts and bifurcated structure in some events. Both features are indicative of rotational motion in narrow structures. We explain the bifurcation as the result of rotation of hollow cylindrical structures and demonstrate that such a sheath model can also be applied to explain the nature of the puzzling `explosive events'. We find that the spectral tilt, the lack of apparent motion, the bifurcation, and a rapidly growing number of direct observations support an alternative scenario of linear, spicular-sized jets with a strong spinning motion.Comment: 9 pages, 3 figures, accepted for publication in Solar Physic

The classical R-matrix of AdS/CFT and its Lie dialgebra structure

The classical integrable structure of Z_4-graded supercoset sigma-models, arising in the AdS/CFT correspondence, is formulated within the R-matrix approach. The central object in this construction is the standard R-matrix of the Z_4-twisted loop algebra. However, in order to correctly describe the Lax matrix within this formalism, the standard inner product on this twisted loop algebra requires a further twist induced by the Zhukovsky map, which also plays a key role in the AdS/CFT correspondence. The non-ultralocality of the sigma-model can be understood as stemming from this latter twist since it leads to a non skew-symmetric R-matrix.Comment: 22 pages, 2 figure

Entropic force and its cosmological implications

We investigate a possibility of realizing the entropic force into the cosmology. A main issue is how the holographic screen is implemented in the Newtonian cosmology. Contrary to the relativistic realization of Friedmann equations, we do not clarify the connection between Newtonian cosmology and entropic force because there is no way of implementing the holographic screen in the Newtonian cosmology.Comment: 16 pages, no figures, version "Accepted for publication in Astrophysics & Space Science

Dibaryon Spectroscopy

The AdS/CFT correspondence relates dibaryons in superconformal gauge theories to holomorphic curves in Kaehler-Einstein surfaces. The degree of the holomorphic curves is proportional to the gauge theory conformal dimension of the dibaryons. Moreover, the number of holomorphic curves should match, in an appropriately defined sense, the number of dibaryons. Using AdS/CFT backgrounds built from the generalized conifolds of Gubser, Shatashvili, and Nekrasov (1999), we show that the gauge theory prediction for the dimension of dibaryonic operators does indeed match the degree of the corresponding holomorphic curves. For AdS/CFT backgrounds built from cones over del Pezzo surfaces, we are able to match the degree of the curves to the conformal dimension of dibaryons for the n'th del Pezzo surface, n=1,2,...,6. Also, for the del Pezzos and the A_k type generalized conifolds, for the dibaryons of smallest conformal dimension, we are able to match the number of holomorphic curves with the number of possible dibaryon operators from gauge theory.Comment: 30 pages, 6 figures, corrected refs; v3 typos correcte

New checks and subtleties for AdS/CFT and a-maximization

We provide a cross-check of AdS/CFT and a-charge maximization for a four dimensional $N$=1 SCFT with irrational R-charges. The gauge theory is the low energy effective theory of N D3-branes at the tip of the complex cone over the first del Pezzo surface. By carefully taking into account the subtle issue of flavor symmetry breaking at the fixed point, we show, using a-maximization, that this theory has in fact irrational central charge and R-charges. Our results perfectly match with those inherited from the recently discovered supergravity dual background. Along analogous lines, we make novel predictions for the still unknown AdS dual of the quiver theory for the second del Pezzo surface. This should flow to a SCFT with irrational charges, too. All of our results differ from previous findings in the literature and outline interesting subtleties in a-maximization and AdS/CFT techniques overlooked in the past.Comment: Latex, 16 pagex, 2 figures; v2, comments and a reference added; v3, typos correcte

Monolithically Integrated Temperature Sensor in an InP-based Generic Integration Technology

We have developed various monolithically integrated temperature sensors to locally measure the temperature of InP-based photonic integrated circuits. These sensors are based on InP diodes with either an active multi-quantum well structure or a passive bulk quaternary structure. They have been fabricated in the generic integration process of SMART Photonics. We theoretically and experimentally explored the temperature dependence in the diode characteristics. Our results show that the devices are suitable for on-chip monitoring of the operating temperature of photonic integrated circuits. Integrating a temperature sensor on-chip enables a more local temperature measurement compared to using an external temperature sensor. This should be advantageous for temperature control of photonic integrated circuits

Josephson-phase qubit without tunneling

We show that a complete set of one-bit gates can be realized by coupling the two logical states of a phase qubit to a third level (at higher energy) using microwave pulses. Thus, one can achieve coherent control without invoking any tunneling between the qubit levels. We propose two implementations, using rf-SQUIDs and d-wave Josephson junctions.Comment: REVTeX4, 4pp., 6 EPS figure files; N.B.: "Alec" is my first, and "Maassen van den Brink" my family name. v2: gate universality fleshed out, small fix in d-wave decoherence para, discussion expanded, two Refs. added. v3: some more Refs., a molecular example, and a few minor fixes; final, to appear in PRB Rapid