The rheology of three-phase suspensions at low bubble capillary number

We develop a model for the rheology of a three-phase suspension of bubbles and particles in a Newtonian liquid undergoing steady flow. We adopt an ‘effective-medium’ approach in which the bubbly liquid is treated as a continuous medium which suspends the particles. The resulting three-phase model combines separate two-phase models for bubble suspension rheology and particle suspension rheology, which are taken from the literature. The model is validated against new experimental data for three-phase suspensions of bubbles and spherical particles, collected in the low bubble capillary number regime. Good agreement is found across the experimental range of particle volume fraction (0≤ϕp≲0.5) and bubble volume fraction (0≤ϕb≲0.3). Consistent with model predictions, experimental results demonstrate that adding bubbles to a dilute particle suspension at low capillarity increases its viscosity, while adding bubbles to a concentrated particle suspension decreases its viscosity. The model accounts for particle anisometry and is easily extended to account for variable capillarity, but has not been experimentally validated for these cases

Developmental regulation of voltage-gated K+ channel and GABAA receptor expression in Bergmann glial cells

Bergmann glial cells are closely associated with neurons: during development they provide guiding structures for migrating granule cells and in the adult cerebellum they display intimate interactions with Purkinje cells. In this study, we have addressed the question of whether such changes in neuronal-glial interactions during development are accompanied by variations in the membrane properties of Bergmann glial cells. We used a mouse cerebellum slice preparation to study membrane currents of the Bergmann glial cells at various stages of development in situ using the patch-clamp technique. The distinct morphology of Bergmann glial cells was revealed by Lucifer yellow injections during recording. While Bergmann glial cells in mice of postnatal day 20 (P20) to P30 have thick processes with arborized, irregularly shaped leaf-like appendages, the processes of cells from younger mice (P5-P7) are thinner and smoother. This morphological maturation is accompanied by a variation in voltage-gated currents. In cells from P5 to P7, delayed outward- and inward-rectifying K+ currents were recorded, while older Bergmann glial cells were characterized by, large, voltage- and time-independent K+ currents. In addition, application of GABA induces two effects, a rapid activation of a Cl- conductance and a longer-lasting decrease in the (resting) K+ conductance. Both effects were mediated by benzodiazepine-insensitive GABAA receptors. Responses in cells of P5-P7 mice were large as compared to the small or even undetectable responses in P20-P30 cells. These GABAA receptors were characterized immunohistochemically in mice and rat brain sections with five subunit-specific antibodies. Bergmann glial cells exhibit a distinct but transient immunoreactivity for the GABAA receptor alpha 2-, alpha 3-, and delta-subunits. Staining is maximal between P7 and P10 and decreases gradually thereafter. In contrast, antibodies to the alpha 1- and beta 2,3-subunits fail to decorate Bergmann glial cells, although they yield a prominent staining of both the Purkinje cells and the granule cells. These changes in the Bergmann glial cell membrane properties and GABAA receptor expression suggest a transition between functional states during development of the Bergmann glial cells

Heavy-quark energy loss in pQCD and SYM plasmas

We consider heavy-quark energy loss and pT-broadening in a strongly-coupled N=4 Super Yang Mills (SYM) plasma, and the problem of finite-extend matter is addressed. When expressed in terms of the appropriate saturation momentum, one finds identical parametric forms for the energy loss in pQCD and SYM theory, while pT-broadening is radiation dominated in SYM theory and multiple scattering dominated in pQCD.Comment: 5 pages, 2 figures, Proceedings of the IIIrd Workshop for Young Scientists on the Physics of Ultrarelativistic Nucleus-Nucleus Collisions (HotQuarks08), Estes Park, USA, August 18-23 200

Strange form factors of the proton: a new analysis of the neutrino (antineutrino) data of the BNL-734 experiment

We consider ratios of elastic neutrino(antineutrino)-proton cross sections measured by the Brookhaven BNL-734 experiment and use them to obtain the neutral current (NC) over charged current (CC) neutrino-antineutrino asymmetry. We discuss the sensitivity of these ratios and of the asymmetry to the electric, magnetic and axial strange form factors of the nucleon and to the axial cutoff mass M_A. We show that the effects of the nuclear structure and interactions on the asymmetry and, in general, on ratios of cross sections are negligible. We find some restrictions on the possible values of the parameters characterizing the strange form factors. We show that a precise measurement of the neutrino-antineutrino asymmetry would allow the extraction of the axial and vector magnetic strange form factors in a model independent way. The neutrino-antineutrino asymmetry turns out to be almost independent on the electric strange form factor and on the axial cutoff mass.Comment: 12 page

Magnetic resonance elastography reveals altered brain viscoelasticity in experimental autoimmune encephalomyelitis

Cerebral magnetic resonance elastography (MRE) measures the viscoelastic properties of brain tissues in vivo. It was recently shown that brain viscoelasticity is reduced in patients with multiple sclerosis (MS), highlighting the potential of cerebral MRE to detect tissue pathology during neuroinflammation. To further investigate the relationship between inflammation and brain viscoelasticity, we applied MRE to a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). EAE was induced and monitored by MRE in a 7-tesla animal MRI scanner over 4 weeks. At the peak of the disease (day 14 after immunization), we detected a significant decrease in both the storage modulus (G') and the loss modulus (G″), indicating that both the elasticity and the viscosity of the brain are reduced during acute inflammation. Interestingly, these parameters normalized at a later time point (day 28) corresponding to the clinical recovery phase. Consistent with this, we observed a clear correlation between viscoelastic tissue alteration and the magnitude of perivascular T cell infiltration at both day 14 and day 28. Hence, acute neuroinflammation is associated with reduced mechanical cohesion of brain tissues. Moreover, the reduction of brain viscoelasticity appears to be a reversible process, which is restored when inflammation resolves. For the first time, our study has demonstrated the applicability of cerebral MRE in EAE, and showed that this novel imaging technology is highly sensitive to early tissue alterations resulting from the inflammatory processes. Thus, MRE may serve to monitor early stages of perivascular immune infiltration during neuroinflammation

Nuclear transparencies in relativistic A(e,e'p) models

Relativistic and unfactorized calculations for the nuclear transparency extracted from exclusive A(e,e'p) reactions for 0.3 \leq Q^2 \leq 10 (GeV/c)^2 are presented for the target nuclei C, Si, Fe and Pb. For Q^2 \geq 0.6 (GeV/c)^2, the transparency results are computed within the framework of the recently developed relativistic multiple-scattering Glauber approximation (RMSGA). The target-mass and Q^2 dependence of the RMSGA predictions are compared with relativistic distorted-wave impulse approximation (RDWIA) calculations. Despite the very different model assumptions underlying the treatment of the final-state interactions in the RMSGA and RDWIA frameworks, they predict comparable nuclear transparencies for kinematic regimes where both models are applicable.Comment: 15 pages, 4 figure

Deep inelastic scattering off a N=4 SYM plasma at strong coupling

By using the AdS/CFT correspondence we study the deep inelastic scattering of an R-current off a N=4 supersymmetric Yang-Mills (SYM) plasma at finite temperature and strong coupling. Within the supergravity approximation valid when the number of colors is large, we compute the structure functions by solving Maxwell equations in the space-time geometry of the AdS_5 black three-brane. We find a rather sharp transition between a low energy regime where the scattering is weak and quasi-elastic, and a high-energy regime where the current is completely absorbed. The critical energy for this transition determines the plasma saturation momentum in terms of its temperature T and the Bjorken x variable: Q_s=T/x. These results suggest a partonic picture for the plasma where all the partons have transverse momenta below the saturation momentum and occupation numbers of order one.Comment: Version accepted for publication in JHEP: more references added; some technical points were displaced from Sect. 4 to the new Appendix

Hadronic Parity Violation and Inelastic Electron-Deuteron Scattering

We compute contributions to the parity-violating (PV) inelastic electron-deuteron scattering asymmetry arising from hadronic PV. While hadronic PV effects can be relatively important in PV threshold electro- disintegration, we find that they are highly suppressed at quasielastic kinematics. The interpretation of the PV quasielastic asymmetry is, thus, largely unaffected by hadronic PV.Comment: 27 pages, 13 figures, uses REVTeX and BibTe