524 research outputs found
Carotid Artery Stenting and Endarterectomy: a clinical evaluation
Stroke is a major cause of mortality and morbidity in the western world. Atherosclerotic disease
of the carotid arteries is in approximately 25% of the cases responsible for the cerebral
infarction.1 Since NASCET and ECST, carotid endarterectomy (CEA) is considered the standard
treatment for severe atherosclerotic carotid obstructive disease in symptomatic patients.2, 3
Similar landmark studies were performed for asymptomatic carotid artery disease.4, 5 On the
basis of these trials the American Heart Association has recommended CEA for symptomatic
patients with stenosis of 50% to 99% if the perioperative risk of stroke or death is <6%.6 In
asymptomatic patients CEA is recommended for a stenosis of 60% to 99% if the perioperative
of stroke or death is < 3%.
In an effort to minimise interventions, in the last decade carotid artery stenting (CAS) has
been suggested as an alternative to surgical endarterectomy for patients with symptomatic
and asymptomatic extra cranial obstructive disease. Initially, percutaneous transluminal balloon
angioplasty (PTA) was used. Later stent placement was introduced and has been used with
or without initial PTA. Current data on CAS and CEA suggest that CAS is quickly gaining ground
on CEA as a first-line treatment
The advantages of CAS include avoidance of general anaesthesia, an incision in the neck
and the risk of cranial and cutaneous nerve damage from the dissection. Surgically inaccessible
lesion can be treated with CAS and both procedure- and admission times are usually shorter
than for surgery, therefore reducing some cost. On the other hand, devices used for CAS are
more expensive.
At this moment many interventionists embrace carotid stenting, in particular for patients
with obvious contraindications for surgical endarterectomy like high cardiopulmonary risk,
high cervical lesion or βhostile neckβ.
CAS is relatively new compared to CEA and it should be acknowledged that CAS is an evolving
technique and dedicated materials became only available recently
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A tillering inhibition gene influences root-shoot carbon partitioning and pattern of water use to improve wheat productivity in rainfed environments
Genetic modification of shoot and root morphology has potential to improve water and nutrient
19 uptake of wheat crops in rainfed environments. Near-isogenic lines (NILs) varying for a tillering
20 inhibition (tin) gene and representing multiple genetic backgrounds were investigated in contrasting
21 controlled environments for shoot and root growth. Leaf area, shoot and root biomass were similar
22 until tillering whereupon reduced tillering in tin-containing NILs produced reductions of up to 60% in
23 total leaf area and biomass, and increases in total root length of up to 120% and root biomass to
24 145%. Together, root-to-shoot ratio increased two-fold with the tin gene. The influence of tin on shoot
25 and root growth was greatest in the cv. Banks genetic background, particularly in the biculm-selected
26 NIL, and was typically strongest in cooler environments. A separate de-tillering study confirmed
27 greater root-to-shoot ratios with regular tiller removal in non-tin containing genotypes. In validating
28 these observations in a rainfed field study, the tin allele had a negligible effect on seedling growth but
29 was associated with significantly (P<0.05) reduced tiller number (-37%), leaf area index (-26%) and
30 spike number (-35%) to reduce plant biomass (-19%) at anthesis. Root biomass, root-to-shoot ratio at
31 early stem elongation and root depth at maturity were increased in tin-containing NILs. Soil water use
32 was slowed in tin-containing NILs resulting in greater water availability, greater stomatal
33 conductance, cooler canopy temperatures and maintenance of green leaf area during grain-filling.
34 Together these effects contributed to increases in harvest index and grain yield. In both the controlled
35 and field environments, the tin gene was commonly associated with increased root length and biomass
36 but the significant influence of genetic background and environment suggests careful assessment of
37 tin-containing progeny in selection for genotypic increases in root growth
Uitbreidingsmogelijkheden voor Douglas (Pseudotsuga menziesii) binnen het huidige Nederlandse bosareaal : eerste evaluatie van het meerjarenplan bosbouw
Supplementation of lamb diets with vitamin E and rosemary extracts on meat quality parameters
BACKGROUND Supranutritional supplementation of lamb diets with alpha-tocopherol is an effective method to reduce lipid oxidation and colour deterioration in meat products. However, alternative antioxidant sources have been proposed to replace the supranutritional vitamin E applications. RESULTS Indoor concentrate-fed Rasa Aragonesa male lambs (n = 480) were supplemented with increasing levels of all-rac-alpha-tocopheryl acetate (0.25, 0.5, 1.0 g kg(-1) compound feed), rosemary extract (0.20, 0.40, or 0.80 g kg(-1) compound feed), or rosemary extract embedded in a fat matrix (0.20, 0.40, or 0.80 g kg(-1) compound feed) for 14 days before slaughter. The longissimus thoracis et lumborum muscle from three lambs per pen (18 lambs per treatment) were modified-atmosphere packaged (70% O-2 + 30% CO2) and maintained under retail conditions for 14 days. Supranutritional supplementation with antioxidants had no effect (P > 0.05) on average daily weight gain, feed intake, and feed efficiency. Rosemary extract supplementation (with or without fat embedment) had no effect on lipid oxidation, myoglobin forms, or colour stability parameters, regardless of the dose. All vitamin E supplementation levels significantly affected lipid oxidation, colour stability (L*, C*, and h), myoglobin forms, and meat discoloration parameters compared with non-supplemented lambs. CONCLUSIONS This study demonstrates that, unlike vitamin E, neither dose nor protection of the rosemary extract had an effect on lipid oxidation or meat colour stability of lambs during the 14 days of storage under retail conditions
Review of a major epidemic of methicillin-resistant Staphylococcus aureus: The costs of screening and consequences of outbreak management
Background: A major outbreak of methicillin-resistant Staphylococcus aureus (MRSA) occurred in locations C and Z of our hospital and lasted for several years. It affected 1,230 patients and 153 personnel. Methods: Outbreak management was installed according to the Dutch "search and destroy" policy. A rapid, high-throughput method for molecular screening of potential MRSA carriers was implemented. Outbreak isolates were retrospectively genotyped by pulsed field gel electrophoresis. Costs of molecular screening were compared with screening by culture. Results: Genotyping results revealed 4 distinct epidemic MRSA clones. Three were present in hospital C. Because of a merger of hospitals, these clones spread to hospital Z. Another clone of MRSA affected other health care-related institutions in the region. Because of the implementation of strict containment measures of the "search and destroy" policy, the annual number of tests decreased from 100,000 to 18,000. The disposables and reagents used in polymerase chain reaction technology are more expensive than those of conventional methods. However, the clinical and economic benefits of fast results in regard to expenses of the hospital clearly outweigh the higher costs of screening. Conclusion: The implementation of a rapid, high-throughput molecular screening system greatly contributed to the effectiveness of strict containment measures of the "search and destroy" policy. The major epidemic clones of MRSA in the outbreak were eradicated by this strategy
Static and Dynamic Predictors of General and Violent Criminal Offense Recidivism in the Forensic Outpatient Population: A Meta-Analysis
Static and Dynamic Predictors of General and Violent Criminal Offense Recidivism in the Forensic Outpatient Population: A Meta-Analysis
Toward complete oral cavity cancer resection using a handheld diffuse reflectance spectroscopy probe
This ex-vivo study evaluates the feasibility of diffuse reflectance spectroscopy (DRS) for discriminating tumor from healthy tissue, with the aim to develop a technology that can assess resection margins for the presence of tumor cells during oral cavity cancer surgery. Diffuse reflectance spectra were acquired on fresh surgical specimens from 28 patients with oral cavity squamous cell carcinoma. The spectra (400 to 1600 nm) were detected after illuminating tissue with a source fiber at 0.3-, 0.7-, 1.0-, and 2.0-mm distances from a detection fiber, obtaining spectral information from different sampling depths. The spectra were correlated with histopathology. A total of 76 spectra were obtained from tumor tissue and 110 spectra from healthy muscle tissue. The first- A nd second-order derivatives of the spectra were calculated and a classification algorithm was developed using fivefold cross validation with a linear support vector machine. The best results were obtained by the reflectance measured with a 1-mm source-detector distance (sensitivity, specificity, and accuracy are 89%, 82%, and 86%, respectively). DRS can accurately discriminate tumor from healthy tissue in an ex-vivo setting using a 1-mm source-detector distance. Accurate validation methods are warranted for larger sampling depths to allow for guidance during oral cavity cancer excision.</p
ΠΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ ΠΊΡΠΈΠΎΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°Π½ΡΠΎΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ Π³Π»ΠΈΡΠ΅ΡΠΈΠ½ ΠΈΠ»ΠΈ 1,2-ΠΏΡΠΎΠΏΠ°Π½Π΄ΠΈΠΎΠ», ΠΏΡΠΈ Π·Π°ΠΌΠΎΡΠ°ΠΆΠΈΠ²Π°Π½ΠΈΠΈ ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ²
ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»ΠΈ ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ², Π·Π°ΠΌΠΎΡΠΎΠΆΠ΅Π½Π½ΡΡ
Π² ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΊΡΠΈΠΎΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°Π½ΡΠ°Ρ
, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ½ΡΠ΅ Π½Π΅ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡΠΈΠ΅ (Π΄Π΅ΠΊΡΡΡΠ°Π½, ΠΏΠΎΠ»ΠΈΡΡΠΈΠ»Π΅Π½Π³Π»ΠΈΠΊΠΎΠ»Ρ) ΠΈ ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡΠΈΠ΅ (Π³Π»ΠΈΡΠ΅ΡΠΈΠ½, 1,2-ΠΏΡΠΎΠΏΠ°Π½Π΄ΠΈΠΎΠ») ΠΊΡΠΈΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΡ.
Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π² ΡΡΠΈΡΡΠΎΡΠΈΡΠ°Ρ
, Π·Π°ΠΌΠΎΡΠΎΠΆΠ΅Π½Π½ΡΡ
-ΠΎΡΠΎΠ³ΡΠ΅ΡΡΡ
Π² ΡΡΠ΅Π΄Π΅ Ρ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°ΠΌΠΈ, ΠΎΡΠΌΠ΅ΡΠ°Π΅ΡΡΡ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΡΠΊΠΎΡΠΎΡΡΠΈ ΠΏΠΎΡΠΎΠΊΠ°
ΠΈΠΎΠ½ΠΎΠ² Π+ ΠΈ ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠΉ Ρ
ΡΡΠΏΠΊΠΎΡΡΠΈ Π² ΡΡΠ΅Π΄Π΅, ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅ΠΉ 0,45β0,9% NaCl. ΠΠ»Ρ ΡΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΡ ΠΎΡΠΌΠΎΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ²ΠΎΠΉΡΡΠ² Π·Π°ΠΌΠΎΡΠΎΠΆΠ΅Π½Π½ΡΡ
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ΠΎΡΠΎΠ³ΡΠ΅ΡΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ Π²ΠΊΠ»ΡΡΠΈΡΡ Π² ΡΡΠ΅Π΄Ρ Π³Π»ΠΈΡΠ΅ΡΠΈΠ½ ΠΈΠ»ΠΈ 1,2-ΠΏΡΠΎΠΏΠ°Π½Π΄ΠΈΠΎΠ» (1,2-ΠΠ) Π² ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ 5%. ΠΠΎΠ»ΡΡΠ΅Π½Π½ΡΠ΅
ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΠΏΡΠ΅Π΄ΠΏΠΎΠ»ΠΎΠΆΠΈΡΡ, ΡΡΠΎ ΠΊΡΠΈΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠ½Π°Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΠΊΡΠΈΠΎΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°Π½ΡΠΎΠ², ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΡ
Π½Π΅ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡΠΈΠ΅ ΠΈ ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡΠΈΠ΅ ΠΊΡΠΈΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΡ, ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΡΡΡ Π²ΠΊΠ»Π°Π΄ΠΎΠΌ ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ
ΠΏΠΎ ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΡ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΊΡΠΈΠΎΠ·Π°ΡΠΈΡΠ½ΡΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² Π² ΡΡΠΌΠΌΠ°ΡΠ½ΡΡ Π·Π°ΡΠΈΡΠ½ΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΈ Π·Π°ΠΌΠΎΡΠ°ΠΆΠΈΠ²Π°Π½ΠΈΠΈ ΠΈ ΠΎΡΠ»Π°Π±Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΏΠΎΡΡΠ³ΠΈΠΏΠ΅ΡΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΡΠ΅ΡΡΠ° Π½Π°
ΠΊΠ»Π΅ΡΠΊΠΈ ΠΏΡΠΈ ΡΠ°Π·ΠΌΠΎΡΠ°ΠΆΠΈΠ²Π°Π½ΠΈΠΈ.ΠΠΎΡΠ»ΡΠ΄ΠΆΡΠ²Π°Π»ΠΈ ΠΎΡΠΌΠΎΡΠΈΡΠ½Ρ Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΡ Π΅ΡΠΈΡΡΠΎΡΠΈΡΡΠ², Π·Π°ΠΌΠΎΡΠΎΠΆΠ΅Π½ΠΈΡ
-Π²ΡΠ΄ΡΠ³ΡΡΡΠΈΡ
Ρ ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½ΠΈΡ
ΠΊΡΡΠΎΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°Π½ΡΠ°Ρ
, ΡΠΊΡ ΠΌΡΡΡΡΡΡ
ΠΏΠΎΠ»ΡΠΌΠ΅ΡΠ½Ρ Π½Π΅ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡΡ (Π΄Π΅ΠΊΡΡΡΠ°Π½, ΠΏΠΎΠ»ΡΠ΅ΡΠΈΠ»Π΅Π½Π³Π»ΡΠΊΠΎΠ»Ρ) Ρ ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡΡ (Π³Π»ΡΡΠ΅ΡΠΈΠ½, 1,2-ΠΏΡΠΎΠΏΠ°Π½Π΄ΡΠΎΠ») ΠΊΡΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠΈ. ΠΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ,
ΡΠΎ Π² Π΅ΡΠΈΡΡΠΎΡΠΈΡΠ°Ρ
, Π·Π°ΠΌΠΎΡΠΎΠΆΠ΅Π½ΠΈΡ
-Π²ΡΠ΄ΡΠ³ΡΡΡΠΈΡ
Ρ ΡΠ΅ΡΠ΅Π΄ΠΎΠ²ΠΈΡΡ Π· ΠΏΠΎΠ»ΡΠΌΠ΅ΡΠ°ΠΌΠΈ, Π²ΠΈΠ·Π½Π°ΡΠ°ΡΡΡΡΡ Π·ΡΠΎΡΡΠ°Π½Π½Ρ ΡΠ²ΠΈΠ΄ΠΊΠΎΡΡΡ ΠΏΠΎΡΠΎΠΊΡ ΡΠΎΠ½ΡΠ² Π+ Ρ
ΠΎΡΠΌΠΎΡΠΈΡΠ½ΠΎΡ ΠΊΡΠΈΡ
ΠΊΠΎΡΡΡ Π² ΡΠ΅ΡΠ΅Π΄ΠΎΠ²ΠΈΡΡ, ΡΠΊΠ΅ ΠΌΡΡΡΠΈΡΡ 0,45β0,9% NaCl. ΠΠ»Ρ Π·Π±Π΅ΡΠ΅ΠΆΠ΅Π½Π½Ρ ΠΎΡΠΌΠΎΡΠΈΡΠ½ΠΈΡ
Π²Π»Π°ΡΡΠΈΠ²ΠΎΡΡΠ΅ΠΉ Π·Π°ΠΌΠΎΡΠΎΠΆΠ΅Π½ΠΈΡ
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Π²ΡΠ΄ΡΠ³ΡΡΡΠΈΡ
ΠΊΠ»ΡΡΠΈΠ½ Π΄ΠΎΡΡΠ°ΡΠ½ΡΠΎ Π²ΠΊΠ»ΡΡΠΈΡΠΈ Π² ΡΠ΅ΡΠ΅Π΄ΠΎΠ²ΠΈΡΠ΅ Π³Π»ΡΡΠ΅ΡΠΈΠ½ Π°Π±ΠΎ 1,2-ΠΏΡΠΎΠΏΠ°Π½Π΄ΡΠΎΠ» Π² ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΡΡ 5%. ΠΡΡΠΈΠΌΠ°Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΈ
Π΄ΠΎΠ·Π²ΠΎΠ»ΡΡΡΡ ΠΏΡΠΈΠΏΡΡΡΠΈΡΠΈ, ΡΠΎ ΠΊΡΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠ½Π° Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΊΠΎΠΌΠ±ΡΠ½ΠΎΠ²Π°Π½ΠΈΡ
ΠΊΡΡΠΎΠΊΠΎΠ½ΡΠ΅ΡΠ²Π°Π½ΡΡΠ², ΡΠΊΡ ΠΌΡΡΡΡΡΡ Π½Π΅ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡΡ Ρ
ΠΏΡΠΎΠ½ΠΈΠΊΠ°ΡΡΡ ΠΊΡΡΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠΈ, Π²ΠΈΠ·Π½Π°ΡΠ°ΡΡΡΡΡ Π²Π½Π΅ΡΠΊΠΎΠΌ ΡΡΠ·Π½ΠΎΠΌΠ°Π½ΡΡΠ½ΠΈΡ
Π·Π° ΠΌΠ΅Ρ
Π°Π½ΡΠ·ΠΌΠΎΠΌ Π΄ΡΡ ΠΊΡΡΠΎΠ·Π°Ρ
ΠΈΡΠ½ΠΈΡ
ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΡΠ² Ρ ΡΡΠΌΠ°ΡΠ½Ρ Π·Π°Ρ
ΠΈΡΠ½Ρ
Π΅ΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡΡΡ ΠΏΡΠΈ Π·Π°ΠΌΠΎΡΠΎΠΆΡΠ²Π°Π½Π½Ρ ΡΠ° ΠΏΠΎΡΠ»Π°Π±Π»Π΅Π½Π½ΡΠΌ ΠΏΠΎΡΡΠ³ΡΠΏΠ΅ΡΡΠΎΠ½ΡΡΠ½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΡΡ Π½Π° ΠΊΠ»ΡΡΠΈΠ½ΠΈ ΠΏΡΠΈ ΡΠΎΠ·ΠΌΠΎΡΠΎΠΆΡΠ²Π°Π½Π½Ρ.The osmotic properties of erythrocytes frozen-thawed in combined cryopreservatives, containing polymeric non-penetrating
(dextran, polyethylene glycol) and penetrating (glycerol, 1,2-propane diol) cryoprotectants were studied. It was established that in
erythrocytes frozen-thawed in the presence of polymers the increasing of H+ ion flow rate and osmotic fragility in the environment
with 0.45β0.9% NaCl was observed. It is sufficient to add 5% glycerol or 1,2-propane diol (1,2-PD) to the medium to preserve
osmotic properties of frozen-thawed cells. The obtained results enable to suggest that cryoprotective efficiency of combined
cryopreservatives, containing non-penetrating and penetrating cryoprotectants is determined both by the contribution of cryoprotective
components differing by action mechanism into th
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