17 research outputs found
STUDY OF LIQUID NICKEL-VANADIUM ALLOYS BY NEUTRON DIFFRACTION AND MODEL SIMULATION
No abstract availabl
Multiscale modelling of plastic deformation
In order to describe the plastic behavior of crystalline materials containing structural heterogeneities and/or under complex loadings, a new non local method that incorporates both dislocation properties and a rigorous treatment of boundary value problems is proposed. This new computer model makes use of a coupling between two different types of three-dimensional simulations : a Finite Elements code and a simulation of dislocation dynamics at the mesoscopic scale. The simulation technique is briefly presented and is illustrated by preliminary tests on the plastic deformation of copper single crystals at small strains
A narrative review of the impact of disbelief in chronic pain
Although the experience of being believed is frequently alluded to in chronic pain literature, few studies have specifically explored this phenomenon and even fewer reviews have been offered. This narrative review sought to explore the wider social context in which individuals with chronic pain may experience disbelief toward their pain. Articles were obtained through a search of eight databases and a hand search of the references of full-text papers. Key results within the articles were noted and integrated to form three main themes: stigma, the experience of isolation, and the experience of emotional distress. The experience of stigma can occur in a number of ways. It may be through actual or perceived encounters with others; it can be through the use of psychologic explanations of pain; it can come through a perceived challenge to one's integrity and subsequently affect an individual's identity; and such stigma may be influenced by negative female stereotypes. The loss of relationships associated with being disbelieved can lead to the experience of isolation. This may be self-initiated, particularly when an individual has been given a contested diagnosis. Finally, disbelief can lead to emotional distress. This can take the form of guilt, depression, and anger. Throughout the article, implications for health care professionals, working with individuals living with chronic pain, are discussed. © 2013 American Society for Pain Management Nursing
Scheduling analysis principles and tool for time and space partitioned systems
International audienc
Comparison of the clinical prediction model PREMM1,2,6 and molecular testing for the systematic identification of Lynch syndrome in colorectal cancer
Background Lynch syndrome is caused by germline
mismatch repair (MMR) gene mutations. The
PREMM1,2,6 model predicts the likelihood of a MMR
gene mutation based on personal and family cancer
history.
Objective To compare strategies using PREMM1,2,6 and
tumour testing (microsatellite instability (MSI) and/or
immunohistochemistry (IHC) staining) to identify
mutation carriers.
Design Data from population-based or clinic-based
patients with colorectal cancers enrolled through the
Colon Cancer Family Registry were analysed. Evaluation
included MSI, IHC and germline mutation analysis for
MLH1, MSH2, MSH6 and PMS2. Personal and family
cancer histories were used to calculate PREMM1,2,6
predictions. Discriminative ability to identify carriers from
non-carriers using the area under the receiver operating
characteristic curve (AUC) was assessed. Predictions
were based on logistic regression models for (1) cancer
assessment using PREMM1,2,6, (2) MSI, (3) IHC for
loss of any MMR protein expression, (4) MSI+IHC,
(5) PREMM1,2,6+MSI, (6) PREMM1,2,6+IHC,
(7) PREMM1,2,6+IHC+MSI.
Results Among 1651 subjects, 239 (14%) had
mutations (90 MLH1, 125 MSH2, 24 MSH6).
PREMM1,2,6 discriminated well with AUC 0.90 (95% CI
0.88 to 0.92). MSI alone, IHC alone, or MSI+IHC each
had lower AUCs: 0.77, 0.82 and 0.82, respectively. The
added value of IHC+PREMM1,2,6 was slightly greater
than PREMM1,2,6+MSI (AUC 0.94 vs 0.93). Adding MSI
to PREMM1,2,6+IHC did not improve discrimination.
Conclusion PREMM1,2,6 and IHC showed excellent
performance in distinguishing mutation carriers from noncarriers and performed best when combined. MSI may
have a greater role in distinguishing Lynch syndrome
from other familial colorectal cancer subtypes among
cases with high PREMM1,2,6 scores where genetic
evaluation does not disclose a MMR mutation