The position of graptolites within Lower Palaeozoic planktic ecosystems.

An integrated approach has been used to assess the palaeoecology of graptolites both as a discrete group and also as a part of the biota present within Ordovician and Silurian planktic realms. Study of the functional morphology of graptolites and comparisons with recent ecological analogues demonstrates that graptolites most probably filled a variety of niches as primary consumers, with modes of life related to the colony morphotype. Graptolite coloniality was extremely ordered, lacking any close morphological analogues in Recent faunas. To obtain maximum functional efficiency, graptolites would have needed varying degrees of coordinated automobility. A change in lifestyle related to ontogenetic changes was prevalent within many graptolite groups. Differing lifestyle was reflected by differing reproductive strategies, with synrhabdosomes most likely being a method for rapid asexual reproduction. Direct evidence in the form of graptolithophage 'coprolitic' bodies, as well as indirect evidence in the form of probable defensive adaptations, indicate that graptolites comprised a food item for a variety of predators. Graptolites were also hosts to a variety of parasitic organisms and provided an important nutrient source for scavenging organisms

Discovery of 505-million-year old chitin in the basal demosponge Vauxia gracilenta

Sponges are probably the earliest branching animals, and their fossil record dates back to the Precambrian. Identifying their skeletal structure and composition is thus a crucial step in improving our understanding of the early evolution of metazoans. Here, we present the discovery of 505-million-year-old chitin, found in exceptionally well preserved Vauxia gracilenta sponges from the Middle Cambrian Burgess Shale. Our new findings indicate that, given the right fossilization conditions, chitin is stable for much longer than previously suspected. The preservation of chitin in these fossils opens new avenues for research into other ancient fossil groups

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Productivity performance of climatological sub-regions within the Tully mill area

Inter-annual climate variability has a significant impact on productivity in the Wet Tropics region. Climate also varies spatially, yet the impact on productivity is less well known. Two distinct climatological sub-regions (northern and southern) have been identified within the Tully mill area based on total annual rainfall and annual average daily radiation. The wetter northern sub-region is characterised by lower radiation, lower temperatures and higher rainfall than in the drier southern sub-region. Mean cane and sugar yields were analysed for the two climate sub-regions using block productivity data obtained from Tully Sugar Limited for 2000 to 2017. After excluding 2011 (Tropical Cyclone Yasi), only farms with 15 or more years of data were included. The impact of spring-summer (SONDJF) rainfall and El Niño Southern Oscillation (ENSO) phases on cane and sugar yields in the two climate sub-regions was also analysed. On average, the northern, wetter climate sub-region yielded less cane and sugar yield than the southern, drier sub-region. There were significant differences between SONDJF rainfall terciles (dry, normal and wet) and ENSO phases (El Niño, Neutral and La Niña) for cane and sugar yields in the two climate sub-regions. Cane and sugar yields were significantly lower in years experiencing high SONDJF rainfall or in the La Niña phase. This analysis validates the results of the analyses used to derive the two climatological sub-regions in Tully. Improved knowledge of how climatic conditions influence sub-regional productivity performance will assist industry extension programs and on-farm management decisions