14 research outputs found
Images in neuroscience. The slow and clumsy motor cyclist.
No full textJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia148757, 810
The in vivo and in vitro effect of inhibitors of brd4 and cdk9 on early phase of post traumatic osteoarthritis
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Comprehensive transcriptome analysis of aging-related gene expression in early phase of post-traumatic osteoarthritis
No full textCDK9 inhibition attenuates inflammatory response and apoptosis in cartilage explants to preserve matrix integrity in a single impact mechanical injury model
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Linking green micro-breaks with mood and performance: Mediating roles of coherence and effort
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Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology
No full text10.1002/gepi.21886Genetic Epidemiology393207-21
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma
No full textElevated intraocular pressure (IOP) is an important risk factor in developing glaucoma, and variability in IOP might herald glaucomatous development or progression. We report the results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP. We confirm genetic association of known loci for IOP and primary open-angle glaucoma (POAG) and identify four new IOP-associated loci located on chromosome 3q25.31 within the FNDC3B gene (P = 4.19 × 10 '8 for rs6445055), two on chromosome 9 (P = 2.80 × 10 '11 for rs2472493 near ABCA1 and P = 6.39 × 10 '11 for rs8176693 within ABO) and one on chromosome 11p11.2 (best P = 1.04 × 10 '11 for rs747782). Separate meta-analyses of 4 independent POAG cohorts, totaling 4,284 cases and 95,560 controls, showed that 3 of these loci for IOP were also associated with POAG
