A (Running) Bolt for New Reasons

We construct a four-parameter family of smooth, horizonless, stationary solutions of ungauged five-dimensional supergravity by using the four-dimensional Euclidean Schwarzschild metric as a base space and "magnetizing" its bolt. We then generalize this to a five-parameter family based upon the Euclidean Kerr-Taub-Bolt. These "running Bolt" solutions are necessarily non-static. They also have the same charges and mass as a non-extremal black hole with a classically-large horizon area. Moreover, in a certain regime their mass can decrease as their charges increase. The existence of these solutions supports the idea that the singularities of non-extremal black holes are resolved by low-mass modes that correct the singularity of the classical black hole solution on large (horizon-sized) scales.Comment: 25 pages, 3 figures, LaTeX; v2: minor changes, references adde

Multi-Center non-BPS Black Holes - the Solution

We construct multi-center, non-supersymmetric four-dimensional solutions describing a rotating anti-D6-D2 black hole and an arbitrary number of D4-D2-D0 black holes in a line. These solutions correspond to an arbitrary number of extremal non-BPS black rings in a Taub-NUT space with a rotating three-charge black hole in the middle. The positions of the centers are determined by solving a set of "bubble" or "integrability" equations that contain cubic polynomials of the inter-center distance, and that allow scaling solutions even when the total four-dimensional angular momentum of the scaling centers is non-zero.Comment: 16 pages, LaTe

Q-ball scattering on barriers and holes in 1 and 2 Spatial dimensions

We discuss various scattering properties of non-topological solitons, Q-balls, on potential obstructions in (1+1) and (2+1) dimensions. These obstructions, barriers and holes, are inserted into the potential of the theory via the coupling parameter, ie \tilde\lambda, that is effective only in a certain region of space. When \tilde\lambda > 1 the obstruction is a barrier and when 0 < \tilde\lambda < 1 the obstruction is a hole. The dynamics of Q-balls on such obstructions in (1+1) dimensions is shown to be very similar to that of topological solitons provided that the Q-balls are stable. In (2+1) dimensions, numerical simulations have shown some differences from the dynamics of topological solitons. We discuss these differences in some detail.Comment: 26 pages, 22 figure

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale. Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation; analyses timings and patterns of tumour evolution; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity; and evaluates a range of more-specialized features of cancer genomes