Fatty acid oxidation in skeletal and cardiac muscle

Contains fulltext : mmubn000001_02755757x.pdf (publisher's version ) (Open Access)Promotores : J. Veerkamp en S. Bontingxii, 195 p

Added value of H-FABP as plasma biomarker for the early evaluation of suspected acute coronary syndrome

Suspected acute coronary syndrome (ACS) represents a substantial healthcare problem and is responsible for a large proportion of emergency department admissions. Better triaging of patients with suspected ACS is needed to facilitate early initiation of appropriate therapy in patients with acute myocardial infarction (AMI) and to exclude low-risk patients who can safely be sent home, thereby limiting healthcare costs. H-FABP has been established as the earliest available plasma marker for myocardial injury. In this review we evaluate the clinical utility of H-FABP for suspected ACS. H-FABP shows added value in addition to cardiac troponin, especially in the early hours after onset of symptoms. Moreover, H-FABP identifies patients at increased risk for future cardiac events. It is concluded that measuring H-FABP along with troponin shortly after onset of symptoms improves risk stratification of patients suspected of having ACS in a cost-effective manner. © 2014 Future Medicine Ltd

Changes in the triglyceride-rich lipoproteins and the response to dietary cholesterol in man.

The effect of a cholesterol-enriched diet was studied in nine healthy volunteers with special emphasis to the changes which occurred in the triglyceride-rich lipoproteins (d<1.019 g/ml). Compared to the habitual diet, a moderately increased intake of cholesterol (from 300–900 mg/day) resulted in changes of the lipid composition and in a decrease of the apoprotein bands apo B-100, C and E of the d<1.019 g/ml fraction by 25–30%. On the average, the intensity of the apo B-48 band increased. The most consistent was a decrease of cholesterol and triglycerides in the d<1.019 g/ml fraction binding to heparin-Sepharose considered to represent remnants of very low-density lipoproteins. Low-density lipoprotein cholesterol increased by 0.2 mmol/l (ns). However, three subjects with relatively low concentrations of lipids and apoproteins in the d<1.019 g/ml fraction showed a hyperresponse of LDL-cholesterol by more than 0.5 mmol/l. In these subjects the intensity of the B-48 band did not increase on the cholesterol-enriched diet. The results suggest, that the rise in LDL-cholesterol caused by dietary cholesterol is mediated by an enhanced uptake of chylomicron- and VLDL-remnants by the liver, followed by a secondary down-regulation of the LDL-receptors

Histochemical localization of heart-type fatty-acid binding protein in human and murine tissues

Contains fulltext : 22186___.PDF (publisher's version ) (Open Access