Subglacial Water Flow Over an Antarctic Palaeo‐Ice Stream Bed

The subglacial hydrological system exerts a critical control on the dynamic behavior of the overlying ice because its configuration affects the degree of basal lubrication between the ice and the bed. Yet, this component of the glaciological system is notoriously hard to access and observe, particularly over timescales longer than the satellite era. In Antarctica, abundant evidence for past subglacial water flow over former ice-sheet beds exists around the peripheries of the ice sheet including networks of huge channels carved into bedrock (now submarine) on the Pacific margin of West Antarctica. Here, we combine detailed bathymetric investigations of a channel system in Marguerite Trough, a major palaeo-ice stream bed, with numerical hydrological modeling to explore subglacial water accumulation, routing and potential for erosion over decadal-centennial timescales. Detailed channel morphologies from remotely operated vehicle surveys indicate multiple stages of localized incision, and the occurrence of potholes, some gigantic in scale, suggests incision by turbulent water carrying a significant bedload. Further, the modeling indicates that subglacial water is available during deglaciation and was likely released in episodic drainage events, from subglacial lakes, varying in magnitude over time. Our observations support previous assertions that these huge bedrock channel systems were incised over multiple glacial cycles through episodic subglacial lake drainage events; however, here we present a viable pattern for subglacial drainage at times when the ice sheet existed over the continental shelf and was capable of continuing to erode the bedrock substrate

A long-term mass-balance reconstruction (1974–2021) and a decadal in situ mass-balance record (2011–2021) of Rikha Samba Glacier, central Himalaya

Despite their importance for regional water resource planning and as indicators of climate change, records of in situ glacier mass balance remain short and spatially sparse in the Himalaya. Here, we present an updated series of in situ mass-balance measurements from Rikha Samba Glacier, Nepal, between 2011 and 2021. The updated in situ mass balance is -0.39 +/- 0.32 m w.e. for this period. We use an energy-mass balance model to extend the annual mass-balance series back to 1974. The model is forced using daily meteorological variables from ERA5-Land reanalysis data that is linearly bias-corrected using observations from an automatic weather station situated near the glacier terminus. The modeled mass balance is consistent with the in situ mass-balance series measured 2011-2021 and with previous glaciological and geodetic estimates. The model results indicate a mass balance of -0.56 +/- 0.27 m w.e. a(-1) over the reconstruction period of 1974-2021, which is comparable to the mass losses experienced by other Himalayan glaciers during this time. An assessment of the sensitivity of the glacier mass balance to meteorological forcing suggests that a change in temperature of +/- 1 K has a stronger effect on the calculated mass balance compared to a +/- 20% change in either precipitation, or relative humidity, or solar radiation

Plant closure in multiplant firms A geographical perspective

SIGLEAvailable from British Library Document Supply Centre-DSC:DX210368 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Differential contributions of set-shifting and monitoring to dual-task interference

It is commonly argued that complex behaviour is regulated by a number of “executive functions” which work to co-ordinate the operation of disparate cognitive systems in the service of an overall goal. However, the identity, roles, and interactions of specific putative executive functions remain contentious, even within widely accepted tests of executive function. The authors present two experiments that use dual-task interference to provide further support for multiple distinct executive functions and to establish the differential contributions of those functions in two relatively complex executive tasks – Random Generation and the Wisconsin Card Sorting Test. Results are interpreted in terms of process models of the complex executive tasks

Nasal Delivery of a Commensal Pasteurellaceae Species Inhibits Nontypeable Haemophilus influenzae Colonization and Delays Onset of Otitis Media in Mice.

Contains fulltext : 218895.pdf (Publisher’s version ) (Open Access)Nasopharyngeal colonization with nontypeable Haemophilus influenzae (NTHi) is a prerequisite for developing NTHi-associated infections, including otitis media. Therapies that block NTHi colonization may prevent disease development. We previously demonstrated that Haemophilus haemolyticus, a closely related human commensal, can inhibit NTHi colonization and infection of human respiratory epithelium in vitro We have now assessed whether Muribacter muris (a rodent commensal from the same family) can prevent NTHi colonization and disease in vivo using a murine NTHi otitis media model. Otitis media was modeled in BALB/c mice using coinfection with 1 x 10(4.5) PFU of influenza A virus MEM H3N2, followed by intranasal challenge with 5 x 10(7) CFU of NTHi R2866 Spec(r) Mice were pretreated or not with an intranasal inoculation of 5 x 10(7) CFU M. muris 24 h before coinfection. NTHi and M. muris viable counts and inflammatory mediators (gamma interferon [IFN-gamma], interleukin-1beta [IL-1beta], IL-6, keratinocyte chemoattractant [KC], and IL-10) were measured in nasal washes and middle ear tissue homogenate. M. muris pretreatment decreased the median colonization density of NTHi from 6 x 10(5) CFU/ml to 9 x 10(3) CFU/ml (P = 0.0004). Only 1/12 M. muris-pretreated mice developed otitis media on day 5 compared to 8/15 mice with no pretreatment (8% versus 53%, P = 0.0192). Inflammation, clinical score, and weight loss were also lower in M. muris-pretreated mice. We have demonstrated that a single dose of a closely related commensal can delay onset of NTHi otitis media in vivo Human challenge studies investigating prevention of NTHi colonization are warranted to reduce the global burden of otitis media and other NTHi diseases