Magnetization Process of High Anisotropy Copt Nanosized Dots

The magnetization reversal process of the CoPt dot was investigated in this paper. It was observed that the magnetization reversal of the dot was initiated by the rotation process of a nucleus with the volume of (17 nm)/sup 3/

An abridged Spanish version of Sexual Double Standard Scale: Factorial structure, reliability and validity evidence

Background/Objective Sexual double standard (SDS) has long been associated to several dimensions of sexual health. Therefore the assessment of SDS is relevant and requires self-reported measures with adequate psychometric properties. This study aims to adapt the Sexual Double Standard Scale (SDSS) into heterosexual Spanish population and examine its psychometric properties. Method: Using quota incidental sampling, we recruited a sample of 1, 206 individuals (50% women), distributed across three groups based on their age (18-34, 35-49 and 50 years old and older). Results: We performed both, Exploratory Factor Analysis and Confirmatory Factor Analysis. An abridged version was yielded, consisting of 16 items distributed into two factors (Acceptance for sexual freedom and Acceptance for sexual shyness). A second-order factor structure was also adequate, which facilitates the use of a global index for SDS. Reliability, based on internal consistency and temporal stability was good for the factors. Evidence of validity is also shown and reported. Conclusions: This adapted version of the SDSS is reliable and valid. The importance for its use to estimate the prevalence of both traditional and modern forms of this phenomenon is discussed. Antecedentes/Objetivo: El doble estándar sexual (DES) se ha asociado a distintas dimensiones de la salud sexual, por lo que su evaluación es relevante y requiere de instrumentos con ade- cuadas propiedades psicométricas. Se plantea la adaptación a población heterosexual espa ~ nola de la Sexual Double Standard Scale (SDSS) y examinar sus propiedades psicométricas. Método : Mediante un muestreo incidental por cuotas se obtuvo una muestra de 1.206 sujetos (50% mujeres), distribuidos en tres grupos en función de la edad (18-34 a ~ nos, 35-49 a ~ nos y 50 a ~ nos o más). Resultados : Mediante Análisis Factorial Exploratorio y Análisis Factorial Confirmatorio se consiguió una versión de 16 ítems distribuidos en dos factores (Aceptación de la libertad sexual y Aceptación del recato sexual), cuya combinación en un factor de segundo orden per- mite obtener un índice global de doble estándar sexual. La fiabilidad de consistencia interna y test-retest es óptima para los dos subfactores y sus medidas presentan adecuados índices de validez. Conclusiones : Esta versión adaptada de la SDSS es fiable y válida. Se discute su impor- tancia para detectar la prevalencia de DES tradicional y de expresiones más modernas de este fenómeno

Statistics of finite-time Lyapunov exponents in the Ulam map

The statistical properties of finite-time Lyapunov exponents at the Ulam point of the logistic map are investigated. The exact analytical expression for the autocorrelation function of one-step Lyapunov exponents is obtained, allowing the calculation of the variance of exponents computed over time intervals of length $n$. The variance anomalously decays as $1/n^2$. The probability density of finite-time exponents noticeably deviates from the Gaussian shape, decaying with exponential tails and presenting $2^{n-1}$ spikes that narrow and accumulate close to the mean value with increasing $n$. The asymptotic expression for this probability distribution function is derived. It provides an adequate smooth approximation to describe numerical histograms built for not too small $n$, where the finiteness of bin size trimmes the sharp peaks.Comment: 6 pages, 4 figures, to appear in Phys. Rev.

Historical and ecological drivers of the spatial pattern of Chondrichthyes species richness in the Mediterranean Sea

Chondrichthyes, which include Elasmobranchii (sharks and batoids) and Holocephali (chimaeras), are a relatively small group in the Mediterranean Sea (89 species) playing a key role in the ecosystems where they are found. At present, many species of this group are threatened as a result of anthropogenic effects, including fishing activity. Knowledge of the spatial distribution of these species is of great importance to understand their ecological role and for the efficient management of their populations, particularly if affected by fisheries. This study aims to analyze the spatial patterns of the distribution of Chondrichthyes species richness in the Mediterranean Sea. Information provided by the studied countries was used to model geographical and ecological variables affecting the Chondrichthyes species richness. The species were distributed in 16 Operational Geographical Units (OGUs), derived from the Geographical Sub-Areas (GSA) adopted by the General Fisheries Commission of the Mediterranean Sea (GFCM). Regression analyses with the species richness as a target variable were adjusted with a set of environmental and geographical variables, being the model that links richness of Chondrichthyes species with distance to the Strait of Gibraltar and number of taxonomic families of bony fishes the one that best explains it. This suggests that both historical and ecological factors affect the current distribution of Chondrichthyes within the Mediterranean Sea.Postprin

Variaciones interanuales en las capturas de tiburones pelágicos en el

Pelagic migrating sharks are by-caught incidentally in longline fisheries. Some of these species have been catalogued as threatened or vulnerable by several Regional Fisheries Organizations and International Conservational NGOs. Alboran Sea is an important area for pelagic migrating sharks because it is the natural and unique communication way between the Atlantic Ocean and Mediterranean Sea. This area is considered by several authors as a hot-spot of Climate Oscillation, such as the North Atlantic Oscillation (NAO) and the Arctic Oscillation (AO). In addition, Alboran Sea is an important fishing ground where the longline fisheries targeting swordfish operates. Recent studies concluded that historical landing of pelagic sharks from harbours of Alboran Sea and Balearic Sea were mediated for atmospheric oscillations. The main aim of the present study was to assess the effect of atmospheric oscillation on the Catch per Unit Effort (CPUE) of vulnerable sharks thresher shark, Alopias vulpinus (Bonnaterre, 1788) and shortfin mako, Isurus oxyrinchus (Rafinesque, 1810) by-caught in the traditional longline fisheries. The atmospheric oscillations tested in this study were the North Atlantic Oscillation (NAO) and the Arctic Oscillation (AO). We found a significant positive correlation between the NAO and AO indexes of the previous year to the CPUE tested.En prens

Neuropathological findings in fatal COVID-19 and their associated neurological clinical manifestations

9 p.Severe cases of Coronavirus Disease 2019 (COVID-19) can present with multiple neurological symptoms. The available neuropathological studies have described different lesions; the most frequent was the presence of neuroinflammation and vascular-related lesions. The objective of this study was to report the neuropathological studies performed in a medical institution, with abundant long intensive care unit stays, and their associated clinical manifestations. This is a retrospective monocentric case series study based on the neuropathological reports of 13 autopsies with a wide range of illness duration (13-108 days). A neuroinflammatory score was calculated based on the quantification of CD8- and CD68-positive cells in representative areas of the central nervous system. This score was correlated afterwards with illness duration and parameters related to systemic inflammation. Widespread microglial and cytotoxic T-cell activation was found in all patients. There was no correlation between the neuroinflammatory score and the duration of the illness; nor with parameters of systemic inflammation such as the peak of IL-6 or the HScore (a parameter of systemic macrophage activation syndrome). Two patients had global hypoxic ischaemic damage and five patients had subacute infarcts. One patient had many more brain vascular microthrombi compared to the others and multiple subacute pituitary infarcts. SARS-CoV-2 RNA was not detected with qRT-PCR. The proportion of brain lesions in severe COVID-19 patients could be related to illness duration. In our series, with abundant long hospitalisation stays, neuroinflammation was present in all patients and was more prominent between day 34 and day 45 after onset of symptoms. Clinical correlation showed that two patients with the highest neuroinflammatory scores had severe encephalopathies that were not attributable to any other cause. The second most frequent lesions were related to vascular pathology.Instituto de Salud Carlos IIICIBERONCInstituto Ramón y Cajal de Investigación SanitariaMerck, Sharp & Dohme (MSD

Análisis preliminar del efecto de las oscilaciones climáticas sobre la condición física de la melva (Auxis rochei) post-reproductora en el Mar de Alborán

The Mediterranean Sea is considered by several authors as a hot-spot of Climate Oscillation, such as the North Atlantic Oscillation (NAO) and the Arctic Oscillation (AO). However, information about the effect of the climate oscillations on the fitness of the species is still scarce. In this context, bullet tuna is an important migratory species with a substantial socio-economical value, whose fisheries might be affected by the effect of certain climatological conditions. In fact, these atmospheric oscillations trigger a chain of hydrodynamic events, leading a change on the timing, destinations, and success of the migratory species in their search for spawning grounds. This study relies on the hypothesis of a correlation between the physical condition of the post-spawning bullet tuna and climate oscillation indexes. For that purpose, 151 individuals of bullet tuna, Auxis rochei, were collected in the traps of Ceuta (Alboran Sea) during three different years, (1983, 1984 and 2014). The physical condition index was calculated, and later statistically correlated with the climate oscillation indexes proposed. Significant differences were found between the physical condition of A. rochei and the average accumulated NAO index. Moreover, for age class 3+ we obtained a significant correlation with atmospheric oscillations.Postprin

Segregación espacial por sexo de la tintorera en el Atlántico Este y

The main aim of present study was to analyze the spatial and temporal trends segregation by sex of blue shark (Prionace glauca) in the Eastern Atlantic and Western Mediterranean Sea from the individual bycatches by Spanish surface longline fleet. Our results indicate significant differences in the use of space between males and females. Thus, in low latitudes, within the observed range, sharks are mixed, but from North 38 degree of latitude tend to segregate. In the case of length, a similar pattern is observed, in low longitude sexes appear overlapped, and while to high longitude tend to appear segregated. All these results suggested segregation by sex in the Mediterranean where sharks are grouped in single-sex schools.Postprin

Predicting Survival after Allogeneic Hematopoietic Cell Transplantation in Myelofibrosis : Performance of the Myelofibrosis Transplant Scoring System (MTSS) and Development of a New Prognostic Model

Accurate prognostic tools are crucial to assess the risk/benefit ratio of allogeneic hematopoietic cell transplantation (allo-HCT) in patients with myelofibrosis (MF). We aimed to evaluate the performance of the Myelofibrosis Transplant Scoring System (MTSS) and identify risk factors for survival in a multicenter series of 197 patients with MF undergoing allo-HCT. After a median follow-up of 3.1 years, 47% of patients had died, and the estimated 5-year survival rate was 51%. Projected 5-year risk of nonrelapse mortality and relapse incidence was 30% and 20%, respectively. Factors independently associated with increased mortality were a hematopoietic cell transplantation-specific comorbidity index (HCT-CI) ≥3 and receiving a graft from an HLA-mismatched unrelated donor or cord blood, whereas post-transplant cyclophosphamide (PT-Cy) was associated with improved survival. Donor type was the only parameter included in the MTSS model with independent prognostic value for survival. According to the MTSS, 3-year survival was 62%, 66%, 37%, and 17% for low-, intermediate-, high-, and very high-risk groups, respectively. By pooling together the low- and intermediate-risk groups, as well as the high- and very high-risk groups, we pinpointed 2 categories: standard risk and high risk (25% of the series). Three-year survival was 62% in standard-risk and 25% in high-risk categories (P <.001). We derived a risk score based on the 3 independent risk factors for survival in our series (donor type, HCT-CI, and PT-Cy). The corresponding 5-year survival for the low-, intermediate-, and high-risk categories was 79%, 55%, and 32%, respectively (P <.001). In conclusion, the MTSS model failed to clearly delineate 4 prognostic groups in our series but may still be useful to identify a subset of patients with poor outcome. We provide a simple prognostic scoring system for risk/benefit considerations before transplantation in patients with MF

Implante hematopoyético de una serie de pacientes movilizados con Plerixafor. Estudio retrospectivo multicéntrico

Poster [PC-256] Introducción: Plerixafor (PLX) es un inhibidor del receptor CXCR4 de probada eficacia en la recolección de PHSP para autotrasplante hematopoyético (TASPE) en pacientes malos movilizadores. Los estudios llevados a cabo hasta la fecha se han centrado mayoritariamente en aspectos referentes a la cinética de movilización (Mx) y rendimiento. El objetivo de nuestro estudio es recoger una amplia experiencia multicéntrica sobre el injerto hematopoyético a corto y medio plazo de pacientes que habían sido movilizados con PLX. Paciente: s y Métodos: Estudiamos retrospectivamente todos los pacientes que recibieron PLX como parte del esquema de movilización de PHSP para TASPE durante los años 2008-18 en siete hospitales de la zona norte; las enfermedades de base fueron: 94 linfomas no Hogdkin, 14 con enfermedad de Hogdkin, 78 mieloma múltiple y 4 con otros diagnósticos. 108 pacientes eran varones (56%) y 82 mujeres (44%). Su edad mediana era 59 años (4-73). Su peso y su altura oscilaron entre 15-134 kg y 106-188 cm, respectivamente. La mediana de líneas de tratamiento de nuestra serie fue de 2 (1-5); veintiún pacientes habían recibido radioterapia extensa y 15 pacientes uno o varios TASPEs previos. El número de intentos de Mx previos osciló entre 0 y 4 (mediana: 1). La pauta de G-CSF empleada fue de 5-10 mcg/kg/12 h durante 1-14 días (mediana: 6 días) y la dosis de PLX fue la recomendada en ficha técnica (0.24mcg/Kg/24horas). En 36 casos (18, 95%) la movilización se realizó en la fase de recuperación tras un ciclo de la quimioterapia de tratamiento. Tabla 1. Características de la serie y empleo de PLX. Resultados: se realizaron un total de 159 TASPEs. El estatus de la hemopatía en el momento del trasplante era remisión completa en el 50% de los casos. En cuanto a los resultados de movilización y colecta, la mediana de sesiones de aféresis requeridas fue de 2, rango (0-5) y la cifra de células CD34+ recolectada fue de 2, 79 (x 106/kg) con un rango entre 0 y 30, 3. Tabla 2. Datos de implante a corto y medio plazo Conclusiones: 1) el empleo de Plerixafor permitió realizar el TASPE en un alto porcentaje de pacientes malos movilizadores; 2) la calidad del injerto a corto y medio plazo de los pacientes autotrasplantados movilizados con PLX fue óptimo en la gran mayoría de los casos; 3) en nuestro conocimiento, esta serie multicéntrica es una de las mayores comunicadas enfocada en la calidad del implante a corto y medio plazo de pacientes malos movilizadores sometidos a TASPE