71 research outputs found
Domestic Violence and Health Care: Opening Pandora¿s Box ¿ Challenges and Dilemmas
In this article we take a critical stance toward the rational progressive narrative
surrounding the integration of domestic violence within health care. Whilst changes in
recent UK policy and practice have resulted in several tangible benefits, it is argued that
there may be hidden dilemmas and challenges. We suggest that the medical model of care
and its discursive practices position women as individually accountable for domestic
violence-related symptoms and injuries. This may not only be ineffective in terms of
service provision but could also have the potential to reduce the political significance of
domestic violence as an issue of concern for all women. Furthermore, it is argued that the
use of specific metaphors enables practitioners to distance themselves from interactions
that may prove to be less comfortable and provide less than certain outcomes. Our analysis
explores the possibilities for change that might currently be available. This would
appear to involve a consideration of alternative discourses and the reformulation of power
relations and subject positions in health care
Detectable clonal mosaicism and its relationship to aging and cancer
In an analysis of 31,717 cancer cases and 26,136 cancer-free controls from 13 genome-wide association studies, we observed large chromosomal abnormalities in a subset of clones in DNA obtained from blood or buccal samples. We observed mosaic abnormalities, either aneuploidy or copy-neutral loss of heterozygosity, of >2 Mb in size in autosomes of 517 individuals (0.89%), with abnormal cell proportions of between 7% and 95%. In cancer-free individuals, frequency increased with age, from 0.23% under 50 years to 1.91% between 75 and 79 years (P = 4.8 × 10(-8)). Mosaic abnormalities were more frequent in individuals with solid tumors (0.97% versus 0.74% in cancer-free individuals; odds ratio (OR) = 1.25; P = 0.016), with stronger association with cases who had DNA collected before diagnosis or treatment (OR = 1.45; P = 0.0005). Detectable mosaicism was also more common in individuals for whom DNA was collected at least 1 year before diagnosis with leukemia compared to cancer-free individuals (OR = 35.4; P = 3.8 × 10(-11)). These findings underscore the time-dependent nature of somatic events in the etiology of cancer and potentially other late-onset diseases
Existence and Uniqueness of Classical, Nonnegative, Smooth Solutions of a Class of Semi-Linear Spdes
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