Learning Network Assisted by Means of Symbolic Computation

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The finger flexors occlusion threshold in sport-climbers: an exploratory study on its indirect approximation

Blood flow partially determines specific climbing endurance (SCE) as it mediates oxygen bio-availability in the finger flexors. Blood flow is related to occlusion threshold (OT), which is defined as the contraction intensity at which intramuscular pressure exceeds perfusion blood pressure resulting in the cessation of local blood flow. The OT is represented as an inflection point on a force-time graph when isometric force is registered and applied through maximal and continuous tests. Endurance time (ET) to exhaustion is influenced by the relative isometric applied force and is different for each climber. The aim of this study was to explore whether an approximation of the finger flexors OT in sport climbers through records of ET to exhaustion at different isometric relative intensities was possible. We measured maximum finger hang ETs at 6 intensities ranging from 85% to 35% maximal force in 34 sport climbers of advanced and elite level. The values obtained were analysed by two different methods in an attempt to determine a change in the shape of the curve in the intensity-ET relationship graphs that approximated the OT for each climber. The results suggest that the finger flexors OT could be different among climbers, regardless of their strength and ability level. The presented methods do not accurately reflect the OT, but could indicate the intensity at which blood flow is restored in the active muscles. This is the first study to indirectly approximate the finger flexors OT in sport-climbers, a parameter that could be essential to assess SCE

A new performance threshold in sport climbing: A change in how climbing trainers work?

Objectives: Previous research has shown that the finger flexor's occlusion threshold (OT) could be different among sport climbers when expressed as a percentage of their maximum finger force (OT%), and that there is no association between the OT% and the climberś ability level. The aim of the present study was to evaluate the possible association between the relative finger force applied at the OT% (rff-OT%) and climbing ability level. Equipment and methods: WWe approximated the finger flexor's OT of 34 sport climbers by finger hang endurance test analyses at different intensities between 35% and 85% of their individual maximum finger force on a previously individually adapted edge depth, and we valued their rff-OT% as the relative force they could perform at that intensity. Results: We found a high correlation between the rff-OT% and climbing ability in elite climbers. These findings suggest that having an OT at the highest possible percentage is critical, in addition to having a high relative finger force, as this would enable climbers to express relative force at a wider range of intensities with favorable metabolic conditions

Ataxia and focal dystonia in Kallmann syndrome

A case of Kallmann syndrome (KS) associated with rare neurological manifestations is presented. Cerebellar ataxia probably caused by a small posterior fossa and a focal dystonia affecting the left lower limb expand the spectrum of neurological manifestations occurring in KS. Further studies are needed to better understand these manifestations

Multimodality Treatment for Early-Stage Hepatocellular Carcinoma: A Bridging Therapy for Liver Transplantation

Purpose: To evaluate the efficiency of a multimodality approach consisting of transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) as bridging therapy for patients with hepatocellular carcinoma (HCC) awaiting orthotopic liver transplantation (OLT) and to evaluate the histopathological response in explant specimens. Materials and Methods: Between April 2001 and November 2011, 36 patients with 50 HCC nodules (1.4-5.0 cm, median 2.8 cm) on the waiting list for liver transplantation were treated by TACE and RFA. The drop-out rate during the follow-up period was recorded. The local efficacy was evaluated by histopathological examination of the explanted livers. Results: During a median follow-up time of 29 (4.0-95.3) months the cumulative drop-out rate for the patients on the waiting list was 0, 2.8, 5.5, 11.0, 13.9 and 16.7% at 3, 6, 12, 24, 36 and 48 months, respectively. 16 patients (with 26 HCC lesions) out of 36(44.4%) were transplanted by the end of study with a median waiting list time of 13.7 (2.5-37.8) months. The histopathological examination of the explanted specimens revealed a complete necrosis in 20 of 26 HCCs (76.9%), whereas 6 (23.1%) nodules showed viable residual tumor tissue. All transplanted patients are alive at a median time of 29.9 months. Imaging correlation showed 100% specificity and 66.7% sensitivity for the depiction of residual or recurrent tumor. Conclusion: We conclude that TACE.combined with RFA could provide an effective treatment to decrease the drop-out rate from the OLT waiting list for HCC patients. Furthermore, this combination therapy results in high rates of complete tumor necrosis as evaluated in the histopathological analysis of the explanted livers. Further randomized trials are needed to demonstrate if there is a benefit in comparison with a single-treatment approach. copyright (C) 2012 S. Karger AG, Base

Effects of active video games on health-related physical fitness and motor competence in children and adolescents with overweight or obesity: Systematic review and meta-Analysis

Background: Childhood obesity is one of the most important public health problems. Active video games (AVGs) have been proposed as an attractive alternative to increase energy expenditure and are being investigated to determine their effectiveness against childhood obesity. Objective: The aim of this study is to summarize the existing research and draw conclusions about the effects of AVGs on health-related physical fitness and motor competence in children and adolescents with overweight and obesity. Methods: The search strategy was applied to PubMed, MEDLINE, Web of Science, and SPORTDiscus, including randomized and nonrandomized controlled trials investigating the effects of AVG programs on health-related physical fitness and motor competence in children and adolescents with overweight and obesity. To measure the risk of bias in randomized and nonrandomized controlled trials, 2 different quality assessment tools were used. In total, 15 articles met the inclusion criteria, and the variables of interest were BMI, body fat percentage, cardiorespiratory fitness (CRF), waist circumference, fat-free mass, muscular fitness, and motor competence. A meta-Analysis was performed. Results: Positive effects were found for BMI and body fat percentage, favoring the AVG group compared with a control group with no intervention (mean difference-0.209; 95% CI-0.388 to-0.031 vs mean difference-0.879; 95% CI-1.138 to-0.602). Positive effects seem to be observed for CRF. The effects of AVG interventions on muscular fitness, fat-free mass, waist circumference, and motor competence are unclear. Conclusions: AVG programs showed positive effects on BMI, body fat percentage, and CRF. AVG could be a good strategy to combat childhood obesity. © 2021. KJMIR Publications Inc.. All right reserved