Nitric oxide releasing-dendrimers: an overview

Platforms able to storage, release or scavenge NO in a controlled and specific manner is interesting for biological applications. Among the possible matrices for these purposes, dendrimers are excellent candidates for that. These molecules have been used as drug delivery systems and exhibit interesting properties, like the possibility to perform chemical modifications on dendrimers surface, the capacity of storage high concentrations of compounds of interest in the same molecule and the ability to improve the solubility and the biocompatibility of the compounds bonded to it. This review emphasizes the recent progress in the development and in the biological applications of different NO-releasing dendrimers and the nitric oxide release pathways in these compounds

Geodesy and contemporary strain in the Yucca Mountain region, Nevada

Geodetic surveys provide important information for estimating recent ground movement in support of seismotectonic investigations of the potential nuclear-waste storage site at Yucca Mountain, Nevada. Resurveys of established level lines document up to 22 millimeters of local subsidence related to the 1992 Little Skull Mountain earthquake, which is consistent with seismic data that show normal-slip rupture and with data from a regional trilateration network. Comparison of more recent surveys with a level line first established in 1907 suggests 3 to 13 centimeters of subsidence in the Crater Flat-Yucca Mountain structural depression that coincides with the Bare Mountain fault; small uplifts also were recorded near normal faults at Yucca Mountain. No significant deformation was recorded by a trilateration network over a 10-year period, except for coseismic deformation associated with the Little Skull Mountain earthquake, but meaningful results are limited by the short temporal period of that data set and the small rate of movement. Very long baseline interferometry that is capable of measuring direction and rates of deformation is likewise limited by a short history of observation, but rates of deformation between 8 and 13 millimeters per year across the basin and Range province are indicated by the available data

The Role of the State in Economic Development

This paper discusses the recent literature on the role of the state in economic development. It concludes that government incentives to enact sound policies are key to economic success. It also discusses the evidence on what happens after episodes of economic and political liberalizations, asking whether political liberalizations strengthen government incentives to enact sound economic policies. The answer is mixed. Most episodes of economic liberalizations are indeed preceded by political liberalizations. But the countries that have done better are those that have managed to open up the economy first, and only later have liberalized their political system. Copyright 2005 Blackwell Publishing Ltd..