31 research outputs found
Identification of new transitions and mass assignments of levels in Pr
The previously reported levels assigned to 151,152,153Pr have recently been
called into question regarding their mass assignment. The above questioned
level assignments are clarified by measuring g-transitions tagged with A and Z
in an in-beam experiment in addition to the measurements from 252Cf spontaneous
fission (SF) and establish new spectroscopic information from to
in the Pr isotopic chain. The isotopic chain 143-153Pr has been studied from
the spontaneous fission of 252Cf by using Gammasphere and also from the
measurement of the prompt g-rays in coincidence with isotopically-identified
fission fragments using VAMOS++ and EXOGAM at GANIL. The latter were produced
using 238U beams on a 9Be target at energies around the Coulomb barrier. The
g-g-g-g data from 252Cf (SF) and those from the GANIL in-beam A- and Z-gated
spectra were combined to unambiguously assign the various transitions and
levels in 151,152,153Pr and other isotopes. New transitions and bands in
145,147,148,149,150Pr were identified by using g-g-g and g-g-g-g coincidences
and A and Z gated g-g spectra. The transitions and levels previously assigned
to 151,153Pr have been confirmed by the (A,Z) gated spectra. The transitions
previously assigned to 152Pr are now assigned to 151Pr on the basis of the
(A,Z) gated spectra. Two new bands with 20 new transitions in 152Pr and one new
band with 7 new transitions in 153Pr are identified from the g-g-g-g
coincidence spectra and the (A,Z) gated spectrum. In addition, new g-rays are
also reported in 143-146Pr. New levels of 145,147-153Pr have been established,
reliable mass assignments of the levels in 151,152,153Pr have been reported and
new transitions have been identified in 143-146Pr showing the new avenues that
are opened by combining the two experimental approaches.Comment: Accepted in Phys. Rev.
Iterative graph cuts for image segmentation with a nonlinear statistical shape prior
Shape-based regularization has proven to be a useful method for delineating
objects within noisy images where one has prior knowledge of the shape of the
targeted object. When a collection of possible shapes is available, the
specification of a shape prior using kernel density estimation is a natural
technique. Unfortunately, energy functionals arising from kernel density
estimation are of a form that makes them impossible to directly minimize using
efficient optimization algorithms such as graph cuts. Our main contribution is
to show how one may recast the energy functional into a form that is
minimizable iteratively and efficiently using graph cuts.Comment: Revision submitted to JMIV (02/24/13
A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction
The developmental and physiological complexity of the auditory system is likely reflected in the underlying set of genes involved in auditory function. In humans, over 150 non-syndromic loci have been identified, and there are more than 400 human genetic syndromes with a hearing loss component. Over 100 non-syndromic hearing loss genes have been identified in mouse and human, but we remain ignorant of the full extent of the genetic landscape involved in auditory dysfunction. As part of the International Mouse Phenotyping Consortium, we undertook a hearing loss screen in a cohort of 3006 mouse knockout strains. In total, we identify 67 candidate hearing loss genes. We detect known hearing loss genes, but the vast majority, 52, of the candidate genes were novel. Our analysis reveals a large and unexplored genetic landscape involved with auditory function
Recruitment and Activation of RSK2 by HIV-1 Tat
The transcriptional activity of the integrated HIV provirus is dependent on the chromatin organization of the viral promoter and the transactivator Tat. Tat recruits the cellular pTEFb complex and interacts with several chromatin-modifying enzymes, including the histone acetyltransferases p300 and PCAF. Here, we examined the interaction of Tat with activation-dependent histone kinases, including the p90 ribosomal S6 kinase 2 (RSK2). Dominant-negative RSK2 and treatment with a small-molecule inhibitor of RSK2 kinase activity inhibited the transcriptional activity of Tat, indicating that RSK2 is important for Tat function. Reconstitution of RSK2 in cells from subjects with a genetic defect in RSK2 expression (Coffin-Lowry syndrome) enhanced Tat transactivation. Tat interacted with RSK2 and activated RSK2 kinase activity in cells. Both properties were lost in a mutant Tat protein (F38A) that is deficient in HIV transactivation. Our data identify a novel reciprocal regulation of Tat and RSK2 function, which might serve to induce early changes in the chromatin organization of the HIV LTR
Genetics of Childhood Disorders: LII. Learning and Memory, Part 5: Human Cognitive Disorders and the ras/ERK/CREB Pathway
Genetics of Childhood Disorders: LI. Learning and Memory, Part 4: Human Cognitive Disorders and the ras/ERK/CREB Pathway
The thioredoxin-mediated recycling of Arabidopsis thaliana GRXS16 relies on a conserved C-terminal cysteine
Deformed band structures in neutron-rich Pm isotopes
International audienceHigh spin band structures of neutron-rich Pm152–158 isotopes have been obtained from the measurement of prompt γ rays of isotopically identified fragments produced in fission of U238+Be9 and detected using the VAMOS++ magnetic spectrometer and EXOGAM segmented Clover array at GANIL and also from the high statistics γ-γ-γ and γ-γ-γ-γ data from the spontaneous fission of Cf252 using Gammasphere. The excited states in Pm157 and those above the isomers in even-A Pm isotopes Pm152,154,156,158 have been identified for the first time. The spectroscopic information on the rotational band structures in odd-A Pm isotopes has been extended considerably to higher spins and the possibility of the presence of reflection asymmetric shapes is explored. The configuration assignments are based on the results of cranked relativistic Hartree-Bogoliubov calculations. From the systematics of bands in odd-A Pm isotopes and weak population of opposite parity bands, octupole deformed shapes in neutron-rich Pm isotopes beyond N=90 seem unlikely to be present