9,731 research outputs found
Oxidized (non)-regenerated cellulose affects fundamental cellular processes of wound healing.
In this study we investigated how hemostats such as oxidized regenerated cellulose (ORC, TABOTAMP) and oxidized non-regenerated cellulose (ONRC, RESORBA CELL) influence local cellular behavior and contraction of the extracellular matrix (ECM). Human stromal fibroblasts were inoculated in vitro with ORC and ONRC. Cell proliferation was assayed over time, and migration was evaluated by Live Cell imaging microscopy. Fibroblasts grown in collagen-gels were treated with ORC or ONRC, and ECM contraction was measured utilizing a contraction assay. An absolute pH decline was observed with both ORC and ONRC after 1 hour. Mean daily cell proliferation, migration and matrix contraction were more strongly inhibited by ONRC when compared with ORC (p < 0.05). When control media was pH-lowered to match the lower pH values typically seen with ORC and ONRC, significant differences in cell proliferation and migration were still observed between ONRC and ORC (p < 0.05). However, in these pH conditions, inhibition of matrix contraction was only significant for ONRC (p < 0.05). We find that ORC and ONRC inhibit fibroblast proliferation, migration and matrix contraction, and stronger inhibition of these essential cellular processes of wound healing were observed for ONRC when compared with ORC. These results will require further validation in future in vivo experiments to clarify the clinical implications for hemostat use in post-surgical wound healing
Non-Abelian Proca model based on the improved BFT formalism
We present the newly improved Batalin-Fradkin-Tyutin (BFT) Hamiltonian
formalism and the generalization to the Lagrangian formulation, which provide
the much more simple and transparent insight to the usual BFT method, with
application to the non-Abelian Proca model which has been an difficult problem
in the usual BFT method. The infinite terms of the effectively first class
constraints can be made to be the regular power series forms by ingenious
choice of and -matrices. In this new
method, the first class Hamiltonian, which also needs infinite correction terms
is obtained simply by replacing the original variables in the original
Hamiltonian with the BFT physical variables. Remarkably all the infinite
correction terms can be expressed in the compact exponential form. We also show
that in our model the Poisson brackets of the BFT physical variables in the
extended phase space are the same structure as the Dirac brackets of the
original phase space variables. With the help of both our newly developed
Lagrangian formulation and Hamilton's equations of motion, we obtain the
desired classical Lagrangian corresponding to the first class Hamiltonian which
can be reduced to the generalized St\"uckelberg Lagrangian which is non-trivial
conjecture in our infinitely many terms involved in Hamiltonian and Lagrangian.Comment: Notable improvements in Sec. I
BRST Quantization of the Proca Model based on the BFT and the BFV Formalism
The BRST quantization of the Abelian Proca model is performed using the
Batalin-Fradkin-Tyutin and the Batalin-Fradkin-Vilkovisky formalism. First, the
BFT Hamiltonian method is applied in order to systematically convert a second
class constraint system of the model into an effectively first class one by
introducing new fields. In finding the involutive Hamiltonian we adopt a new
approach which is more simpler than the usual one. We also show that in our
model the Dirac brackets of the phase space variables in the original second
class constraint system are exactly the same as the Poisson brackets of the
corresponding modified fields in the extended phase space due to the linear
character of the constraints comparing the Dirac or Faddeev-Jackiw formalisms.
Then, according to the BFV formalism we obtain that the desired resulting
Lagrangian preserving BRST symmetry in the standard local gauge fixing
procedure naturally includes the St\"uckelberg scalar related to the explicit
gauge symmetry breaking effect due to the presence of the mass term. We also
analyze the nonstandard nonlocal gauge fixing procedure.Comment: 29 pages, plain Latex, To be published in Int. J. Mod. Phys.
Suppression of backward scattering of Dirac fermions in iron pnictides Ba(FeRuAs)
We report electronic transport of Dirac cones when Fe is replaced by Ru,
which has an isoelectronic electron configuration to Fe, using single crystals
of Ba(FeRuAs). The electronic transport of parabolic bands is
shown to be suppressed by scattering due to the crystal lattice distortion and
the impurity effect of Ru, while that of the Dirac cone is not significantly
reduced due to the intrinsic character of Dirac cones. It is clearly shown from
magnetoresistance and Hall coefficient measurements that the inverse of average
mobility, proportional to cyclotron effective mass, develops as the square root
of the carrier number (n) of the Dirac cones. This is the unique character of
the Dirac cone linear dispersion relationship. Scattering of Ru on the Dirac
cones is discussed in terms of the estimated mean free path using experimental
parameters.Comment: 6 pages, 3 figures, To be published in Phys. Rev.
Structural study on hole-doped superconductors Pr1-xSrxFeAsO
The structural details in Pr1-xSrxFeAsO (1111) superconducting system are
analyzed using data obtained from synchrotron X-ray diffraction and the
structural parameters are carefully studied as the system is moving from
non-superconducting to hole-doped superconducting with the Sr concentration.
Superconductivity emerges when the Sr doping amount reaches 0.221. The linear
increase of the lattice constants proves that Sr is successfully introduced
into the system and its concentration can accurately be determined by the
electron density analyses. The evolution of structural parameters with Sr
concentration in Pr1-xSrxFeAsO and their comparison to other similar structural
parameters of the related Fe-based superconductors suggest that the interlayer
space between the conducting As-Fe-As layer and the insulating Pr-O-Pr layer is
important for improving Tc in the hole-doped (1111) superconductors, which
seems to be different from electron-doped systems.Comment: 17 pages, 7 figures, 1 tabl
Disrupted Capacitated Vehicle Routing Problem with Order Release Delay
With the popularity of the just-in-time system, more and more companies are operating with little or no inventories, which make them highly vulnerable to delays on supply. This paper discusses a situation when the supply of the commodity does not arrive at the depot on time, so that not enough of the commodity is available to be loaded on all vehicles at the start of the delivery period. New routing plans need to be developed in such a case to reduce the impact the delay of supply may have on the distribution company. The resulting vehicle routing problem is different from other types of vehicle routing problems as it involves waiting and multiple trips. Two approaches have been developed to solve the order release delay problem, both of which involve a Tabu Search algorithm. Computational results show the proposed approaches can largely reduce the disruption costs that are caused by the delayed supply and they are especially effective when the length of delay is long
Pressure Effect on the superconducting properties of LaO_{1-x}F_{x}FeAs(x=0.11) superconductor
Diamagnetic susceptibility measurements under high hydrostatic pressure (up
to 1.03 GPa) were carried out on the newly discovered Fe-based superconductor
LaO_{1-x}F_{x}FeAs(x=0.11). The transition temperature T_c, defined as the
point at the maximum slope of superconducting transition, was enhanced almost
linearly by hydrostatic pressure, yielding a dT_c/dP of about 1.2 K/GPa.
Differential diamagnetic susceptibility curves indicate that the underlying
superconducting state is complicated. It is suggested that pressure plays an
important role on pushing low T_c superconducting phase toward the main
(optimal) superconducting phase.Comment: 7 pages, 4 figure
Association of consciousness impairment and mortality in people with COVID-19
BACKGROUND: To investigate the association between impairment of consciousness and risk of death in people with COVID-19. METHODS: In this multicentre retrospective study, we enrolled people with confirmed COVID-19 from 44 hospitals in Wuhan and Sichuan, China, between 18 January and 30 March 2020. We extracted demographics, clinical, laboratory data and consciousness level (as measured by the Glasgow Coma Scale (GCS) score) from medical records. We used Cox proportional hazards regression, structural equation modelling and survival time analysis to compare people with different progressions of impaired consciousness. RESULTS: We enrolled 1,143 people (average age 51.3 ± standard deviation 17.1-year-old; 50.3% males), of whom 76 died. Increased mortality risk was identified in people with GCS score between 9 and 14 (hazard ratio (HR) 46.76, p 2 days, p = .028) had shorter survival times. CONCLUSION: Altered consciousness and its progression had a direct link with death in COVID-19. Interactions with age, oxygen saturation level and pH suggest possible pathophysiology. Further work to confirm these findings explore prevention strategies and interventions to decrease mortality is warranted
SHCal13 Southern Hemisphere calibration, 0–50,000 years cal BP
The Southern Hemisphere SHCal04 radiocarbon calibration curve has been updated with the addition of new data sets extending measurements to 2145 cal BP and including the ANSTO Younger Dryas Huon pine data set. Outside the range of measured data, the curve is based upon the Northern Hemisphere data sets as presented in IntCal13, with an interhemispheric offset averaging 43 ± 23 yr modeled by an autoregressive process to represent the short-term correlations in the offset
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