1,705 research outputs found
Possible mechanism for changes in glycogen metabolism in unloaded soleus muscle
Carbohydrate metabolism has been shown to be affected in a number of ways by different models of hypokinesia. In vivo glycogen levels in the soleus muscle are known to be increased by short-term denervation and harness suspension. In addition, exposure to 7 days of hypogravity also caused a dramatic increase in glycogen concentration in this muscle. The biochemical alterations caused by unloading that may bring about these increases in glycogen storage in the soleus were sought
A high pass, mechanical velocity filter for fast neutral molecular beams
Design and transmission characteristics of high pass, mechanical velocity filter for fast neutral molecular or atomic beam
Identification and verification of frequency-domain models for XV-15 tilt-rotor aircraft dynamics
Frequency-domain methods are used to extract the open-loop dynamics of the XV-15 tilt-rotor aircraft from flight test data for the cruise condition (V = 170 knots). The frequency responses are numerically fitted with transfer-function forms to identify equivalent model characteristics. The associated handling quality parameters meet or exceed Level 2, Category A, requirements for fixed-wing military aircraft. Step response matching is used to verify the time-domain fidelity of the transfer-function models for the cruise and hover flight conditions. The transient responses of the model and aircraft are in close agreement in all cases, except for the normal acceleration response to elevator deflection in cruise. This discrepancy is probably due to the unmodeled rotor rpm dynamics. The utility of the frequency-domain approach for dynamics identification and analysis is clearly demonstrated
Responses of skeletal muscle to unloading, a review
Suspension models were used to study muscle response to reduced activity. During 6 days of tail casting, the soleus (SOL) atrophies while the extensor digitorum longus grows relatively normally. After discounting those changes in both muscles due primarily to increased secretion of adrenal hormones, the following conclusions regarding the specific responses of the SOL could be drawn: (1) Atrophy is probably due primarily to increased protein degradation; (2) Decreased synthesis of glutamine may result from reduced availability of ammonia due to diminished use of ATP; (3) Greater muscle glycogen seems to reflect an increased response to insulin of glucose uptake which leads to greater glucose metabolism; and (4) Faster catabolism of branched-chain amino acids can be attributed to enhanced flux through ketoacid dehydrogenase. Studies by others using tail casted suspended rats showed in the SOL: (1) a gradual switch from type 1 to type 2 fibers; (2) increased acid protease activity; and (3) altered muscle function and contractile duration. Using harness suspended rats, others showed in the SOL: (1) significant atrophy; (2) increased numbers of glucocorticoid receptors; and (3) no change in muscle fatigability
Response of rat hindlimb muscles to 12 hours recovery from tail-cast suspension
Previous work has shown a number of biochemical changes which accompany atrophy or reduced muscle growth in hindlimb of tail-casted, suspended rats. These results clearly show that altered muscle growth was due to changes in protein turnover. Accordingly, the rise in soleus tyrosine following unloading reflects the more negative protein balance. Other major changes we found included slower synthesis of glutamine as indicated by lower ratios of glutamine/glutamate and reduced levels of aspartate which coincide with slower aspartate and ammonia metabolism in vitro. In conjunction with the study of SL-3 rats, which were subjected to 12 h of post-flight gravity, a study of the effects of 12 h eight bearing on metabolism of 6-day unloaded hindlimb muscles was carried out
Muscle protein and glycogen responses to recovery from hypogravity and unloading by tail-cast suspension
Previous studies in this laboratory using the tail-bast hindlimb suspension model have shown that there are specific changes in protein and carbohydrate metabolism in the soleus muscle due to unloading. For example, 6 days of unloading caused a 27% decrease in mass and a 60% increase in glycogen content in the soleus muscle, while the extensor digitorum longus muscle was unaffected. Also, fresh tissue tyrosine and its in vitro release from the muscle are increased in the unloaded soleus, indicating that this condition causes a more negative protein balance. With these results in mind, studies to investigate the effect of hypogravity on protein and carbohydrate metabolism in a number of rat hindlimb muscles were carried out
Interfering trajectories in experimental quantum-enhanced stochastic simulation
Simulations of stochastic processes play an important role in the
quantitative sciences, enabling the characterisation of complex systems. Recent
work has established a quantum advantage in stochastic simulation, leading to
quantum devices that execute a simulation using less memory than possible by
classical means. To realise this advantage it is essential that the memory
register remains coherent, and coherently interacts with the processor,
allowing the simulator to operate over many time steps. Here we report a
multi-time-step experimental simulation of a stochastic process using less
memory than the classical limit. A key feature of the photonic quantum
information processor is that it creates a quantum superposition of all
possible future trajectories that the system can evolve into. This
superposition allows us to introduce, and demonstrate, the idea of comparing
statistical futures of two classical processes via quantum interference. We
demonstrate interference of two 16-dimensional quantum states, representing
statistical futures of our process, with a visibility of 0.96 0.02.Comment: 9 pages, 5 figure
Strong unitary and overlap uncertainty relations: theory and experiment
We derive and experimentally investigate a strong uncertainty relation valid
for any unitary operators, which implies the standard uncertainty relation
as a special case, and which can be written in terms of geometric phases. It is
saturated by every pure state of any -dimensional quantum system, generates
a tight overlap uncertainty relation for the transition probabilities of any
pure states, and gives an upper bound for the out-of-time-order
correlation function. We test these uncertainty relations experimentally for
photonic polarisation qubits, including the minimum uncertainty states of the
overlap uncertainty relation, via interferometric measurements of generalised
geometric phases.Comment: 5 pages of main text, 5 pages of Supplemental Material.
Clarifications added in this updated versio
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