LORAN-C, an overview

LORAN-C a highly accurate radio navigation positioning system which operates at an assigned frequency of 10 kHz, and provides phase-coded pulses to develop hyperbolic time-difference lines-of-position (LOP's) was evaluated. LORAN-C provides precise time and time interval to within plus or minus 5 microseconds of UTC. The steps taken to plan, install, operate, and maintain the LORAN-C system up to the year 2000 are discussed. Topics included in the discussion were: theory of operation, timing, chain lanning, group repetition interval, coding delay versus emission delay, chain calibration, chart verification, system accuracy, signal reliability, and future developments

Mean and mean square measurements of nonstationary random processes

Mean and mean square measurements of nonstationary random processes - orthogonal function analysis and computer simulatio

A summary of methods for analyzing nonstation- ary data

Estimation of nonstationary mean values, spectral density, and correlation functions - summary of methods for analyzing nonstationary dat

Use of the ThinPrep® Imaging System does not alter the frequency of interpreting Papanicolaou tests as atypical squamous cells of undetermined significance

<p>Abstract</p> <p>Background</p> <p>Automated screening of Papanicolaou tests (Pap tests) improves the productivity of cytopathology laboratories. The ThinPrep^®Imaging System (TIS) has been widely adopted primarily for this reason for use on ThinPrep^®Pap tests (TPPT). However, TIS may also influence the interpretation of Pap tests, leading to changes in the frequency of various interpretive categories. The effect of the TIS on rates of TPPT interpretation as atypical squamous cells of undetermined significance (ASC-US) is of concern because any shift in the frequency of ASC-US will alter the sensitivity and specificity of the Pap test. We have sought to determine whether automated screening of TPPT has altered ASC-US rates in our institution when compared with manual screening (MS) of TPPT.</p> <p>Methods</p> <p>A computerized search for all ASC-US with reflex Human Papillomavirus (HPV) testing over a one-year-period (7/1/06 to 6/30/07) was conducted. Cases included both TPPT screened utilizing TIS and screened manually. HPV test results for both groups were recorded. Pertinent follow-up cervical cytology and histology results were retrieved for the period extending to 11/30/07. Automated screening was in clinical use for 10 months prior to the start of the study.</p> <p>Results</p> <p>Automated screening was performed on 23,103 TPPT, of which 977 (4.23%) were interpreted as ASC-US. Over the same period, MS was performed on 45,789 TPPT, of which 1924 (4.20%) were interpreted as ASC-US. Reflex HPV testing was positive for high risk (HR) types in 47.4% of the TIS cases and 50.2% of MS cases. Follow-up cervical dysplasia found by colposcopy was also distributed proportionally between the two groups. Cervical intraepithelial neoplasia (CIN) was found on follow-up biopsy of 20.1% of the TIS cases (5.2% CIN 2/3) and 21.2% of MS cases (5.1% CIN 2/3). None of these differences were statistically significant.</p> <p>Conclusion</p> <p>Use of the ThinPrep^®Imaging System did not appreciably change ASC-US rates or follow-up reflex HPV test results in our laboratory. This demonstrates that the benefits of automated screening may be obtained without increasing the rate of referral to colposcopy for ASC-US follow-up.</p