Chronobiology of high blood pressure

BIOCOS, the project aimed at studying BIOlogical systems in their COSmos, has obtained a great deal of expertise in the fields of blood pressure (BP) and heart rate (HR) monitoring and of marker rhythmometry for the purposes of screening, diagnosis, treatment, and prognosis. Prolonging the monitoring reduces the uncertainty in the estimation of circadian parameters; the current recommendation of BIOCOS requires monitoring for at least 7 days. The BIOCOS approach consists of a parametric and a non-parametric analysis of the data, in which the results from the individual subject are being compared with gender- and age-specified reference values in health. Chronobiological designs can offer important new information regarding the optimization of treatment by timing its administration as a function of circadian and other rhythms. New technological developments are needed to close the loop between the monitoring of blood pressure and the administration of antihypertensive drugs

Chronomics: the broad scope of monitoring chronomes : a review

The aim of the present paper is to summarized the data on biological rhythms in living organisms including man and summarise data on circadian, circaseptan and other rhythms in geophysical variables. The synchronisation of both geophysical and biological activities and their oscillations are discussed

Can society afford not to follow a chronobiological approach to blood pressure screening, diagnosis and treatment?

Stadtarchiv Solingen, Bergische Arbeiterstimme 29. Juli 1916 Treibriemendiebstähle in Ohligser Firmen.    Ohligs. Treibriemendiebe! Die Diebstähle von Treibriemen nehmen in der hiesigen Gegend überhand. Fabrik- betriebe werden durch ihre Entwendung ganz oder teilweise stillgelegt, so daß auch den Arbeitern ein erheblicher Schaden dadurch erwächst. Der hiesigen Bahnhofswache ist es heute nacht gelungen, einen Maschinenschlosser aus Köln festzunehmen, der einen Karton mit Treibriemenstück..

Aspirin and the blood pressure and heart rate of healthy women

Aspirin and the blood pressure and heart rate of healthy wome

Near 10 years and longer periods modulate circadians: intersecting anti aging and chronoastrobiological research

Biological cycles with relatively long and some unusual periods in the range of the half-week, the half-year, years, or decades are being discovered. Their prior neglect constituted a confounder in aging and much other research, which then \u201cflew blind\u201d concerning the uncertainties associated with these cycles when they are not assessed. The resolution of more about 10-year and other cycles, some reported herein, replaces the admission of complete unpredictability, implied by using the label \u201csecularity.\u201d Heretofore unaccounted-for variability becomes predictable insofar as it proves to be rhythmic and is mapped systematically to serve as a battery of useful reference values. About 10-year cycles in urinary 17-ketosteroid excretion and in heart rate and its variability, among others, are aligned with cycles of similar length in mortality from myocardial infarction. Associations accumulate between cycles of natural physical time structures, chronomes such as the 10.5-year (circadecennian) Schwabe and the 21-year (circavigintunennian) Hale cycles of solar activity, and chronomes in biota. There are about 50-year (circasemicentennian) cycles in mortality from stroke in Minnesota and in the Czech Republic and also in human morphology at birth, the latter result reducing the likelihood that these cycles are purely human made. Associations among large populations warrant long-term systematic coordinated sampling of natural physical and biological variables of interest for the design of countermeasures against already documented elevated risks of stroke, myocardial infarction, and other catastrophic diseases, notably in elderly adults. New findings will be introduced against the background of the documented value of mapping rhythms in medicine and gerontology. In both these fields, rhythms promise the seeming paradox of better care for less