Pregnancy and heart disease: risk and predictors of obstetric complications

Background: Although the disease is limited to only 0.5 to 1.0 percent of pregnant women, it remains an important cause of maternal morbidity and even mortality and has a significant effect on fetal outcome. Pregnancy and the peripartum period are associated with important cardiocirculatory changes that can lead to marked clinical deterioration in the woman with heart disease. Objectives of present study were to comprehend the impact of heart disease during pregnancy, to study the maternal and neonatal outcomes of pregnancies in women with heart disease, to identify predictors of pregnancy related complications in women with heart disease and to refine the risk stratification and to assess the individual risk of each pregnant woman with heart disease.Methods: It is a perspective study carried out at College Department of Obstetrics and Gynaecology, Govt. Medical, Kottayam from January 2012 to March 2014.Results: The outcomes of the pregnancies in 100 women who presented with heart disease and received their obstetrical care were evaluated. A maternal cardiac event, neonatal event, or both occurred in 37 completed pregnancies. A cardiac event complicated 8 completed pregnancies. It includes 2 maternal deaths, one on 9th postnatal day in women with hypertrophic obstructive cardiomyopathy and another in women with rheumatoid mitral stenosis who died of congestive cardiac failure. Most cardiac events (75%) occurred in the antepartum period and were either heart failure or cardiac arrhythmia.Conclusions: Strict prenatal care and early risk stratification during gestation are fundamental measures to improve the prognosis of pregnancy in women with heart disease

Ramping Up Rural Workforce Development: An Extension-Centered Model

Workforce development is a growing need in rural communities. This article recognizes Cooperative Extension as a critical labor market intermediary in fostering local workforce solutions. It proposes a community-based approach with Extension at the center of a process for identifying key stakeholders, facilitating collaboration, and supporting data-driven decisions. Through participatory methods and economic analysis of local industries, our team engaged over 120 stakeholders from two rural regions in the Great Plains. Our findings show that Extension plays an important role in promoting cross-sectoral collaboration to address complex workforce issues, enhance community capacity, and mobilize local action

Effect of hydration therapy on oligohydramnios

Background: Oligamnios is defined as an AFI 34 weeks with AFI <5 cms were randomised into an Intervention group who receive 1 litre of ringer lactate i.v given daily for 5 days and nonintervention group who were kept under observation by serial ultrasound and antepartum fetal surveillance. All were followed-up till delivery to obtain maternal and perinatal outcomes.Results: Among the 68 who were given intervention, 61 responded and 7 were non responders. With hydration therapy, mean increase in AFI was 4 cm and minimum duration needed for improvement was one week. Hydration therapy showed significant improvement in the maternal and fetal outcomes. Intravenous route of maternal hydration has the advantage that a fixed amount of fluid can be infused at a relatively constant rate with ensured compliance.Conclusions: From the study, it was concluded that Hydration therapy is an excellent method to improve AFI in Oligohydramnios and maternal and perinatal outcome

Senior citizens and over the counter drugs: challenges in rural India

Background: The geriatric population is on a rise in India, which is accompanied by an increase in their health care needs. As they are prone to have multiple diseases simultaneously the tendency for over the counter (OTC) or non-prescription drugs is much higher among the elderly population. A thorough knowledge about the medication practices among elderly is indispensable since the chances for adverse drugs events; drug interactions etc. are higher among them. The primary objective of the present study was to measure the prevalence of over the counter drug usage among those aged 60 years or above residing in a rural block of North Tamilnadu, India.Methods: A community based cross sectional study was conducted among those aged 60 years or above using an interviewer administered questionnaire and data was collected from 100 consenting participants who were selected using multi stage sampling.Results: The prevalence of the usage of over the counter drugs among the elderly population was found to be 51% (95% CI 41.1-60.9). It was shown that the usage of OTC drugs was associated with higher socio economic status (p value 0.015) and literacy (p value 0.003).Conclusions: Further studies need to done to identify whether such high prevalence of OTC drug usage among elderly is a reflection of drug practices among general population and if proven otherwise should explore the various reasons for the same so that necessary measures can be implemented to alleviate the situation.

Spider Search Algorithms for MIMO System and Assessment Using Simatic PCS7

This paper shows two optimization methods that are built on a spider optimization algorithm to enhance the proportional integral and derivative (PID) gain values for multiple-input-multiple-output (MIMO) arrangement which is automated with SIMATIC PCS7 Distributed Control System (SDCS). The leading methodologies are the Spider Search Algorithm (SSA) and Social Spider Optimization (SSO) which is meant primarily for optimizing PID gain values. The SSA is based on foraging strategy of colonial spiders and SSO works on the combined plan of the male and female spiders that removes the episodes of local optimization and exploration elusion. Thus, SSA and SSO are contrived for the ideal fine-tuning of PID conditions in the benchmark MIMO procedure. The system performance is understood by minimizing the integral absolute error (IAE) and the integral square error (ISE) as its objective functions. The time-domain features are examined for the aforesaid methods and thereafter compared with the previous genetic algorithm (GA). The settling time is 60s for the proposed method which is lesser than the other techniques. For illustrating the implemented controller\u27s strength, interference is manually presented in the real-time system. Findings indicate that the SSO surpasses output measures and performance indices beyond the presupposed SSA and GA intervals

Histone deacetylases 1 and 2 silence cryptic transcription to promote mitochondrial function during cardiogenesis

Cryptic transcription occurs widely across the eukaryotic genome; however, its regulation during vertebrate development is not understood. Here, we show that two class I histone deacetylases, Hdac1 and Hdac2, silence cryptic transcription to promote mitochondrial function in developing murine hearts. Mice lacking Hdac1 and Hdac2 in heart exhibit defective developmental switch from anaerobic to mitochondrial oxidative phosphorylation (OXPHOS), severe defects in mitochondrial mass, mitochondrial function, and complete embryonic lethality. Hdac1/Hdac2 promotes the transition to OXPHOS by enforcing transcriptional fidelity of metabolic gene programs. Mechanistically, Hdac1/Hdac2 deacetylates histone residues including H3K23, H3K14, and H4K16 to suppress cryptic transcriptional initiation within the coding regions of actively transcribed metabolic genes. Thus, Hdac1/2-mediated epigenetic silencing of cryptic transcription is essential for mitochondrial function during early vertebrate development

An Optimal Lysis Time Maximizes Bacteriophage Fitness in Quasi-Continuous Culture

Optimality models have a checkered history in evolutionary biology. While optimality models have been successful in providing valuable insight into the evolution of a wide variety of biological traits, a common objection is that optimality models are overly simplistic and ignore organismal genetics. We revisit evolutionary optimization in the context of a major bacteriophage life history trait, lysis time. Lysis time refers to the period spanning phage infection of a host cell and its lysis, whereupon phage progenies are released. Lysis time, therefore, directly determines phage fecundity assuming progeny assembly does not exhaust host resources prior to lysis. Noting that previous tests of lysis time optimality rely on batch culture, we implemented a quasi-continuous culture system to observe productivity of a panel of isogenic phage λ genotypes differing in lysis time. We report that under our experimental conditions, λ phage productivity is maximized around optimal lysis times ranging from 60 to 100 min, and λ wildtype strain falls within this range. It would appear that natural selection on phage λ lysis time uncovered a set of genetic solutions that optimized progeny production in its ecological milieu relative to alternative genotypes. We discuss this finding in light of recent results that lysis time variation is also minimized in the strains with lysis times closer to the λ wild-type strain

Extensibility of External Magnetic Potential at High Latitudes - Antarctica

We investigated the external magnetic potential due to solar forcing, with nine years of data during 2001-2009, coveringthe deep solar minimum (2006-2009), at two stations: one is in the polar cap -Vostok (78º27'S, 106º52’E; mag. lat 83oS) andanother is in the subauroral region - Maitri (70º45'S, 11º43'E: mag. lat 67oS) in Antarctica. The significance of the work isassociated with space weather prediction and its impact on planet Earth. We used Advance Composition Explorer (ACE)satellite data for the aforesaid period for a thorough understanding of influences due to solar wind origin and to compare theparameter observed in these regions. We used the spherical cap harmonic analysis (SCHA) function as a tool. The inferenceindicates that at Vostok the magnitude is enhanced throughout and depicts a broad ambient external magnetic potential. Itseems to be essentially the intensification of the region 1 currents whereas at Maitri intense electric fields are producedduring geomagnetic perturbations which drive a system of disturbed time Region 2 currents over the quiet time currents.During this scenario in Maitri there are noticeable peaks or enhancements in the magnetic potential that can be observedmainly during geomagnetic disturbances. Hence the regression relation developed for external magnetic potentialcalculation, in terms of solar wind parameters agrees well with polar cap region and the area is relatively less exploredearlier, the present investigation can be expected to add knowledge about that regime

Multiple Bandwidth FIR Filter Design with Adaptive Algorithms for Hearing Aid Systems

Digital Filter design plays a vital role in signal processing and communication applications. This paper proposes a hearing loss system model with Variable Bandwidth FIR Filter (VBF) and adaptive algorithms for the application to listening. The tunable band filter is designed to provide an appropriate sound level. This filter has several sub-filters each of which is designed with set of selected bandwidths. The sub-bands obtained are adjusted with proper magnitude by trial and error method. Algorithms such as Least Mean Square (LMS), Normalized Least Mean Square (NLMS) and Recursive Least Squares (RLS) are incorporated to improve the quality of the signal. The filter thus designed is examined by taking a number of audio signals. The tests on various hearing loss cases with different type of input signal suggest that this method is capable of reproducing a signal which sounds exactly the same as the original signal. The multiple bandwidth filters is analyzed with mild, moderate, profound and severe hearing loss patterns and the results are reported. The matching error is calculated between ideal response and actual response. The result show that the designed filter provides acceptable minimum matching error and it lies in the range 0 to 2.5dB.This filter design is implemented in TMS320C6711 processor and is tested for sinusoidal input signal