Differential inflammatory microRNA and cytokine expression in pulmonary sarcoidosis

Sarcoidosis is a granulomatous disease of unknown etiology. The disease has an important inflammatory and immune component; however, its immunopathogenesis is not completely understood. Recently, the role of microRNAs (miRNAs), the small non-coding RNAs, has attracted attention as both being involved in pathogenesis and serving as disease markers. Accordingly, changes in the expression of some miRNAs have been also associated with different autoimmune pathologies. However, not much is known about the role of miRNAs in sarcoidosis. Therefore, the aim of this study was to compare the level of expression of selected miRNAs in healthy individuals and patients with sarcoidosis. We detected significantly increased level of miR-34a in peripheral blood mononuclear cells isolated from sarcoidosis patients. Moreover, significantly up-regulated levels of interferon (IFN)-γ, IFN-γ inducible protein (IP-10) and vascular endothelial growth factor were detected in sera of patients when compared to healthy subjects. Our results add to a known inflammatory component in sarcoidosis. Changes in the levels of miR-34a may suggest its involvement in the pathology of this disease

Pinski Zoo

A truly original contemporary jazz outfit from the UK. Almost impossible to categorize they swing from virtuosic jazz to gritty funk with freedom and movement, veering into leftfleld territory and returning with snappy anthem-like tunes. Unpredictable and exciting, they carved a unique style in the UK and won praise from critics at home and abroad. Their eclectic fusion of style foreshadowed the move towards mixing influences in much of today's modern music. With 8 albums and extensive touring in Europe, Poland and New York in the late 80's and 90's and a "Best British Band" at the British International Jazz Awards in '91 they are back after several years of individual projects