Contributions of temporal encodings of voicing, voicelessness, fundamental frequency, and amplitude variation to audiovisual and auditory speech perception

Auditory and audio-visual speech perception was investigated using auditory signals of invariant spectral envelope that temporally encoded the presence of voiced and voiceless excitation, variations in amplitude envelope and F-0. In experiment 1, the contribution of the timing of voicing was compared in consonant identification to the additional effects of variations in F-0 and the amplitude of voiced speech. In audio-visual conditions only, amplitude variation slightly increased accuracy globally and for manner features. F-0 variation slightly increased overall accuracy and manner perception in auditory and audio-visual conditions. Experiment 2 examined consonant information derived from the presence and amplitude variation of voiceless speech in addition to that from voicing, F-0, and voiced speech amplitude. Binary indication of voiceless excitation improved accuracy overall and for voicing and manner. The amplitude variation of voiceless speech produced only a small increment in place of articulation scores. A final experiment examined audio-visual sentence perception using encodings of voiceless excitation and amplitude variation added to a signal representing voicing and F-0. There was a contribution of amplitude variation to sentence perception, but not of voiceless excitation. The timing of voiced and voiceless excitation appears to be the major temporal cues to consonant identity. (C) 1999 Acoustical Society of America. [S0001-4966(99)01410-1]

Narrative, identity, and recovery from serious mental illness: A life history of a runner

In recent years, researchers have investigated the psychological effects of exercise for people with mental health problems, often by focusing on how exercise may alleviate symptoms of mental illness. In this article I take a different tack to explore the ways in which exercise contributed a sense of meaning, purpose, and identity to the life of one individual named Ben, a runner diagnosed with schizophrenia. Drawing on life history data, I conducted an analysis of narrative to explore the narrative types that underlie Ben's stories of mental illness and exercise. For Ben, serious mental illness profoundly disrupted a pre-existing athletic identity removing agency, continuity, and coherence from his life story. By returning to exercise several years later, Ben reclaimed his athletic identity and reinstated some degree of narrative agency, continuity, and coherence. While the relationships between narrative, identity, and mental health are undoubtedly complex, Ben's story suggests that exercise can contribute to recovery by being a personally meaningful activity which reinforces identity and sense of self

Adventures in Holographic Dimer Models

We abstract the essential features of holographic dimer models, and develop several new applications of these models. First, semi-holographically coupling free band fermions to holographic dimers, we uncover novel phase transitions between conventional Fermi liquids and non-Fermi liquids, accompanied by a change in the structure of the Fermi surface. Second, we make dimer vibrations propagate through the whole crystal by way of double trace deformations, obtaining nontrivial band structure. In a simple toy model, the topology of the band structure experiences an interesting reorganization as we vary the strength of the double trace deformations. Finally, we develop tools that would allow one to build, in a bottom-up fashion, a holographic avatar of the Hubbard model.Comment: 22 pages, 8 figures; v2: brief description of case of pure D5 lattice added in sec.3; v3: minor typo fixed; v4: minor change

Virtual-crystal approximation that works: Locating a composition phase boundary in Pb(Zr_{1-x}Ti_3)O_3

We present a new method for modeling disordered solid solutions, based on the virtual crystal approximation (VCA). The VCA is a tractable way of studying configurationally disordered systems; traditionally, the potentials which represent atoms of two or more elements are averaged into a composite atomic potential. We have overcome significant shortcomings of the standard VCA by developing a potential which yields averaged atomic properties. We perform the VCA on a ferroelectric oxide, determining the energy differences between the high-temperature rhombohedral, low-temperature rhombohedral and tetragonal phases of Pb(Zr_{1-x}Ti_x)O_3 at x=0.5 and comparing these results to superlattice calculations and experiment. We then use our new method to determine the preferred structural phase at x=0.4. We find that the low-temperature rhombohedral phase becomes the ground state at x=0.4, in agreement with experimental findings.Comment: 5 pages, no figure

Injury to muscle fibres after single stretches of passive and maximally stimulated muscles in mice.

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110091/1/tjp19954882459.pd

Orbits of Exceptional Groups, Duality and BPS States in String Theory

We give an invariant classification of orbits of the fundamental representations of exceptional groups $E_{7(7)}$ and $E_{6(6)}$ which classify BPS states in string and M theories toroidally compactified to d=4 and d=5. The exceptional Jordan algebra and the exceptional Freudenthal triple system and their cubic and quartic invariants play a major role in this classification. The cubic and quartic invariants correspond to the black hole entropy in d=5 and d=4, respectively. The classification of BPS states preserving different numbers of supersymmetries is in close parallel to the classification of the little groups and the orbits of timelike, lightlike and space-like vectors in Minkowski space. The orbits of BPS black holes in N=2 Maxwell-Einstein supergravity theories in d=4 and d=5 with symmetric space geometries are also classified including the exceptional N=2 theory that has $E_{7(-25)}$ and $E_{6(-26)}$ as its symmety in the respective dimensions.Comment: New references and two tables added, a new section on the orbits of N=2 Maxwell-Einstein supergravity theories in d=4 and d=5 included and some minor changes were made in other sections. 17 pages. Latex fil

Holographic Wilsonian flows and emergent fermions in extremal charged black holes

We study holographic Wilsonian RG in a general class of asymptotically AdS backgrounds with a U(1) gauge field. We consider free charged Dirac fermions in such a background, and integrate them up to an intermediate radial distance, yielding an equivalent low energy dual field theory. The new ingredient, compared to scalars, involves a `generalized' basis of coherent states which labels a particular half of the fermion components as coordinates or momenta, depending on the choice of quantization (standard or alternative). We apply this technology to explicitly compute RG flows of charged fermionic operators and their composites (double trace operators) in field theories dual to (a) pure AdS and (b) extremal charged black hole geometries. The flow diagrams and fixed points are determined explicitly. In the case of the extremal black hole, the RG flows connect two fixed points at the UV AdS boundary to two fixed points at the IR AdS_2 region. The double trace flow is shown, both numerically and analytically, to develop a pole singularity in the AdS_2 region at low frequency and near the Fermi momentum, which can be traced to the appearance of massless fermion modes on the low energy cut-off surface. The low energy field theory action we derive exactly agrees with the semi-holographic action proposed by Faulkner and Polchinski in arXiv:1001.5049 [hep-th]. In terms of field theory, the holographic version of Wilsonian RG leads to a quantum theory with random sources. In the extremal black hole background the random sources become `light' in the AdS_2 region near the Fermi surface and emerge as new dynamical degrees of freedom.Comment: 37 pages (including 8 pages of appendix), 10 figures and 2 table

Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells

Background: Breast cancer is the major cause of cancer-related mortality in women. It is thought that quiescent stem-like cells within solid tumors are responsible for cancer maintenance, progression and eventual metastasis. We recently reported that the chemokine receptor CCR7, a multi-functional regulator of breast cancer, maintains the stem-like cell population. Methods: This study used a combination of molecular and cellular assays on primary mammary tumor cells from the MMTV-PyMT transgenic mouse with or without CCR7 to examine the signaling crosstalk between CCR7 and Notch pathways. Results: We show for the first time that CCR7 functionally intersects with the Notch signaling pathway to regulate mammary cancer stem-like cells. In this cell subpopulation, CCR7 stimulation activated the Notch signaling pathway, and deletion of CCR7 significantly reduced the levels of activated cleaved Notch1. Moreover, blocking Notch activity prevented specific ligand-induced signaling of CCR7 and augmentation of mammary cancer stem-like cell function. Conclusion: Crosstalk between CCR7 and Notch1 promotes stemness in mammary cancer cells and may ultimately potentiate mammary tumor progression. Therefore, dual targeting of both the CCR7 receptor and Notch1 signaling axes may be a potential therapeutic avenue to specifically inhibit the functions of breast cancer stem cells.Sarah T. Boyle, Krystyna A. Gieniec, Carly E. Gregor, Jessica W. Faulkner, Shaun R. McColl and Marina Kochetkov

Holographic non-relativistic fermionic fixed point by the charged dilatonic black hole

Driven by the landscape of garden-variety condensed matter systems, we have investigated how the dual spectral function behaves at the non-relativistic as well as relativistic fermionic fixed point by considering the probe Dirac fermion in an extremal charged dilatonic black hole with zero entropy. Although the pattern for both of the appearance of flat band and emergence of Fermi surface is qualitatively similar to that given by the probe fermion in the extremal Reissner-Nordstrom AdS black hole, we find a distinctly different low energy behavior around the Fermi surface, which can be traced back to the different near horizon geometry. In particular, with the peculiar near horizon geometry of our extremal charged dilatonic black hole, the low energy behavior exhibits the universal linear dispersion relation and scaling property, where the former indicates that the dual liquid is a Fermi one while the latter implies that the dual liquid is not exactly of Landau Fermi type

Persistent Current of Free Electrons in the Plane

Predictions of Akkermans et al. are essentially changed when the Krein spectral displacement operator is regularized by means of zeta function. Instead of piecewise constant persistent current of free electrons on the plane one has a current which varies linearly with the flux and is antisymmetric with regard to all time preserving values of $\alpha$ including $1/2$. Different self-adjoint extensions of the problem and role of the resonance are discussed.Comment: (Comment on "Relation between Persistent Currents and the Scattering Matrix", Phys. Rev. Lett. {\bf 66}, 76 (1991)) plain latex, 4pp., IPNO/TH 94-2