433 research outputs found
Light charged Higgs boson production at the Large Hadron electron Collider
We study the production of a light charged Higgs boson at the future Large
Hadron electron Collider (LHeC), through the process
considering both decay channels and in the final state. We analyse these processes in the context of the
2-Higgs Doublet Model Type III (2HDM-III) and assess the LHeC sensitivity to
such signals against a variety of both reducible and irreducible
backgrounds. We confirm that prospects for detection in the 2HDM-III are
excellent assuming standard collider energy and luminosity conditions.Comment: 12 pages, 12 figures. Accepted in Physical Review
Confirmation of symmetrical distributions of clinical attachment loss and tooth loss in a homogeneous Mexican adult male population
Background/purpose
To ascertain whether or not clinical attachment loss and tooth loss are present with similar severity and prevalence across the two sides of the mouth in a homogeneous sample of urban male adults.
Materials and methods
A cross-sectional study was carried out on 161 policemen (a largely homogeneous group in terms of ethnic background, socioeconomic status, sex, occupation, and medical/dental insurance) in Campeche, Mexico. Periodontal examinations were undertaken using the Florida Probe System in a dental chair by one trained and standardized examiner (kappa ≥ 0.60) to determine clinical attachment loss and tooth loss. We examined six sites in all teeth present in the mouth (a maximum of 168 sites, no third molars). Because of correlated data between observations, McNemar (for tooth loss) and Wilcoxon (for attachment loss) signed-rank tests were used to compare right and left sites within the same patient.
Results
The mean age was 38.4 ± 11.0 years. The mean number of teeth present was 24.4 ± 4.6; the mean number of periodontal sites/person was 146.7 ± 27.8. All P values were ≥ 0.05 (except for attachment loss in the upper first premolars), suggesting that there were no statistically significant differences between the right and left sides for the frequency of presentation of these two conditions.
Conclusion
Tooth loss and attachment loss measurements largely resemble each other on both sides of the mouth
Analysis of the quark sector in the 2HDM-III with a four-zero Yukawa texture using the most recent data on the CKM matrix
In this letter we analyse, in the context of the general 2-Higgs Doublet
Model, the structure of the Yukawa matrices, , by assuming a four-zero texture ansatz for their definition. In this
framework, we obtain compact expressions for , which are reduced to the Cheng and Sher ansatz with the difference that
they are obtained naturally as a direct consequence of the invariants of the
fermion mass matrices. Furthermore, in order to avoid large flavour violating
effects coming from charged Higgs exchange, we consider the main flavour
constraints on the off-diagonal terms of Yukawa texture {{}} (). We perform a -fit
based on current experimental data on the quark masses and the
Cabibbo-Kobayashi-Maskawa mixing matrix . Hence, we obtain
the allowed ranges for the parameters at
1 for several values of . The results are in complete
agreement with the bounds obtained taking into account constraints on Flavour
Changing Neutral Currents reported in the literature.Comment: 12 pages, 1 figure. Version accepted in Phys. Lett.
Effects of physics beyond the standard model on the neutrino charge radius: an effective Lagrangian approach
In this work, we look for possible new physics effects on the electromagnetic
charge and anapole form factors, and , for a massless
Dirac neutrino, when these quantities are calculated in the context of an
effective electroweak Yang-Mills theory, which induces the most general
--invariant Lorentz tensor structure of nonrenormalizable type for the
vertex. It is found that in this context, besides the standard model
contribution, the additional contribution to and
( and , respectively) are gauge independent
and finite functions of after adopting a renormalization scheme. These
form factors, and , get contribution at
the one loop level only from the proper neutrino electromagnetic vertex.
Besides, the relation
(,
) is still fulfilled and
hence the relation (, )is gotten, just as in the SM. Using the experimental
constraint on the anomalous vertex, a value for the additional
contribution to the charge radius of |^{O_W}| \lsim 10^{-34}
cm^2 is obtained, which is one order of magnitude lower than the SM value.Comment: 9 pages, 3 figure
Tratamiento con nicergolina de dos casos de disfunción cognitiva en perros geriátricos
Dos perros con signos de disfunción cognitiva fueron tratados con nicergolina. El objetivo era poder mejorar el aporte sanguíneo al cerebro y retrasar los efectos propios del síndrome. En ambos casos se observó una mejora ostensible de su conducta. La nicergolina puede se útil en el tratamiento sintomático del síndrome.
Orai2 Modulates Store-Operated Ca2+ Entry and Cell Cycle Progression in Breast Cancer Cells
Breast cancer is a heterogeneous disease from the histological and molecular expression
point of view, and this heterogeneity determines cancer aggressiveness. Store-operated Ca2+ entry
(SOCE), a major mechanism for Ca2+ entry in non-excitable cells, is significantly remodeled in cancer
cells and plays an important role in the development and support of different cancer hallmarks. The
store-operated CRAC (Ca2+ release-activated Ca2+) channels are predominantly comprised of Orai1
but the participation of Orai2 and Orai3 subunits has been reported to modulate the magnitude of
Ca2+ responses. Here we provide evidence for a heterogeneous expression of Orai2 among different
breast cancer cell lines. In the HER2 and triple negative breast cancer cell lines SKBR3 and BT20,
respectively, where the expression of Orai2 was greater, Orai2 modulates the magnitude of SOCE
and sustain Ca2+ oscillations in response to carbachol. Interestingly, in these cells Orai2 modulates
the activation of NFAT1 and NFAT4 in response to high and low agonist concentrations. Finally, we
have found that, in cells with high Orai2 expression, Orai2 knockdown leads to cell cycle arrest at the
G0-G1 phase and decreases apoptosis resistance upon cisplatin treatment. Altogether, these findings
indicate that, in breast cancer cells with a high Orai2 expression, Orai2 plays a relevant functional
role in agonist-evoked Ca2+ signals, cell proliferation and apoptosis resistance.Ministerio de Ciencia e Innovación: PID2019-104084GB-C21Ministerio de Ciencia e Innovación: PID2019-104084GB-C22Consejería de Educación y Empleo, Junta de Extremadura: IB20007Consejería de Educación y Empleo, Junta de Extremadura: GR18061Consejería de Educación y Empleo, Junta de Extremadura: PD16072Consejería de Educación y Empleo, Junta de Extremadura: GR2100
Yukawa txtures and charged Higgs boson phenomenology in the type-III two-Higgs-doublet model
We discuss the implications of assuming a four-zero Yukawa texture for the
properties of the charged Higgs boson within the context of the general 2-Higgs
Doublet Model of Type III. We begin by presenting a detailed analysis of the
charged Higgs boson couplings with heavy quarks and the resulting pattern for
its decays. The production of charged Higgs bosons is also sensitive to the
modifications of its couplings, so that we also evaluate the resulting effects
on the top decay as well as on `direct'
and `indirect' production. Significant scope
exists at the Large Hadron Collider for several production and decay
channels combined to enable one to distinguish between such a model and
alternative 2-Higgs doublet scenarios.Comment: 30 pages, 18 figure
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