Sintering temperature influence on grains function distribution by neural network application

Artificial neural networks application in science and techonology begun during 20th century. This biophysical and biomimetic phenomena is based on extensive research which have led to understanding how neural as a living organism nerve system basic element processes signals by a simple algorithm. The input signals are massively parallel processed, and the output presents the superposition of all parallel processed signals. Artificial neural networks which are based on these principles are useful for solving various problems as pattern recognition, clustering, functional optimization. This research analyzed thermophysical parameters at samples based on Murata powders and consolidated by sintering process. Among different physical properties we applied out neural network approach on grain sizes distribution as a function of sintering temperature, 7: (from 1190-1370 degrees C). In this paper, we continue to apply neural networks to prognose structural and thermophysical parameters. For consolidation sintering process is very important to prognose and design malty parameters but especially thermal like temperature, to avoid long and even wrong experiments which are wasting the time and materials and energy as well. By this artificial neural networks method we indeed provide the most efficient procedure in projecting the mentioned parameters and provide successful ceramics samples production. This is very helpful in prediction and designing the micro-structure parameters important for advance microelectronic further miniaturization development. This is a quite original novelty for real micro-structure projecting especially on the phenomena within the thin films coating around the grains what opens new prospective in advance fractal microelectronics

FOUR CASES OF APPENDICEAL NEUROMA MIMICKING ACUTE APPENDICITIS

Herein we report four cases of appendiceal neuroma found during a short (one month) monitoring period in patients with severe pain in the lower right abdominal quadrant that underwent appendectomies. Tissue samples were routinely processed to obtain histological sections that were stained with hematoxylin and eosin (H&E) and further with anti-S100 protein antibody. Characteristics of appendiceal neuroma were noted in these cases and they included the absence of mucosal and lymphoid tissue of the appendices, stroma with spindle-shaped cells that were positively stained with anti-S100 protein antibody. This clinical entity is important due to a possible misdiagnosis with acute appendicitis or exacerbation of inflammatory bowel disease and great attention should be paid during the clinical evaluation of similar symptoms.Key words: appendiceal neuroma, misdiagnosis, lumen obliteration, immunohistochemistry, S100 protei

Invariants for Second Type Almost Geodesic Mappings of Symmetric Affine Connection Space

This paper presents the results concerning a space of invariants for second type almost geodesic mappings. After discussing the general formulas of invariants for mappings of symmetric affine connection spaces, based on these formulas, invariants for second type almost geodesic mappings of symmetric affine connection spaces and Riemannian spaces are obtained, as well as their mutual connection. Also, one invariant of Thomas type and two invariants of Weyl type for almost geodesic mappings of the second type were attained

An epidemiological study on herbal product self-medication practice among psychotic outpatients from Serbia: A cross-sectional study

Utilization of herbal products (HPs) is a common practice in the traditional medicine of people from southeastern Serbia. In this study, we focused on the usage of HPs as a self-medication practice among patients diagnosed with a mental illness, by aiming to ascertain the usage prevalence, the identity of the main plant taxa utilized, their formulations and target symptoms. This was accomplished through a cross-sectional study of psychiatric outpatients, conducted in the Clinic for Mental Health Protection in Niš, and which included a questionnaire on HP utilization and a non-structured psychiatric interview. Typically, single, middle-aged males, with a secondary education degree, utilized Matricaria chamomilla and/or Melissa officinalis in a form of an infusion (tea) for relieving anxiety and psychotic symptoms. In some cases, adverse effects were noted when HPs were used in combination with prescribed psychotropic medications. Our and previous results urge a thorough evaluation of possible benefits and/or harmful interactions of HP with standard medication in the treatment of psychiatric patients

Evaluation of pathological parameters and morphometric data of desmoplastic lobular breast carcinoma

Background: Invasive lobular breast cancer (ILC) is the second most frequent form of breast cancer. While cancer cells are regularly investigated, tumor stroma represents a highly unexplored field. Aims: The aim of this study is to perform a detailed investigation of clinical, immunohistochemical, and morphometric characteristics of desmoplastic (D) and nondesmoplastic (ND) ILC. Materials and Methods: This study included twenty cases of ILC that were divided into two groups designated as D and ND groups. Medical histories and diagnosis data were obtained from the archives of the Center of Pathology, Clinical center Niš (Serbia). Morphometric analysis of hematoxylin and eosin stained slides was performed using ImageJ software, and the obtained data were further statistical processed. Results: Statistical analyses of the data revealed that no significant differences between D and ND groups when patient age, estrogen receptor (ER), and progesterone receptor (PR) expressions and morphometrical parameters (such as the distance between groups of cancer cells and nucleocytoplasmic ratio) were compared. However, D and ND groups statistically, significantly differed in the occurrence of axillary lymph node metastasis, and when the ER and PR data were included, in certain nuclear parameters (cell/nucleus area, perimeter, Feret′s diameter, and circularity). Conclusions: Desmoplastic stroma was observed more frequently in patients without axillary lymph node metastases, whereas the expression of ER and PR had no influence on its development. According to the measured morphometric parameters larger cells/nuclei belonged to ND group

<i>Pulicaria dysenterica</i> (L.) Bernh.—Rightfully Earned Name? Identification and Biological Activity of New 3-Methoxycuminyl Esters from <i>P. dysenterica</i> Essential Oil

Motivated by the ethnopharmacological use of Pulicaria dysenterica, in the present study, the antimicrobial potential of the extracted essential oil was investigated against a panel of eighteen microorganism strains. Additionally, anti-acetylcholinesterase and antispasmodic (isolated rat distal colon) activities, general acute toxicity (Artemia salina model), and immunomodulatory properties (cytotoxicity on isolated mouse macrophages) were studied. Detailed analyses of the essential oil led to the identification of 3-methoxycuminyl 2-methylbutanoate (a new natural product) and 3-methoxycuminyl 3-methylbutanoate (a rare natural product). The obtained esters and intermediates in the synthesis of the starting alcohol (3-methoxycuminol) were subjected to a battery of 1D- and 2D-NMR experiments. The synthesized esters were additionally characterized by GC–MS, IR, and UV–Vis. The synthesized compounds (ten in total) were biologically tested in the same way as the extracted P. dysenterica essential oil. The obtained low acute toxicity and promising antimicrobial potential suggest that the P. dysenterica essential oil might partially explain the ethnopharmacological application of P. dysenterica plant material for the treatment of gastrointestinal infections

Differences in Angular Photogrammetric Soft-Tissue Facial Characteristics among Parents and Their Offspring

Background and objectives: The objective of this study was to determine if the angular photogrammetric analysis of soft-tissue characteristics can determine similarities between parents and their offspring in the Serbian population. Materials and Methods: A total of 15 families (52 participants) met the participation criteria of this study and their facial profile images were analyzed using the ImageJ software. Subjects were divided into groups of mothers and fathers and four groups of children (divided according to their age and gender). In total, twelve angular measurements were made on the standardized digital images of the profiles of the participants and the obtained data were compared using one-way ANOVA. Results: The obtained results showed that there were statistically significant differences in the values of the nasal and cervicomental angles, as well as the angle of the total facial convexity, between the group of fathers, on one side, and groups of male/female children, on the other. Conclusions: This work represents the first photogrammetric analysis of facial soft-tissue characteristics of children and adults in the Serbian population. The data suggest that there are much more similarities between the facial soft-tissue angles of fathers and their male offspring. Furthermore, mothers tend to have statistically insignificant differences in angle sizes, compared to both male and female offspring

High amount of lecithin facilitates oral delivery of a poorly soluble pyrazoloquinolinone ligand formulated in lipid nanoparticles: Physicochemical, structural and pharmacokinetic performances

Preclinical development of deuterated pyrazoloquinolinone ligands, promising drug candidates for various neuropsychiatric disorders, was hindered by unusually low solubility in water and oils. DK-I-60-3 (7-methoxy-d3-2-(4-methoxy-d3-phenyl)-2,5-dihydro-3Hpyrazolo[4,3-c]quinolin-3-one) is one of such pyrazoloquinolinones, and we recently reported about increased oral bioavailability of its nanocrystal formulation (NC). Lipid nanoparticles (LNP) with a high concentration of lecithin, which enhances loading capacity of the lipid matrix, may give rise to further improvement. After preformulation studies by differential scanning calorimetry and polarized light microscopy, LNP were prepared by the hot high pressure homogenization, and characterized in terms of particle size, morphology, and encapsulation efficacy. The layered structure visible on atomic force micrographs was confirmed by nuclear magnetic resonance. Obtained formulations were desirably stable, with small particle size (99 %). Lecithin was partially fluid and most probably located in the outer shell of the particle, together with DK-I-60-3. While the hydrophobic part of polysorbate 80 was completely immobilized, its hydrophilic part was free in the aqueous phase. In oral neuropharmacokinetic study in rats, an around 1.5-fold increase of area under the curve with LNP compared to NC was noticed both in brain and plasma. In bioavailability study, F value of LNP (34.7 ± 12.4 %) was 1.4-fold higher than of NC (24.5 ± 7.8 %); however, this difference did not reach statistical significance. Therefore, employment of LNP platform in preclinical formulation of DK-I-60-3 imparted an incremental improvement of its physicochemical as well as pharmacokinetic behavior