Mechanism and kinetics of aging in Inconel 718

Age hardening in Inconel 718 is investigated using Brinell hardness measurements. Formation of a precipitate causes an increase in hardness

Towards real-time classification of astronomical transients

Exploration of time domain is now a vibrant area of research in astronomy, driven by the advent of digital synoptic sky surveys. While panoramic surveys can detect variable or transient events, typically some follow-up observations are needed; for short-lived phenomena, a rapid response is essential. Ability to automatically classify and prioritize transient events for follow-up studies becomes critical as the data rates increase. We have been developing such methods using the data streams from the Palomar-Quest survey, the Catalina Sky Survey and others, using the VOEventNet framework. The goal is to automatically classify transient events, using the new measurements, combined with archival data (previous and multi-wavelength measurements), and contextual information (e.g., Galactic or ecliptic latitude, presence of a possible host galaxy nearby, etc.); and to iterate them dynamically as the follow-up data come in (e.g., light curves or colors). We have been investigating Bayesian methodologies for classification, as well as discriminated follow-up to optimize the use of available resources, including Naive Bayesian approach, and the non-parametric Gaussian process regression. We will also be deploying variants of the traditional machine learning techniques such as Neural Nets and Support Vector Machines on datasets of reliably classified transients as they build up

Recent results from the canfranc dark matter search with germanium detectors

Two germanium detectors are currently operating in the Canfranc Underground Laboratory at 2450 m.w.e looking for WIMP dark matter. One is a 2 kg 76Ge IGEX detector (RG-2) which has an energy threshold of 4 keV and a low-energy background rate of about 0.3 c/keV/kg/day. The other is a small (234 g) natural abundance Ge detector (COSME), of low energy threshold (2.5 keV) and an energy resolution of 0.4 keV at 10 keV which is looking for WIMPs and for solar axions. The analysis of 73 kg-days of data taken by COSME in a search for solar axions via their photon Primakoff conversion and Bragg scattering in the Ge crystal yields a 95% C.L. limit for the axion-photon coupling g < 2.8 10^-9 GeV^-1. These data, analyzed for WIMP searches provide an exclusion plot for WIMP-nucleon spin-independent interaction which improves previous plots in the low mass region. On the other hand, the exclusion plot derived from the 60 kg-days of data from the RG-2 IGEX detector improves the exclusion limits derived from other ionization (non thermal) germanium detector experiments in the region of WIMP masses from 30 to 100 GeV recently singled out by the reported DAMA annual modulation effect.Comment: 6 pages, talk given at IDM2000, York, September 200

ESTRO IORT Task Force/ACROP recommendations for intraoperative radiation therapy in borderline-resected pancreatic cancer

Radiation therapy (RT) is a valuable component of multimodal treatment for localized pancreatic cancer. Intraoperative radiation therapy (IORT) is a very precise RT modality to intensify the irradiation effect for cancer involving upper abdominal structures and organs, generally delivered with electrons (IOERT). Unresectable, borderline and resectable disease categories benefit from dose-escalated chemoradiation strategies in the context of active systemic therapy and potential radical surgery. Prolonged preoperative treatment may act as a filter for selecting patients with occult resistant metastatic disease. Encouraging survival rates have been documented in patients treated with preoperative chemoradiation followed by radical surgery and IOERT (>20 months median survival, >35% survival at 3 years). Intensive preoperative treatment, including induction chemotherapy followed by chemoradiation and an IOERT boost, appears to prolong long-term survival within the subset of patients who remain relapse-free for>2 years (>30 months median survival; >40% survival at 3 years). Improvement of local control through higher RT doses has an impact on the survival of patients with a lower tendency towards disease spread. IOERT is a well-accepted approach in the clinical scenario (maturity and reproducibility of results), and extremely accurate in terms of dose-deposition characteristics and normal tissue sparing. The technique can be adapted to systemic therapy and surgical progress. International guidelines (National Comprehensive Cancer Network or NCCN guidelines) currently recommend use of IOERT in cases of close surgical margins and residual disease. We hereby report the ESTRO/ACROP recommendations for performing IOERT in borderline-resectable pancreatic cancer

Elucidating cannabinoids’ effects on Ewing’s sarcoma tumor vasculature

To elucidate the mechanism by which AJA affects Ewing’s Sarcoma cellular pathways, we conducted an angiogenic array to observe AJA’s effects on fifty-five different angiogenic proteins. The angiogenic array showed potential upregulation of TIMP-1, an angiogenic inhibitor, but similar results have yet to be replicated in subsequent ELISA’s. Solid tumors commonly have high vascular densities and increased interstitial fluid pressures (IFP), which reduce the efficacy of treatments by inhibiting the absorption of therapeutic drugs. To determine the effects of AJA and CBD on IFP, and thus on vasculature in vivo, we measured IFP levels in mouse xenograft ES tumors. AJA and CBD both produced significant decreases in IFP within thirty minutes of injection, affirming their potential as legitimate cancer treatments

Physical Electronics

Contains reports on three research projects