Relationships between Brewer-Dobson circulation, double tropopauses, ozone and stratospheric water vapour

Statistical relationships between the variability of the area covered by double tropopause events (DTs), the strength of the tropical upwelling, the total column ozone and of the lower stratospheric water vapour are analyzed. The QBO and ENSO signals in the double tropopause and tropical upwelling as well as their influence on the statistical relationships are also presented. The analysis is based on both reanalysed data (ERA-Interim) and satellite data. Significant anticorrelations were found between the area covered by DTs and the total column ozone in the midlatitudes of the Northern Hemisphere. This relationship is confirmed by a large positive correlation between the areas covered by ozone laminae and double tropopause events as found in the HIRDLS satellite dataset. Significant anticorrelations were also found between the global area of double tropopause events and the near global (50◦S–50◦N) water vapour in the lower stratosphere. The correlations of DT variables with total column ozone and ozone laminae are both consistent with the poleward displacement of tropical air with lower ozone mixing ratio and with tropospheric intrusions of tropical tropospheric air into the lower extratropical stratosphere. The association of DTs with the poleward displacements of the tropical air is also consistent with a strong positive correlation between the area covered by DTs and the wave activity in the lower most stratosphere, between the first and second lapse rate tropopauses, as found in the ERA-Interim reanalysis. Finally, a significant anticorrelation was found between the tropical upwelling and the near global lower stratospheric water vapour. Moreover, the step like decrease in the lower stratospheric water vapour after 2001 is mirrored by a step like increase in the tropical upwelling.publishe

The double tropopause and its dynamical relationship to the tropopause inversion layer in storm track regions

Using High Resolution Dynamic Limb Sounder observations and ERA-Interim reanalysis this study demonstrates that the warm conveyor belt (WCB) is a mechanism responsible for the relationship between the double tropopause (DT) and the tropopause inversion layer (TIL), a relationship recently suggested in the literature based on idealized model simulations of baroclinic disturbances. Using these data sets, spatial and temporal characteristics of the DT-TIL relationship are examined over a 3 year period, 2005–2008. In the extratropics, results from satellite data show that as the TIL increases in strength, so does the frequency of the DT, regardless of season or hemisphere. The inverse relationship is found in the tropics. Using only DT profiles, zonal composites of wind, relative vorticity, and temperature from reanalysis data show that as the TIL increases in strength, the upper tropospheric circulation switches from cyclonic to anticyclonic, and the upward vertical motion increases. This result suggests the WCB as a mechanism since it is on the anticyclonic side of the jet and is characterized by the movement of tropical air poleward and upward from the surface. To verify this relationship, the vertical and horizontal development of a synoptic-scale baroclinic system is analyzed over a 4 day period. Results show the equatorward extension of the polar tropopause, and thus the formation of the DT, due to the strengthening of the TIL in the region of vertical motion associated with the WCB. Moreover, this result suggests that air movement within the DT could originate from high latitudes when associated with a baroclinic disturbance

Mania-like behavior induced by disruption of CLOCK

Circadian rhythms and the genes that make up the molecular clock have long been implicated in bipolar disorder. Genetic evidence in bipolar patients suggests that the central transcriptional activator of molecular rhythms, CLOCK, may be particularly important. However, the exact role of this gene in the development of this disorder remains unclear. Here we show that mice carrying a mutation in the Clock gene display an overall behavioral profile that is strikingly similar to human mania, including hyperactivity, decreased sleep, lowered depression-like behavior, lower anxiety, and an increase in the reward value for cocaine, sucrose, and medial forebrain bundle stimulation. Chronic administration of the mood stabilizer lithium returns many of these behavioral responses to wild-type levels. In addition, the Clock mutant mice have an increase in dopaminergic activity in the ventral tegmental area, and their behavioral abnormalities are rescued by expressing a functional CLOCK protein via viral-mediated gene transfer specifically in the ventral tegmental area. These findings establish the Clock mutant mice as a previously unrecognized model of human mania and reveal an important role for CLOCK in the dopaminergic system in regulating behavior and mood