Sur la mise en évidence de la tuberculose par le BCG-TEST chez les bovins tuberculeux rendus anergiques par injections répétées de tuberculine

Paraf Alain, Asso J. Sur la mise en évidence de la tuberculose par le BCG-TEST chez les bovins tuberculeux rendus anergiques par injections répétées et tuberculine. In: Bulletin de l'Académie Vétérinaire de France tome 111 n°4, 1958. pp. 183-188

Phénomènes de Reilly-Selye chez le Porc

Verge Jean, Goret Pierre, Paraf Alain. Phénomènes de Reilly-Selye chez le Porc. In: Bulletin de l'Académie Vétérinaire de France tome 109 n°1, 1956. pp. 27-32

Mammite à « Cryptococcus neoformans »

Ségretain G., Verge Jean, Drieux Henri, Mariat F., Paraf Alain, Labie C., Théron B. Mammite à «Cryptococcus neoformans». In: Bulletin de l'Académie Vétérinaire de France tome 109 n°1, 1956. pp. 33-41

Extra-Intestinal Manifestations of Familial Adenomatous Polyposis

Familial adenomatous polyposis (FAP) is an autosomal dominantly inherited disorder, which results from a germ line mutation in the APC (adenomatous polyposis coli) gene. FAP is characterized by the formation of hundreds to thousands of colorectal adenomatous polyps. Although the development of colorectal cancer stands out as the most prevalent complication, FAP is a multisystem disorder of growth. This means, it is comparable to other diseases such as the MEN syndromes, Von Hippel-Lindau disease and neurofibromatosis. However, the incidence of many of its clinical features is much lower. Therefore, a specialized multidisciplinary approach to optimize health care—common for other disorders—is not usually taken for FAP patients. Thus, clinicians that care for and counsel members of high-risk families should have familiarity with all the extra-intestinal manifestations of this syndrome. FAP-related complications, for which medical attention is essential, are not rare and their estimated lifetime risk presumably exceeds 30%. Affected individuals can develop thyroid and pancreatic cancer, hepatoblastomas, CNS tumors (especially medulloblastomas), and various benign tumors such as adrenal adenomas, osteomas, desmoid tumors and dental abnormalities. Due to improved longevity, as a result of better prevention of colorectal cancer, the risk of these clinical problems will further increase

Hyper-IgG4 disease: report and characterisation of a new disease

BACKGROUND: We highlight a chronic inflammatory disease we call 'hyper-IgG4 disease', which has many synonyms depending on the organ involved, the country of origin and the year of the report. It is characterized histologically by a lymphoplasmacytic inflammation with IgG4-positive cells and exuberant fibrosis, which leaves dense fibrosis on resolution. A typical example is idiopathic retroperitoneal fibrosis, but the initial report in 2001 was of sclerosing pancreatitis. METHODS: We report an index case with fever and severe systemic disease. We have also reviewed the histology of 11 further patients with idiopathic retroperitoneal fibrosis for evidence of IgG4-expressing plasma cells, and examined a wide range of other inflammatory conditions and fibrotic diseases as organ-specific controls. We have reviewed the published literature for disease associations with idiopathic, systemic fibrosing conditions and the synonyms: pseudotumour, myofibroblastic tumour, plasma cell granuloma, systemic fibrosis, xanthofibrogranulomatosis, and multifocal fibrosclerosis. RESULTS: Histology from all 12 patients showed, to varying degrees, fibrosis, intense inflammatory cell infiltration with lymphocytes, plasma cells, scattered neutrophils, and sometimes eosinophilic aggregates, with venulitis and obliterative arteritis. The majority of lymphocytes were T cells that expressed CD8 and CD4, with scattered B-cell-rich small lymphoid follicles. In all cases, there was a significant increase in IgG4-positive plasma cells compared with controls. In two cases, biopsies before and after steroid treatment were available, and only scattered plasma cells were seen after treatment, none of them expressing IgG4. Review of the literature shows that although pathology commonly appears confined to one organ, patients can have systemic symptoms and fever. In the active period, there is an acute phase response with a high serum concentration of IgG, and during this phase, there is a rapid clinical response to glucocorticoid steroid treatment. CONCLUSION: We believe that hyper-IgG4 disease is an important condition to recognise, as the diagnosis can be readily verified and the outcome with treatment is very good

Radiographie à l'aide d'un générateur pulsé de rayons X. Filtrage équilibré pour la mesure de largeur de dose à l'aide d'une diode PIN

La radiographie-éclair est une technique d'observation des phénomènes rapides en milieux opaques ou éclairants mettant en oeuvre des photons X pulsés. La durée d'émission est de quelques dizaines de ns et l'énergie des photons atteint plusieurs centaines de keV. Un effet de flou inhérent à cette technique, qui dépend en particulier de la dimension de la source d'émission et de la durée d'émission, se produit sur l'image formée. On emploie une diode PIN (Silicium) pour mesurer la largeur de dose. La sensibilité du silicium favorisant nettement les X mous, on a mis au point un filtre adapté dont l'atténuation uniformise en fonction de l'énergie la sensibilité d'ensemble. Ainsi, la mesure reflète mieux l'ensemble du spectre émis.Flash radiography enables studying fast events in opaque or lighting media, thanks to pulsed X rays. Emission time is about a few tenth of ns and X rays energy can reach several hundred of keV. Blurring on the image is an intrinsic phenomenon of flash radiography. This blurring depends mainely on the emission source size and on the emission time. We are using a PIN diode (Silicium) in order to measure the emission time. As silicium sensitivity is much higher for soft X rays, we develop a suited filter which attenuation tends to make the overall sensitivity almost flat with respect to X rays energy. Measurement this way is much more closed to the whole energy spectrum emitte