Low-dose alum application trialled as a management tool for internal nutrient loads in Lake Okaro, New Zealand

Aluminium sulfate (alum) was applied to Lake Okaro, a eutrophic New Zealand lake with recurrent cyanobacterial blooms, to evaluate its suitability for reducing trophic status and bloom frequency. The dose yielded 0.6 g aluminium m–3 in the epilimnion. Before dosing, pH exceeded 8 in epilimnetic waters but was optimal for flocculation (6–8) below 4 m depth. After dosing, there was no significant change in water clarity, hypolimnetic pH decreased to 5.5, and soluble aluminium exceeded recommended guidelines for protection of freshwater organisms. Epilimnetic phosphate concentrations decreased from 40 to 5 mg m–3 and total nitrogen (TN):total phosphorus (TP) mass ratios increased from 7:1 to 37:1. The dominant phytoplankton species changed from Anabaena spp. before dosing, to Ceratium hirudinella , then Staurastrum sp. after dosing. Detection of effectiveness of dosing may have been limited by sampling duration and design, as well as the low alum dose. The decrease in hypolimnetic pH and epilimnetic TP, and increase in Al3+ and chlorophyll a, are attributed to the low alkalinity lake water and coincidence of alum dosing with a cyanobacterial bloom and high pH

Monopoles in CP(N-1) model via the state-operator correspondence

One of the earliest proposed phase transitions beyond the Landau-Ginzburg-Wilson paradigm is the quantum critical point separating an antiferromagnet and a valence-bond-solid on a square lattice. The low energy description of this transition is believed to be given by the 2+1 dimensional CP(1) model -- a theory of bosonic spinons coupled to an abelian gauge field. Monopole defects of the gauge field play a prominent role in the physics of this phase transition. In the present paper, we use the state-operator correspondence of conformal field theory in conjunction with the 1/N expansion to study monopole operators at the critical fixed point of the CP(N-1) model. This elegant method reproduces the result for monopole scaling dimension obtained through a direct calculation by Murthy and Sachdev. The technical simplicity of our approach makes it the method of choice when dealing with monopole operators in a conformal field theory.Comment: 14 pages, 1 figur

Evidence for massive bulk Dirac Fermions in Pb1−x_{1-x}Snx_xSe from Nernst and thermopower experiments

The lead chalcogenides (Pb,Sn)Te and (Pb,Sn)Se are the first examples of topological crystalline insulators (TCI) predicted \cite{Fu,Hsieh} (and confirmed \cite{Hasan,Story,Takahashi}) to display topological surface Dirac states (SDS) that are protected by mirror symmetry. A starting premise \cite{Hsieh} is that the SDS arise from bulk states describable as massive Dirac states \cite{Wallis,Svane}, but this assumption is untested. Here we show that the thermoelectric response of the bulk states display features specific to the Dirac spectrum. We show that, in the quantum limit, the lowest Landau Level (LL) is singly spin-degenerate, whereas higher levels are doubly degenerate. The abrupt change in spin degeneracy leads to a large step-decrease in the thermopower $S_{xx}$. In the lowest LL, $S_{xx}$ displays a striking linear increase vs. magnetic field. In addition, the Nernst signal undergoes an anomalous sign change when the bulk gap inverts at 180 K.Comment: 16 pages, 8 figure

Structure Functions in Deep Inelastic Lepton-Nucleon Scattering

Latest results on structure functions, as available at the Lepton-Photon Symposium 1999, are presented. This report focusses on three experimental areas: new structure function measurements, in particular from HERA at low x and high Q2; results on light and heavy flavour densities; determinations of the gluon distribution and of alpha_s. As the talk was delivered at a historic moment and place, a few remarks were added recalling the exciting past and looking into the promising future of deep inelastic scattering.Comment: 27 pages, latex, 15 figures, Talk at Lepton-Photon Symposium, Stanford, August 199

Innate immune response to intramammary infection with Serratia marcescens and Streptococcus uberis

Streptococcus uberis and Serratia marcescens are Gram-positive and Gram-negative bacteria, respectively, that induce clinical mastitis. Once initial host barrier systems have been breached by these pathogens, the innate immune system provides the next level of defense against these infectious agents. The innate immune response is characterized by the induction of pro-inflammatory cytokines, as well as increases in other accessory proteins that facilitate host recognition and elimination of the pathogens. The objective of the current study was to characterize the innate immune response during clinical mastitis elicited by these two important, yet less well-studied, Gram-positive and Gram-negative organisms. The pro-inflammatory cytokine response and changes in the levels of the innate immune accessory recognition proteins, soluble CD14 (sCD14) and lipopolysaccharide (LPS)-binding protein (LBP), were studied. Decreased milk output, induction of a febrile response, and increased acute phase synthesis of LBP were all characteristic of the systemic response to intramammary infection with either organism. Infection with either bacteria similarly resulted in increased milk levels of IL-1$\beta$, IL-8, IL-10, IL-12, IFN-$\gamma$, TNF-$\alpha$, sCD14, LBP, and the complement component, C5a. However, the duration of and/or maximal changes in the increased levels of these inflammatory markers were significantly different for several of the inflammatory parameters assayed. In particular, S. uberis infection was characterized by the sustained elevation of higher milk levels of IL-1$\beta$, IL-10, IL-12, IFN-$\gamma$, and C5a, relative to S. marcescens infection. Together, these data demonstrate the variability of the innate immune response to two distinct mastitis pathogens

Population parameter estimates for performance and reproductive traits in Polish Large White nucleus herds

Performance test records from on-farm tests of young Polish Large White boars and reproductive records of Polish Large White sows from 94 nucleus farms during 1978 to 1987 were used to estimate population parameters for the measured traits. The number of boar performance records after editing was 114,347 from 3,932 sues, 21,543 dams, 44,493 litters and 1,075 herd-year-seasons. Reproductive performance records of sows involved 41,080 litters from 2,348 sires, 18,683 dams and 1,520 herd-year-seasons. Both data sets were analyzed by using restricted maximum-likelihood programs. The model used for the pedormance records included fixed herd-year-seasons, random sires, dams and error effects, and covariances for the year of birth of sire and year of birth of dam. The model used for the reproduction data set was the same as the performance data with parity as an additional fiied effect. Estimated heritabilities were .27, .29, .26, .07, .06, .06 for average daily gain standardized to 180 d (ADG), backfat thickness standardized to 110 kg BW (BF), days to 110 kg (DAYS), litter size at birth born alive (NBA), litter size at 21 d (N21) and litter weight at 21 d (W21). respectively. Estimated common environmental effects for the same traits were .09, .lo, .09, .06, .07 and .OS, respectively. Genetic correlations were .68 (NBA and W21) and .80 (N21 and W21). The respective phenotypic correlations were .23, -.99, -.20, .88, .75, .86. These population parameters for Polish Large White pigs are similar to those for breeds in other countries

Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging

Optimising response to tyrosine kinase inhibitors in cancer remains an extensive field of research. Intravital imaging is an emerging tool, which can be used in drug discovery to facilitate and fine-tune maximum drug response in live tumors. A greater understanding of intratumoural delivery and pharmacodynamics of a drug can be obtained by imaging drug target-specific fluorescence resonance energy transfer (FRET) biosensors in real time. Here, we outline our recent work using a Src-FRET biosensor as a readout of Src activity to gauge optimal tyrosine kinase inhibition in response to dasatinib treatment regimens in vivo. By simultaneously monitoring both the inhibition of Src using FRET imaging, and the modulation of the surrounding extracellular matrix using second harmonic generation (SHG) imaging, we were able to show enhanced drug penetrance and delivery to live pancreatic tumors. We discuss the implications of this dual intravital imaging approach in the context of altered tumor-stromal interactions, while summarising how this approach could be applied to assess other combination strategies or tyrosine kinase inhibitors in a preclinical setting

Coherent states and the classical-quantum limit considered from the point of view of entanglement

Three paradigms commonly used in classical, pre-quantum physics to describe particles (that is: the material point, the test-particle and the diluted particle (droplet model)) can be identified as limit-cases of a quantum regime in which pairs of particles interact without getting entangled with each other. This entanglement-free regime also provides a simplified model of what is called in the decoherence approach "islands of classicality", that is, preferred bases that would be selected through evolution by a Darwinist mechanism that aims at optimising information. We show how, under very general conditions, coherent states are natural candidates for classical pointer states. This occurs essentially because, when a (supposedly bosonic) system coherently exchanges only one quantum at a time with the (supposedly bosonic) environment, coherent states of the system do not get entangled with the environment, due to the bosonic symmetry.Comment: This is the definitive version of a paper entitled The classical-quantum limit considered from the point of view of entanglement: a survey (author T. Durt). The older version has been replaced by the definitive on