762 research outputs found
Interfacial Studies in Semiconductor Heterostructures by X-Ray Diffraction Techniques
X-ray radiation is a non-destructive probe well suited to assess structural perfection of semiconductor material. Three techniques are used to study the interfacial roughness, period fluctuations and annealing-induced interdiffusion in various superlattice structures. Reflectivity of long period Si/Si1-xGex multiple quantum wells reveals an asymmetry oriented along the direction of miscut in the interface roughness with the Si1-xGex to Si interfaces being about twice as rough (0.5 versus 0.3 nm) as the Si to Si1-xGex interfaces. For Si-Si0.65Ge0.35 multiple quantum wells, diffuse scattering is minimal for a growth temperature of 550°C and increases substantially at very low (250°C) or high (750°C) growth temperatures. In (SimGen)p short period superlattices, the X-ray reflectivity data are consistent with interfacial mixing over about two monolayers and thickness fluctuations of about 5% vertically in the structures. For superlattices grown on vicinal surfaces, the roughness spectrum is correlated with the surface miscut orientation. Double-crystal X-ray diffraction using symmetrical and asymmetrical reflections has been used to study epitaxial lattice distortion and strain relaxation in InGaAs/GaAs heterostructures grown on (100) on-orientation and 2° off (100) GaAs surfaces. It is shown that thick InGaAs films retain an appreciable fraction of their initial strain and that their crystal lattice is triclinically distorted. The magnitude of the deformation is larger when growth is carried out on a vicinal surface
Strong subadditivity and the covariant holographic entanglement entropy formula
Headrick and Takayanagi showed that the Ryu-Takayanagi holographic
entanglement entropy formula generally obeys the strong subadditivity (SSA)
inequality, a fundamental property of entropy. However, the Ryu-Takayanagi
formula only applies when the bulk spacetime is static. It is not known whether
the covariant generalization proposed by Hubeny, Rangamani, and Takayanagi
(HRT) also obeys SSA. We investigate this question in three-dimensional
AdS-Vaidya spacetimes, finding that SSA is obeyed as long as the bulk spacetime
satisfies the null energy condition. This provides strong support for the
validity of the HRT formula.Comment: 38 page
Unique Transcriptional Profile of Sustained Ligand-Activated Preconditioning in Pre- and Post-Ischemic Myocardium
BACKGROUND: Opioidergic SLP (sustained ligand-activated preconditioning) induced by 3–5 days of opioid receptor (OR) agonism induces persistent protection against ischemia-reperfusion (I-R) injury in young and aged hearts, and is mechanistically distinct from conventional preconditioning responses. We thus applied unbiased gene-array interrogation to identify molecular effects of SLP in pre- and post-ischemic myocardium. METHODOLOGY/PRINCIPAL FINDINGS: Male C57Bl/6 mice were implanted with 75 mg morphine or placebo pellets for 5 days. Resultant SLP did not modify cardiac function, and markedly reduced dysfunction and injury in perfused hearts subjected to 25 min ischemia/45 min reperfusion. Microarray analysis identified 14 up- and 86 down-regulated genes in normoxic hearts from SLP mice (≥1.3-fold change, FDR≤5%). Induced genes encoded sarcomeric/contractile proteins (Myh7, Mybpc3,Myom2,Des), natriuretic peptides (Nppa,Nppb) and stress-signaling elements (Csda,Ptgds). Highly repressed genes primarily encoded chemokines (Ccl2,Ccl4,Ccl7,Ccl9,Ccl13,Ccl3l3,Cxcl3), cytokines (Il1b,Il6,Tnf) and other proteins involved in inflammation/immunity (C3,Cd74,Cd83, Cd86,Hla-dbq1,Hla-drb1,Saa1,Selp,Serpina3), together with endoplasmic stress proteins (known: Dnajb1,Herpud1,Socs3; putative: Il6, Gadd45g,Rcan1) and transcriptional controllers (Egr2,Egr3, Fos,Hmox1,Nfkbid). Biological themes modified thus related to inflammation/immunity, together with cellular/cardiovascular movement and development. SLP also modified the transcriptional response to I-R (46 genes uniquely altered post-ischemia), which may influence later infarction/remodeling. This included up-regulated determinants of cellular resistance to oxidant (Mgst3,Gstm1,Gstm2) and other forms of stress (Xirp1,Ankrd1,Clu), and repression of stress-response genes (Hspa1a,Hspd1,Hsp90aa,Hsph1,Serpinh1) and Txnip. CONCLUSIONS: Protection via SLP is associated with transcriptional repression of inflammation/immunity, up-regulation of sarcomeric elements and natriuretic peptides, and modulation of cell stress, growth and development, while conventional protective molecules are unaltered
Proximity-to-goal as a constraint on patterns of behaviour in attacker-defender dyads in team games
Abstract The aim of this study was to determine whether spatiotemporal interactions between footballers and the ball in 1 vs. 1 sub-phases are influenced by their proximity to the goal area. Twelve participants (age 15.3 +/- 0.5 years) performed as attackers and defenders in 1 vs. 1 dyads across three field positions: (a) attacking the goal, (b) in midfield, and (c) advancing away from the goal area. In each position, the dribbler was required to move beyond an immediate defender with the ball towards the opposition goal. Interactions of attacker-defender dyads were filmed with player and ball displacement trajectories digitized using manual tracking software. One-way repeated measures analysis of variance was used to examine differences in mean defender-to-ball distance after this value had stabilized. Maximum attacker-to-ball distance was also compared as a function of proximity-to-goal. Significant differences were observed for defender-to-ball distance between locations (a) and (c) at the moment when the defender-to-ball distance had stabilized (a: 1.69 +/- 0.64 m; c: 1.15 +/- 0.59 m; P < 0.05). Findings indicate that proximity-to-goal influenced the performance of players, particularly when attacking or advancing away from goal areas, providing implications for training design in football. In this study, the task constraints of football revealed subtly different player interactions than observed in previous studies of dyadic systems in basketball and rugby union
5′-Nucleotidase activity and adenosine formation in stimulated, hypoxic and underperfused rat heart
Influence of Annealing on the Interface Structure and Strain Relief in Si/Ge Heterostructures on (100) Si
Research work on the general problem of the nature and thermal stability of the Si/Ge semiconductor interface is reviewed. We report on our recent studies of the interface structure in [(Si)m(Ge)n]p superlattices and (Ge)n layers buried in Si as revealed by Raman scattering, extended X-ray absorption fine structure, and X-ray techniques. Strain relaxation and interdiffusion in the superlattices caused by annealing have been investigated, and it is found that considerable strain-enhanced intermixing together with partial relaxation of Ge-Ge bonds occurs even for very short anneal times at 700°C. Further annealing leads to diffusion at a much slower rate and to the eventual formation of an alloy layer. The Ge-Ge bond lengths in as-grown samples are that expected for a fully strained Ge layer. Similar studies of the (Ge)n layers reveal that two-dimensional pseudomorphic growth proceeds up to n = 5, probably mediated by a Si-Ge interface interdiffusion over one or two monolayers of approximately 20%. A n = 12 layer gave evidence of strain relaxation by the introduction of dislocations and clustering. Interdiffusion proceeds rapidly on annealing at 750°C
A numerical approach to finding general stationary vacuum black holes
The Harmonic Einstein equation is the vacuum Einstein equation supplemented
by a gauge fixing term which we take to be that of DeTurck. For static black
holes analytically continued to Riemannian manifolds without boundary at the
horizon this equation has previously been shown to be elliptic, and Ricci flow
and Newton's method provide good numerical algorithms to solve it. Here we
extend these techniques to the arbitrary cohomogeneity stationary case which
must be treated in Lorentzian signature. For stationary spacetimes with
globally timelike Killing vector the Harmonic Einstein equation is elliptic. In
the presence of horizons and ergo-regions it is less obviously so. Motivated by
the Rigidity theorem we study a class of stationary black hole spacetimes,
considered previously by Harmark, general enough to include the asymptotically
flat case in higher dimensions. We argue the Harmonic Einstein equation
consistently truncates to this class of spacetimes giving an elliptic problem.
The Killing horizons and axes of rotational symmetry are boundaries for this
problem and we determine boundary conditions there. As a simple example we
numerically construct 4D rotating black holes in a cavity using Anderson's
boundary conditions. We demonstrate both Newton's method and Ricci flow to find
these Lorentzian solutions.Comment: 43 pages, 7 figure
Ricci flow and black holes
Gradient flow in a potential energy (or Euclidean action) landscape provides
a natural set of paths connecting different saddle points. We apply this method
to General Relativity, where gradient flow is Ricci flow, and focus on the
example of 4-dimensional Euclidean gravity with boundary S^1 x S^2,
representing the canonical ensemble for gravity in a box. At high temperature
the action has three saddle points: hot flat space and a large and small black
hole. Adding a time direction, these also give static 5-dimensional
Kaluza-Klein solutions, whose potential energy equals the 4-dimensional action.
The small black hole has a Gross-Perry-Yaffe-type negative mode, and is
therefore unstable under Ricci flow. We numerically simulate the two flows
seeded by this mode, finding that they lead to the large black hole and to hot
flat space respectively, in the latter case via a topology-changing
singularity. In the context of string theory these flows are world-sheet
renormalization group trajectories. We also use them to construct a novel free
energy diagram for the canonical ensemble.Comment: 31 pages, 14 color figures. v2: Discussion of the metric on the space
of metrics corrected and expanded, references adde
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