514 research outputs found
Dementiediagnostiek bij oudere migranten op de geheugenpolikliniek: obstakels en oplossingen
De komende tien jaar verdubbelt het aantal niet-westerse allochtone ouderen. Door specifieke risicofactoren (zoals
hypertensie en diabetes) zal het aantal oudere migranten met dementie waarschijnlijk toenemen. Geheugenpoliklinieken zijn
onvoldoende voorbereid op deze nieuwe patiëntenstroom, omdat zorgprofessionals onvoldoende kennis hebben van de
obstakels die bij interculturele dementiediagnostiek een rol spelen. Zij dienen rekening te houden met taalbarrière,
cultuurbarrière, het lage opleidingsniveau en analfabetisme van een aanzienlijk aantal patiënten, maar ook met onbekendheid
met dementie, schaamte en bijzondere zorgverwachtingen van de patiënten en hun familie. Er worden aanbevelingen gedaan
voor het verbeteren van communicatie, (neuropsychologische) testdiagnostiek en zorgadviezen in de klinische praktijk
Identification of a protein encoded in the EB-viral open reading frame BMRF2
Using monospecific rabbit sera against a peptide derived from a potential antigenic region of the Epstein-Barr viral amino acid sequence encoded in the open reading frame BMRF2 we could identify a protein-complex of 53/55 kDa in chemically induced B95-8, P3HR1 and Raji cell lines. This protein could be shown to be membrane-associated, as predicted by previous computer analysis of the secondary structure and hydrophilicity pattern, and may be a member of EBV-induced membrane proteins in lytically infected cells
A dynamical model for correlated two-pion-exchange in the pion-nucleon interaction
A microscopic model for the process is presented in the
meson exchange framework, which in the pseudophysical region agrees with
available quasiempirical information. The scalar () and vector ()
piece of correlated two--pion exchange in the pion--nucleon interaction is then
derived via dispersion integrals over the unitarity cut. Inherent ambiguities
in the method and implications for the description of pion--nucleon scattering
data are discussed.Comment: 20 pages, 11 postscript figure
Low Energy Pion-Hyperon Interaction
We study the low energy pion-hyperon interaction considering effective
non-linear chiral invariant Lagrangians including pions, rho mesons, hyperons
and corresponding resonances. Then we calculate the S- and P-wave phase-shifts,
total cross sections, angular distributions and polarizations for the momentum
in the center-of-mass frame up to k=400 MeV. With these results we discuss the
CP violation in the csi-> pi-lambda and omega-> pi-csi weak decays.Comment: 10 pages, 10 figure
Towards an understanding of isospin violation in pion-nucleon scattering
We investigate isospin breaking in low-energy pion-nucleon scattering in the
framework of chiral perturbation theory. This work extends the systematic
analysis of [1] to the energy range above threshold. Various relations, which
identically vanish in the limit of isospin symmetry, are used to quantify
isospin breaking effects. We study the energy dependence of the S- and P-wave
projections of these ratios and find dramatic effects in the S-waves of those
two relations which are given in terms of isoscalar quantities only. This
effect drops rather quickly with growing center-of-mass energy.Comment: 12 pp, REVTeX, 8 figs, FZJ-IKP(TH)-2000-2
New Class of Monoclonal Antibodies against Severe Influenza: Prophylactic and Therapeutic Efficacy in Ferrets
Background: The urgent medical need for innovative approaches to control influenza is emphasized by the widespread resistance of circulating subtype H1N1 viruses to the leading antiviral drug oseltamivir, the pandemic threat posed by the occurrences of human infections with highly pathogenic avian H5N1 viruses, and indeed the evolving swine-origin H1N1 influenza pandemic. A recently discovered class of human monoclonal antibodies with the ability to neutralize a broad spectrum of influenza viruses (including H1, H2, H5, H6 and H9 subtypes) has the potential to prevent and treat influenza in humans. Here we report the latest efficacy data for a representative antibody of this novel class. Methodology/Principal Findings: We evaluated the prophylactic and therapeutic efficacy of the human monoclonal antibody CR6261 against lethal challenge with the highly pathogenic avian H5N1 virus in ferrets, the optimal model of human influenza infection. Survival rates, clinically relevant disease signs such as changes in body weight and temperature, virus replication in lungs and upper respiratory tract, as well as macro- and microscopic pathology were investigated. Prophylactic administration of 30 and 10 mg/kg CR6261 prior to viral challenge completely prevented mortality, weight loss and reduced the amount of infectious virus in the lungs by more than 99.9%, abolished shedding of virus in phar
\pi\pi, K\pi and \pi N potential scattering and a prediction of a narrow \sigma meson resonance
Low energy scattering and bound state properties of the \pi N, \pi\pi and
K\pi systems are studied as coupled channel problems using inversion potentials
of phase shift data. In a first step we apply the potential model to explain
recent measurements of pionic hydrogen shift and width. Secondly, predictions
of the model for pionium lifetime and shift confirm a well known and widely
used effective range expression. Thirdly, as extension of this confirmation, we
predict an unexpected medium effect of the pionium lifetime which shortens by
several orders of magnitude. The \sigma meson shows a narrow resonance
structure as a function of the medium modified mass with the implication of
being essentially energy independent. Similarly, we see this medium resonance
effect realized for the K\pi system. To support our findings we present also
results for the \rho meson and the \Delta(1232) resonance.Comment: 42 pages, 17 PS figures, REFTeX, epsfig.sty needed, submitted to
Phys. Re
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